Dynamic TurboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate: correlation with histopathologic results.

Jager, Gerrit J.; Ruijter, Emiel; Kaa, C.A. van de; Rosette, Jean J. de la; Oosterhof, G.O.N.; Thornbury, John R.; Ruijs, Sjef H. J.; Barentsz, Jelle O.

doi:10.1148/radiology.203.3.9169683

Cited by 219 publications

(128 citation statements)

References 24 publications

(25 reference statements)

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…Currently, there are no validated biomarkers that can predict tumors that are most likely to become castrate resistant and functional imaging techniques have the potential to noninvasively investigate the in vivo response of prostate tumors to therapy. Dynamic contrast-enhanced (DCE) MRI is a technique that can generate parameters thought to describe the microenvironment of both tumor and normal tissue, reflecting perfusion and capillary permeability (5,6). Diffusion-weighted imaging (DWI) displays information on the random motion of water molecules at the cellular level, along with cellular density and the integrity of the cell membranes and is thus sensitive to different tumor microenvironments.…”

mentioning

confidence: 99%

DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study

Barrett

Gill

Kataoka

et al. 2011

Magnetic Resonance in Med

View full text Add to dashboard Cite

Androgen deprivation therapy (ADT) is a key primary treatment for advanced and metastatic prostate cancer and is an important neoadjuvant before radiotherapy. We evaluated 3.0 T dynamic contrast-enhanced MRI and diffusion-weighted (DW) MRI in monitoring ADT response. Twenty-three consecutive patients with prostate cancer treated by primary ADT were included. Imaging was performed at baseline and 3 months posttreatment with ADT. After 3 months therapy there was a significant reduction in all dynamic contrast-enhanced MRI parameters measured in tumor regions of interest (K trans , k ep , v p , IAUGC-90); P < 0.001. Areas of normal-appearing peripheral zone showed no significant change; P 5 0.285-0.879. Post-ADT, there was no significant change in apparent diffusion coefficient values in tumors, whilst apparent diffusion coefficient values significantly decreased in areas of normalappearing peripheral zone, from 1.786 3 10 23 mm 2 /s to 1.561 3 10 23 mm 2 /s; P 5 0.007. As expected the median ProstateSpecific Antigen (PSA) significantly reduced from 30 ng/mL to 1.5 ng/mL posttreatment, and median prostate volume dropped from 47.6 cm 3 to 24.9 cm 3 ; P < 0.001. These results suggest that dynamic contrast-enhanced MRI and diffusionweighted MRI offer different information but that both could prove useful adjuncts to the anatomical information provided by T2-weighted imaging. dynamic contrast-enhanced as a marker of angiogenesis may help demonstrate ADT resistance and diffusion-weighted imaging may be more accurate in determining presence of tumor cell death versus residual tumor. Magn Reson Med 67:778-785,

show abstract

mentioning

confidence: 99%

DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study

Barrett

Gill

Kataoka

et al. 2011

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…This technique is also useful for identifying equivocal capsular penetration to assess the involvement of the seminal vesicles (9), and can be used to monitor neoadjuvant hormonal therapy (13). There are, however, conflicting reports as to whether DCE-MRI correlates well with histological grades of prostate carcinoma (8,10,14).…”

mentioning

confidence: 99%

Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology

Kozłowski

Chang

Jones

et al. 2006

Magnetic Resonance Imaging

245

192

View full text Add to dashboard Cite

Purpose:To determine whether the combination of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI provides higher diagnostic sensitivity for prostate cancer than each technique alone. Materials and Methods:Fourteen patients with a clinical suspicion of prostate cancer underwent endorectal MRI on a 1.5T scanner prior to transrectal ultrasound (TRUS)-guided biopsies. The average values of the apparent diffusion coefficient (ADC, calculated from b-values of 0 and 600), K trans , v e , maximum gadolinium (Gd) concentration, onset time, mean gradient, and maximum enhancement were determined. Correlation with histology was based on biopsy (six patients) and prostatectomy specimen (eight patients) results. The Tukey-Kramer test was used for statistical analysis. Results:The average values of all MRI parameters, except v e and maximum Gd concentration, showed significant differences between tumor and normal prostate. The sensitivity and specificity values were respectively 54% (35-72%) and 100% (95-100%) for the ADC data, and 59% (39 -77%) and 74% (63-83%) for the DCE data. When both ADC and DCE results were combined, the sensitivity increased to 87% (68 -95%) and specificity decreased to 74% (62-83%). Conclusion:All but two DW-and DCE-MRI parameters showed significant differences between tumor and normal prostate. Combining both techniques provides better sensitivity, with a small decrease in specificity.

