Dynamic thiol/disulphide homeostasis and pathogenesis of Kawasaki disease

Abstract

Background Kawasaki disease (KD) is an acute, self‐limited, systemic vasculitis of unknown etiology. In the present study, we investigated whether there is a relationship between KD and dynamic thiol/disulphide homeostasis. Methods This case–control study involved KD patients and healthy controls. Plasma total, native and disulphide thiol and the disulphide/native, disulphide/total and native thiol/total thiol ratios of all patients and the control group were analyzed simultaneously. Results A total of 20 patients with KD (male/female, 12/8) and 25 age‐ and gender‐matched healthy controls (male/female, 12/13) were evaluated. Native, total thiol and native thiol/total thiol ratio were significantly lower in KD patients than in the control group (P < 0.001). In contrast, disulphide thiol, disulphide/native thiol and disulphide/total thiol ratios were significantly higher in KD patients than control subjects (P < 0.001). In KD patients with coronary artery lesion (CAL), the native thiol and total thiol were significantly lower than in KD patients without CAL. In KD patients with CAL, the ratios of disulphide/total thiol and disulphide/native thiol were significantly higher than in those without CAL (P = 0.02 and P = 0.02, respectively), whereas the ratio of native/total thiol was significantly lower (P = 0.02). Conclusion The KD patients had lower plasma thiol (native and total) and higher disulphide thiol than controls, indicating that dynamic thiol/disulphide homeostasis might be an important indicator of inflammation in KD. Alteration and shifting of thiol/disulphide homeostasis to the oxidized side are correlated with the pathogenesis of KD and CAL.

Thiol disulfide balance in children with vitamin B12 deficiency

“…Bu dengenin klinik uygulamadaki rolünün araştırıldığı bir derlemede 35 çalışma değerlendirilmiş ve tiyol/disülfit dengesinin vücuttaki koruyucu etkisi olduğu ve birçok hastalıkta tanısal belirteç olarak kullanılabileceği belirtilmiştir 8 . Pediatrik yaş grubunda ise tiyol/disülfit dengesinin polikistik over hastalığı 9 , akut tonsillofarenjit 10 , obezite 11 , atopik dermatit 12 , epilepsi 13 , hipotiroidi 14 , bazı metabolik hastalıklar 15 , hipertansiyon 16 , kafa travması 17 , juvenil idiopatik artrit 18 , febril nöbet 19 , akut böbrek hasarı 20 , nefrotik sendrom 21 , Kawasaki hastalığı 22 ve sepsis 23…”

Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker

“…In the contrary case, it may be said that reduction increases. It was projected that determining how much thiol-disulfide values change under which conditions would shed light on the pathogenesis of many diseases, and numerous studies have been carried out on this subject (6,7).…”