Dynamic thiol/disulfide homeostasis in patients with autoimmune subclinical hypothyroidism

Ateş, İhsan; Altay, Mustafa; Yılmaz, Fatma Meriç; Topçuoğlu, Canan; Neşeli̇oğlu, Salim; Erel, Özcan; Yılmaz, Nisbet

doi:10.3109/07435800.2016.1156124

Cited by 19 publications

(21 citation statements)

References 21 publications

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“…Thiol/disulfit homeostazı (TDH) anti-oksidan korunma, detoksifikasyon, hücre büyümesi ve aopopitozu gibi birçok hücresel aktivitede kritik role sahiptir (10,11) . Daha önceleri prediabet, otoimmün subklinik hipotiroidizm (Hashimoto tiroiditi), polikistik over sendromu, Kırım Kongo hemorajik ateşi, ani sensorinöral işitme kaybı, prematür ovariyan yetmezlik gibi birçak farklı hastalıkta TDH'nın etyopatogenetik rolü araştırılmıştır (12)(13)(14)(15) . Bu homeostazın immün etyopatogenezde çok önemli rol oynadığı ve TDH'ındaki dengesizliğin oksidatif stres ve doku inflamasyonu aracılığıyla hastalığı tetiklediği düşünülmektedir.…”

Section: Introductionunclassified

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Üstüner¹

2017

IKSST

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Section: Introductionunclassified

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Üstüner¹

2017

IKSST

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“…Previous studies reported increased OS in adult patients with SHT [11-13]; these studies either included only patients with autoimmune hypothyroidism [11-13] or the presence of autoimmune thyroiditis was not reported [20, 21]. Hashimoto thyroiditis is a chronic inflammatory autoimmune disease.…”

Section: Discussionmentioning

confidence: 99%

“…Abnormal thiol/disulphide homeostasis plays a pivotal role in the pathophysiology of many chronic inflammatory diseases [14-16]. Increased OS may be related to autoimmunity in patients with Hashimoto thyroiditis [11]. The objective of this study was to evaluate dynamic thiol/disulphide homeostasis in children and adolescents with non-autoimmune SHT.…”

Section: Introductionmentioning

confidence: 99%

“…Thiol/disulphide homeostasis is regarded as an indicator of OS [9, 10]. OS markers have been found to be increased in patients with autoimmune SHT [11-13]. …”

Section: Introductionmentioning

confidence: 99%

“…Hashimoto thyroiditis is a chronic inflammatory and autoimmune disease [11]. Abnormal thiol/disulphide homeostasis plays a pivotal role in the pathophysiology of many chronic inflammatory diseases [14-16].…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Thiol/Disulphide Homeostasis in Children and Adolescents with Non-Autoimmune Subclinical Hypothyroidism

et al. 2018

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Objective: To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism (SHT). Subjects and Methods: Thiol/disulphide homeosta sis, involving native thiol (SH), disulphide (SS), and total thiol (SS + SH), was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a thyroid-stimulating hormone (TSH) value of > 5 mIU/L, and in 40 sex- and age-matched healthy control subjects who were negative for thyroid autoantibodies and had normal TSH levels. Lipid profiles and urine iodine levels were also determined. Results: SH (466 ± 32.8 vs. 462 ± 32.1 μmol/L p = 0.59), SH + SS (508 ± 34.0 vs. 506 ± 32.7 μmol/L, p = 0.81), SS (21 ± 5.5 vs. 22 ± 5.8 μmol/L, p = 0.41), SS/SH (4.5 ± 1.2 vs. 4.8 ± 1.3%, p = 0.36), SS/SH + SS (4.1 ± 1.0 vs. 4.3 ± 1.1%, p = 0.36) and SH/SH + SS (91 ± 2.1 vs. 91 ± 2.1%, p = 0.31) levels were similar in children with SHT and control subjects (p > 0.05). There was no difference between total cholesterol, triglyceride, and low-density lipoprotein levels in SHT patients and controls. No difference was detected between the patients with or without iodine deficiency in the SHT group in terms of thiol/disulphide homeostasis parameters. Conclusion: The status of dynamic thiol/disulphide homeostasis did not change in children and adolescents with non-autoimmune SHT. Future studies are needed for the evaluation of oxidative stress in patients with long-standing non-autoimmune SHT.

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Changes in biomarkers of the redox status in whole blood and red blood cell lysates in canine hypothyroidism

González-Arostegui,

Muñoz-Prieto,

García-López

et al. 2024

Vet Res Commun

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Hypothyroidism is the most commonly diagnosed endocrine disease in dogs. The objective of this study was to evaluate the changes in the redox status in canine hypothyroidism using whole blood (WB) and red blood cell (RBCs) lysates. For this purpose, a panel of five antioxidants and five oxidants biomarkers was measured in WB and RBCs lysates of 30 dogs with hypothyroidism, 26 dogs with non-thyroidal illnesses and 15 healthy dogs. The antioxidants measured were cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), thiol and paraoxonase type-1 (PON-1). Oxidants measured include the total oxidant status (TOS), peroxide-activity (POX-Act), reactive oxygen-derived metabolites (d-ROMs), advanced oxidation protein products (AOPP) and thiobarbituric acid reactive substances (TBARS). WB showed a significant decrease of the antioxidants CUPRAC, TEAC and thiol, and also an increase in TBARS and a decrease in AOPP in dogs with hypothyroidism compared to healthy dogs. Meanwhile, RBCs lysates showed a significant increase in FRAP and PON-1 in dogs with hypothyroidism. The changes in the redox biomarkers in this study show that WB in canine hypothyroidism had a higher number of changes in biomarkers of the redox status than RBCs lysates, making it a promising sample type for the evaluation of the redox status in this disease. In addition, WB is easier and simpler to process than RBCs lysates and unlike serum, it does not have any hemolysis interference.

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Dynamic thiol/disulfide homeostasis in patients with autoimmune subclinical hypothyroidism

Cited by 19 publications

References 21 publications

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Dynamic Thiol/Disulphide Homeostasis in Children and Adolescents with Non-Autoimmune Subclinical Hypothyroidism

Changes in biomarkers of the redox status in whole blood and red blood cell lysates in canine hypothyroidism

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