Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism

Or, Koca Arzu; Dağdeviren, Murat; Akkan, Tolga; Ateş, İhsan; Neşeli̇oğlu, Salim; Erel, Özcan; Altay, Mustafa

doi:10.2478/jomb-2019-0036

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…We detected that native thiol, total thiol, disulphide values, and disulphide/native thiol, disulphide/total thiol ratios of HT patients were significantly higher, while native thiol/ total thiol ratio of these patients were significantly lower compared to controls. Similarly, in the study of Koca et al, (2019), the disulphide, disulphide/native thiol, disulphide/total thiol levels were found higher in a patient with hypoparathyroidism [31]. Mengen et al, (2020) reported high levels of thiol/ disulphide homeostasis and IMA levels in obesity [32].…”

Section: Discussionmentioning

confidence: 60%

Ischemia modified albumin and thiol/disulfide balance in patients with Hashimoto’s thyroiditis

Avci¹,

Karabulut²,

Avci³

et al. 2022

Ukr. Biochem. J.

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Hashimoto thyroiditis is a common cause of goiter and acquired hypothyroidism in individuals residing in areas of no iodine deficiency. The fact that the structure of serum albumin exhibits changes in ischemic conditions has paved the way for the discovery of a new serum cardiac ischemia marker, Ischemia Modified Albumin. The other one, thiol/disulphide homeostasis, plays an important part in antioxidative protection, detoxification, cell growth, and apoptosis. In this study, we aimed to investigate both the relationship between Thiol/Disulphide homeostasis and Ischemia Modified Albumin in patients diagnosed with Hashimoto's thyroiditis. A total of 70 Hashimoto's thyroiditis patients and 50 healthy ones were included in this study. Age, gender, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase (TPO), anti-thyroglobulin (TG) levels were recorded. Ischemia Modified Albumin and thiol-disulphid homeostasis parameters were measured through automated spectrophotometric methods. the ages of individuals included in the study ranged from 35 to 58 years. The native thiol/total thiol were found to be significantly lower in Hashimoto patients when compared to those enrolled in the control group (P < 0.05), whereas the Ischemia Modified Albumin, disulphide, native thiol, total thiol, disulphide/native thiol, and disulphide/total thiol were found to be significantly higher in Hashimoto patients when compared to those in the control (P < 0.05). Increased Ischemia Modified Albumin, native and total thiol, and disulphide levels are related to increased oxidative stress. Although Ischemia Modified Albumin and Thiol-disulphide defense are important oxidative indicators in Hashimoto's thyroiditis, many determinants are known to be involved in this process.

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Section: Discussionmentioning

confidence: 60%

Ischemia modified albumin and thiol/disulfide balance in patients with Hashimoto’s thyroiditis

Avci¹,

Karabulut²,

Avci³

et al. 2022

Ukr. Biochem. J.

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“…Currently, numerous markers can be employed to evaluate the level of oxidative stress in a biological system [ 11 , 12 ]. Recently, researchers have focused on thiol-disulfide homeostasis (TDH) as a new marker of oxidative stress [ 13 , 14 , 15 ]. Protein thiol groups are the main antioxidants in plasma [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Thiol-Disulfide Homeostasis in Skin Diseases

Georgescu

Mitran

et al. 2022

JCM

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Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). In 2014, Erel and Neselioglu developed a novel automated assay to measure thiol and disulfide levels. Subsequently, many researchers have used this simple, inexpensive and fast method for evaluating TDH in various disorders. We have reviewed the literature on the role of TDH in skin diseases. We identified 26 studies that evaluated TDH in inflammatory diseases (psoriasis, seborrheic dermatitis, atopic dermatitis, vitiligo, acne vulgaris and rosacea), allergic diseases (acute and chronic urticaria) and infectious diseases (warts, pityriasis rosea and tinea versicolor). The results are heterogeneous, but in most cases indicate changes in TDH that shifted toward disulfides or toward thiols, depending on the extent of oxidative damage.

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