Dynamic Tracking of Biological Processes Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes

Basu, Srestha; Hendler-Neumark, Adi; Bisker, Gili

doi:10.1021/acsami.4c10955

ACS Appl. Mater. Interfaces

2024

DOI: 10.1021/acsami.4c10955

|View full text |Cite

Dynamic Tracking of Biological Processes Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes

Srestha Basu,

Adi Hendler-Neumark,

Gili Bisker

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Ratiometric Normalization of Near-Infrared Fluorescence in Defect-Engineered Single-Walled Carbon Nanotubes for Cholesterol Detection

Basu,

Hendler-Neumark,

Bisker

2024

J. Phys. Chem. Lett.

View full text Add to dashboard Cite

Ratiometric probing of analytes presents a substantial advancement in molecular recognition, offering self-calibrating signals that enhance the measurement accuracy and reliability. We present a dual-emitting probe based on (6,5) chirality-enriched single-walled carbon nanotubes (SWCNTs) with oxygen defects for cholesterol (Chol) detection using ratiometric fluorescence readouts. The interaction with Chol induced significant intensity variations in the E 11 and E 11 * emission peaks of oxygen defect-induced SWCNTs, giving rise to ratiometric fluorescence changes. The sensitivity of these probes toward Chol in water and serum was 0.28 ± 0.01 and 0.72 ± 0.05 μM, respectively, which is comparable to that of common gold standards for cholesterol detection used in clinical samples. By utilizing ratiometric readouts, our approach enhanced selectivity over numerous competing analytes, including amino acids, sugars, cations, anions, proteins, steroid hormones, surfactants, and phospholipids. Mechanistic investigations revealed that Chol detection by defect-integrated SWCNTs was facilitated by Chol incorporation within micelles formed by sodium cholate, the surfactant dispersant used for the SWCNT suspension. Oxygen defects played a crucial role by directly interacting with Chol. This strategy employing defect-integrated dual-peak NIR-emitting SWCNTs as sensors for Chol in aqueous and serum environments not only enables background-free detection of biologically relevant analytes but also advances biosensing using SWCNTs through tailored surface functionalization and advanced read-out concepts.

show abstract

Ratiometric Normalization of Near-Infrared Fluorescence in Defect-Engineered Single-Walled Carbon Nanotubes for Cholesterol Detection

Basu,

Hendler-Neumark,

Bisker

2024

J. Phys. Chem. Lett.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Dynamic Tracking of Biological Processes Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes

Cited by 1 publication

References 125 publications

Ratiometric Normalization of Near-Infrared Fluorescence in Defect-Engineered Single-Walled Carbon Nanotubes for Cholesterol Detection

Ratiometric Normalization of Near-Infrared Fluorescence in Defect-Engineered Single-Walled Carbon Nanotubes for Cholesterol Detection

Contact Info

Product

Resources

About