show abstract

“…[9][10][11][12][13] In this study, surface coil MRI, a more widely available imaging technique, was a reasonably accurate predictor of tumour stage in patients with adverse prognostic features for locally advanced disease. Thus, in centres without an endorectal coil or more advanced technologies, surface coil MRI seems to be a useful alternative preoperative investigation in select patients.…”

Section: Discussionmentioning

confidence: 85%

Diagnostic accuracy of surface coil magnetic resonance imaging at 1.5 T for local staging of elevated risk prostate cancer

Kim

Breau

Papadatos

et al. 2013

CUAJ

View full text Add to dashboard Cite

Introduction: Preoperative prostate cancer stage predicts prognosis and affects treatment decisions. The purpose of this study was to estimate the sensitivity and specificity of surface coil magnetic resonance imaging (MRI) for prostate cancer stage using surgical pathologic data as the reference standard. Methods: High-risk patients (≥cT3 or PSA ≥20 ng/mL or Gleason ≥8) and selected intermediate-risk patients (clinically bulky disease on exam or biopsy, cT2b/c, or Gleason 7 with ≥3 of 5 biopsy cores positive in a lobe) routinely received a pelvic MRI at our institution. The images of identified patients were reviewed by one radiologist who was blinded to clinical information. The radiologist reported presence or absence of tumour within each lobe of the prostate. Extraprostatic extension (EPE), seminal vesicle (SV) invasion and pelvic lymph node (PLN) metastasis were also reported. Radiological findings were compared with prostatectomy pathology reports. Results: During the study period, about 320 radical prostatectomies were performed. Of these, 32 had a preoperative surface coil pelvic MRI adequate for analysis. Pathologically, 53 of 64 (82.8%) prostate lobes contained tumour, 17 (26.6%) lobes had associated EPE, 12 (18.8%) had SV involvement and 7 (10.9%) sets of PLNs contained cancer. Magnetic resonance imaging sensitivity and specificity were, respectively, 94.3% and 81.8% for tumour location, 82.4% and 87.2% for EPE, 83.3% and 92.3% for SV invasion and 71.4% and 94.7% for PLN involvement. Interpretation: Surface coil MRI accurately stages many prostate cancer patients with elevated risk of extraprostatic disease. This mode of imaging may be reasonable at centres that do not have endorectal coil MRI. RésuméIntroduction : Le stade du cancer de la prostate avant l'opération permet d'établir le pronostic et influe sur les décisions en ce qui concerne le traitement. Notre étude avait pour objectif d'évaluer la sensibilité et la spécificité de l'imagerie par résonance magnétique avec bobine de surface dans l'établissement du stade du cancer de la prostate en utilisant les données pathologiques liées à la chirurgie comme données de référence. Méthodologie : Les patients à risque élevé (tumeur ≥cT3 ou taux d'APS ≥20 ng/mL ou score de Gleason ≥ 8) et certains patients à risque intermédiaire (maladie volumineuse sur le plan clinique lors de l'examen ou à la biopsie, tumeur cT2b/c, ou score de Gleason de 7 avec au moins 3 carottes biopsiques sur 5 prélevées dans le même lobe qui soient positives) subissent un examen par IRM de façon systématique à notre établissement. Les images des patients inclus dans l'étude ont été examinées par un radiologiste à qui les données cliniques n'avaient pas été divulguées (examen à l'insu). Le radiologiste signalait la présence ou l'absence de tumeur dans chaque lobe prostatique. On a aussi signalé des cas d'extension extraprostatique, d'envahissement des vésicules séminales et de métastases touchant les ganglions lymphatiques pelviens. Les observations radiologiques ont été ...

show abstract

Dynamic TurboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate: correlation with histopathologic results.

Abstract: Abbreviations: BPH = benign prostatic hyperplasia, FLASH = fast low-angle shot, SE « spin echo.

Cited by 219 publications

References 24 publications

DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study

DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study

Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology

Diagnostic accuracy of surface coil magnetic resonance imaging at 1.5 T for local staging of elevated risk prostate cancer

Contact Info

Product

Resources

About