Dynamic visuomotor synchronization: Quantification of predictive timing

Maruta, Jun; Heaton, Kristin J.; Kryskow, Elisabeth M.; Maule, Alexis L.; Ghajar, Jamshid

doi:10.3758/s13428-012-0248-3

Cited by 38 publications

(54 citation statements)

References 54 publications

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“…In the Wash. U. behavioral session, for each block, the eye analysis software analyzed eye movement traces from the eye with the smaller SD of radial error. This procedure minimized the influence of noise on the data and is justified because ocular dominance should have little influence on visual tracking performance 35,36 ; a detailed rationale is described by Maruta and colleagues. 36 …”

Section: Visual Tracking Tasksmentioning

confidence: 99%

Abnormal White Matter Blood-Oxygen-Level–Dependent Signals in Chronic Mild Traumatic Brain Injury

Astafiev

Shulman

Metcalf

et al. 2015

Journal of Neurotrauma

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Concussion, or mild traumatic brain injury (mTBI), can cause persistent behavioral symptoms and cognitive impairment, but it is unclear if this condition is associated with detectable structural or functional brain changes. At two sites, chronic mTBI human subjects with persistent post-concussive symptoms (three months to five years after injury) and age-and education-matched healthy human control subjects underwent extensive neuropsychological and visual tracking eye movement tests. At one site, patients and controls also performed the visual tracking tasks while blood-oxygen-leveldependent (BOLD) signals were measured with functional magnetic resonance imaging. Although neither neuropsychological nor visual tracking measures distinguished patients from controls at the level of individual subjects, abnormal BOLD signals were reliably detected in patients. The most consistent changes were localized in white matter regions: anterior internal capsule and superior longitudinal fasciculus. In contrast, BOLD signals were normal in cortical regions, such as the frontal eye field and intraparietal sulcus, that mediate oculomotor and attention functions necessary for visual tracking. The abnormal BOLD signals accurately differentiated chronic mTBI patients from healthy controls at the single-subject level, although they did not correlate with symptoms or neuropsychological performance. We conclude that subjects with persistent post-concussive symptoms can be identified years after their TBI using fMRI and an eye movement task despite showing normal structural MRI and DTI.

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Section: Visual Tracking Tasksmentioning

confidence: 99%

Abnormal White Matter Blood-Oxygen-Level–Dependent Signals in Chronic Mild Traumatic Brain Injury

Astafiev

Shulman

Metcalf

et al. 2015

Journal of Neurotrauma

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“…Eye-movements can be recorded easily and rapidly using video-oculography, and the results are reliable. 34 EYE-TRAC DVS indices are based on continuous monitoring because the test paradigm does not require discrete responses. The ease of the task reduces the potential for effort issues and the likelihood of malingering, which is a common problem when evaluating TBI patients but is hard to identify.…”

Section: Discussionmentioning

confidence: 99%

“…31,34 The larger the SDTE value, the less stable the tracking. We also report vertical smooth pursuit velocity gain (V gain, Figure 2B), the ratio between the smooth pursuit eye velocity and the target velocity in the vertical direction, as a broader index of DVS.…”

Section: Eye-tracmentioning

confidence: 98%

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EYE-TRAC: monitoring attention and utility for mTBI

et al. 2012

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Attention is a core function in cognition and also the most prevalent cognitive deficit in mild traumatic brain injury (mTBI). Predictive timing is an essential element of attention functioning because sensory processing and execution of goal-oriented behavior are facilitated by temporally accurate prediction. It is hypothesized that impaired synchronization between prediction and external events accounts for the attention deficit in mTBI. Other cognitive and somatic or affective symptoms associated with mTBI may be explained as secondary consequences of impaired predictive timing. Eye-Tracking Rapid Attention Computation (EYE-TRAC) is the quantification of predictive timing with indices of dynamic visuo-motor synchronization (DVS) between the gaze and the target during continuous predictive visual tracking. Such quantification allows for cognitive performance monitoring in comparison to the overall population as well as within individuals over time. We report preliminary results of normative data and data collected from subjects with a history of mTBI within 2 weeks of injury and post-concussive symptoms at the time of recruitment. A substantial proportion of mTBI subjects demonstrated DVS scores worse than 95% of normal subjects. In addition, longitudinal monitoring of acute mTBI subjects showed that initially abnormal DVS scores were followed by improvement toward the normal range. In summary, EYE-TRAC provides fast and objective indices of DVS that allow comparison of attention performance to a normative standard and monitoring of within-individual changes.

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“…Specific deficits in oculomotor functions can be classed as deficits in smooth pursuit eye movements (SPEM), saccades and fixation-related behaviors. When performing circular smooth pursuittracking tasks, mTBI-related deficits in SPEM include decreased target prediction, increased eye position error, increased variability of eye position error [32,33], higher range inaccuracy in visual tracking as measured by variability of gaze position error relative to the target [31,34], smaller primary saccades, larger saccadic position errors, smaller saccadic amplitudes, slower predicted peak velocities, slower peak accelerations and abnormal pursuit velocities [35]. mTBI-related deficits in saccadic eye movements include significantly larger number of saccades but with significantly less precisely controlled end points [35][36][37].…”

Section: Oculomotor and Pupillometric Functionsmentioning

confidence: 99%

Feasibility of using normobaric hypoxic stress in mTBI research

et al. 2017

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Studies of mild traumatic brain injury (mTBI) recovery generally assess patients in unstressed conditions that permit compensation for impairments through increased effort expenditure. This possibility may explain why a subgroup of individuals report persistent mTBI symptoms yet perform normally on objective assessment. Accordingly, the development and utilization of stress paradigms may be effective for enhancing the sensitivity of mTBI assessment. Previous studies, discussed here, indirectly but plausibly support the use of normobaric hypoxia as a stressor in uncovering latent mTBI symptoms due to the overlapping symptomatology induced by both normobaric hypoxia and mTBI. Limited studies by our group and others further support this plausibility through proof-of-concept demonstrations that hypoxia reversibly induces disproportionately severe impairments of oculomotor, pupillometric, cognitive and autonomic function in mTBI individuals.

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Dynamic visuomotor synchronization: Quantification of predictive timing

Cited by 38 publications

References 54 publications

Abnormal White Matter Blood-Oxygen-Level–Dependent Signals in Chronic Mild Traumatic Brain Injury

Abnormal White Matter Blood-Oxygen-Level–Dependent Signals in Chronic Mild Traumatic Brain Injury

EYE-TRAC: monitoring attention and utility for mTBI

Feasibility of using normobaric hypoxic stress in mTBI research

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