Dynamical Behavior of Somatostatin-14 and Its Cyclic Analogues as Analyzed in Bulk and on Plasmonic Silver Nanoparticles

Hernández, Belén; Coïc, Yves-Marie; López-Tobar, Eduardo; Sánchez-Cortés, Santiago; Baron, Bruno; Pflüger, Fernando; Kruglik, Sergei G.; Cohen, R.; Ghomi, Mahmoud

doi:10.1016/bs.apcsb.2018.01.002

Cited by 10 publications

(14 citation statements)

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“…A decade later, using Ag colloids, the first SERS data of aromatic amino acids, as well as those from short peptides and soluble proteins, were reported. − Recently, AgNPs were used to compare the data from aromatic amino acids by traditional SERS (excitation at 532 nm) and surface-enhanced hyper-Raman scattering (SEHRS) (double-photon excitation at 1064 nm) . From all of the reported SERS investigations, it can be deduced that the adsorption on AgNPs does not notably affect aromatic wavenumbers. − In other words, aromatic amino acids do not enter in tight interaction with Ag surface. − This has been corroborated by the DFT calculations on Trp–Ag complexes, showing that the zwitterionic amino acid preferentially binds to silver via its terminal charged groups …”

Section: Resultsmentioning

confidence: 99%

Tryptophan Tight Binding to Gold Nanoparticles Induces Drastic Changes in Indole Ring Raman Markers

et al. 2018

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Experimental conditions favoring the tryptophan tight binding to the surface of citrate-reduced gold nanoparticles (Cit-AuNPs) were explored. For this, the adsorption of three molecular compounds, free amino acid (Trp), tripeptide NH2-Gly-Trp-Gly-CONH2, and lanreotide, a synthetic cyclic somatostatin analogue, on large-size (∼70 nm) Cit-AuNPs was analyzed. UV–visible absorption, transmission electron microscopy, and surface-enhanced Raman scattering (SERS) were jointly used in the present investigation. At low pH (∼3.5), when the repulsive electrostatic interactions between gold particles are sufficiently reduced, both peptides can induce strong NP aggregation, leading particularly to substantial changes in the characteristic tryptophan Raman markers, as well as to the appearance of strong SERS markers at 1228 and 1113 cm–1. In contrast, upon increasing the pH toward a neutral value, the mentioned Trp Raman markers tend to adopt a spectral shape comparable to that observed in solution (bulk). In free amino acids, the SERS effect could not be observed within a large pH interval, except at low pH upon increasing the ionic strength. The reported data would be of benefit for following the adsorption processes that should be further considered in preparing Au-peptide nanodevices for therapeutic applications.

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Section: Resultsmentioning

confidence: 99%

Tryptophan Tight Binding to Gold Nanoparticles Induces Drastic Changes in Indole Ring Raman Markers

et al. 2018

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“…The high affinity of HA for AgCT is unusual, as the AgNPs exhibit a negative zeta potential , produced by the large amount of CT and its oxidation products adsorbed on the interface, which may avoid to a large extent the adsorption of the negatively charged humic substances. This is what also occurs on AgHX, where a large amount of adsorbed chloride ions decorates the surface (Figure A).…”

Section: Results and Discussionmentioning

confidence: 99%

Stimulated Adsorption of Humic Acids on Capped Plasmonic Ag Nanoparticles Investigated by Surface-Enhanced Optical Techniques

et al. 2019

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The adsorption of humic substances on Ag nanoparticles (AgNPs) is of crucial environmental importance and determines the toxicity of these NPs and the structure of adsorbed organic matter. In this work, the adsorption of two standard soil and leonardite International Humic Substances Society humic acids was studied on AgNPs of different sizes, shapes (spherical and star-like), and interfacial chemical compositions. Surface-enhanced optical (Raman and fluorescence) spectroscopies were used to follow the specific chemical groups involved in this adsorption. By means of the latter optical techniques, information regarding the binding mechanism and the macromolecular aggregation can be deduced. The influence of the surface chemical composition induced by the different functionalizations of the interfaces of these NPs is highly important regarding the chemical interactions of these complex organic macromolecules. The surface functionalization with positively charged alkyl diamines led to a large increase in the adsorption as well as a strong structural rearrangement of the macromolecule once adsorbed onto the surface.

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“…Tryptophan was singled out as the only aromatic amino acid with the ability to produce a tight binding on gold surfaces [ 60 ]. Differently, using the same type of peptides, AgNPs displayed no strong interaction with aromatic residues but showed high affinity for lysine side chains [ 61 ]. Such a degree of specificity between peptides and inorganic surfaces recalls the level of affinity existing among biological entities (i.e., antigen-antibody interactions).…”

Section: Molecular Biomimetics and Biomineralizationmentioning

confidence: 99%

Toward the Specificity of Bare Nanomaterial Surfaces for Protein Corona Formation

Vianello

Cecconello

Magro

2021

IJMS

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Aiming at creating smart nanomaterials for biomedical applications, nanotechnology aspires to develop a new generation of nanomaterials with the ability to recognize different biological components in a complex environment. It is common opinion that nanomaterials must be coated with organic or inorganic layers as a mandatory prerequisite for applications in biological systems. Thus, it is the nanomaterial surface coating that predominantly controls the nanomaterial fate in the biological environment. In the last decades, interdisciplinary studies involving not only life sciences, but all branches of scientific research, provided hints for obtaining uncoated inorganic materials able to interact with biological systems with high complexity and selectivity. Herein, the fragmentary literature on the interactions between bare abiotic materials and biological components is reviewed. Moreover, the most relevant examples of selective binding and the conceptualization of the general principles behind recognition mechanisms were provided. Nanoparticle features, such as crystalline facets, density and distribution of surface chemical groups, and surface roughness and topography were encompassed for deepening the comprehension of the general concept of recognition patterns.

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Dynamical Behavior of Somatostatin-14 and Its Cyclic Analogues as Analyzed in Bulk and on Plasmonic Silver Nanoparticles

Cited by 10 publications

References 102 publications

Tryptophan Tight Binding to Gold Nanoparticles Induces Drastic Changes in Indole Ring Raman Markers

Tryptophan Tight Binding to Gold Nanoparticles Induces Drastic Changes in Indole Ring Raman Markers

Stimulated Adsorption of Humic Acids on Capped Plasmonic Ag Nanoparticles Investigated by Surface-Enhanced Optical Techniques

Toward the Specificity of Bare Nanomaterial Surfaces for Protein Corona Formation

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