Dynamic testing of prolactin and growth hormone secretion in patiens with neuroendocrine disorders

Müller, E. E.; Cavagnini, Francesco; Martínez-Campos, Abraham; Maraschini, C.; Giovannini, P.; Novelli, Antonello; Leo, V. De

doi:10.1530/acta.0.1070155

Cited by 16 publications

(4 citation statements)

References 13 publications

(14 reference statements)

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“…A severe reduc¬ tion in adrenal size and function within 2 years of MPA treatment was noted sooner than previously reported in dogs treated with MPA for 45 months (Frank et al 1979). The failure of TRH to in¬ crease GH in acromegalie dogs contrasts with the increased GH observed in the majority of acrome¬ galie humans injected with TRH (Müller et al 1984). …”

Section: Discussionmentioning

confidence: 95%

Growth hormone, insulin, glucose, cortisol, luteinizing hormone, and diabetes in beagle bitches treated with medroxyprogesterone acetate

McCann

Altszuler

Hampshire

et al. 1987

Acta Endocrinologica

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Adult beagle bitches (20 to 101 months old) received medroxyprogesterone acetate (MPA; 75 mg/ kg, im) or control vehicle at 3 month intervals. Changes in serum concentrations of GH, insulin and glucose were determined in 18 MPA-treated and 6 of 12 control bitches at 0, 2, 4, 8, 16 and 17\p=n-\24months of treatment (Exp. I). GH, LH and cortisol responsiveness to combined im injection of TRH (10 \g=m\g/kg), GnRH (10 \ g = m \ g / k g ) , and ACTH (5 \g=m\g/kg) was determined in 9 MPA-treated and 9 control bitches at 17 months of treatment (Exp. II). In Exp. I, serum concentrations of GH at month 2 (2.6 \ m=+-\ 0.3 \g=m\g/l ), 4 (3.0 \ m=+-\ 0.3 \g=m\g/l ), 8 (4.0 \m=+-\1.2 \g=m\g/l), 16 (8.5 \m=+-\1.7 \g=m\g/l ), and 17\p=n-\24 (21.2 \ m=+-\ 4.1 \g=m\g/l) of treatment were greater (P < 0.05) than pretreatment (1.4 \ m=+-\ 0.07 \g=m\g/l )and control (1.5 \ m=+-\ 0.1 \g=m\g/l ) levels. The increase in GH at 2 months preceded (N = 4) or coincided (N = 2) with the development of hyperinsulinaemia and insulin resistance in 6 of the 18 treated bitches, two of which became diabetic by 17 months of MPA treatment. GH (24.6 \m=+-\ 5. 0vs 11.4 \m=+-\ 2. 1 \g=m\g/l)and insulin (308 \m=+-\77 vs 119 \m=+-\9 pmol/l) concentrations were greater (P < 0.05) in older (49 \m=+-\4 months; N = 12) than in the younger (26 \ m=+-\2 months; N = 6) treated bitches at 17\p=n-\24months of MPA treatment. In Exp. II, pretreatment concentrations of GH were increased (9.8 \ m=+-\3.0 vs 1.4 \ m=+-\0.1 \g=m\g/l , P < 0.01), cortisol levels decreased (12 \m=+-\5 vs 72 \m=+-\ 10 nmol/l, P < 0.01) and LH concentrations (0.9 \ m=+-\0.2 \g=m\g/l ) unaffected in MPA-treated bitches. After injection of tropic hormones, GH was unchanged, whereas the rises in LH and cortisol levels were less (P < 0.01) in MPA-treated bitches than in control bitches. The results demonstrate that high doses of MPA increase GH concentrations within 2 months and that the GH overproduction and its diabetogenic-like effects were more pronounced in the older than in the younger treated bitches.

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Section: Discussionmentioning

confidence: 95%

Growth hormone, insulin, glucose, cortisol, luteinizing hormone, and diabetes in beagle bitches treated with medroxyprogesterone acetate

McCann

Altszuler

Hampshire

et al. 1987

Acta Endocrinologica

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“…Sex steroids are regarded as capable of stimulating GH secretion [4], The postpartum period is important for the induction of lactation. It follows pregnancy with its high levels of circulating steroids which continue to condition hypo thalamo-pituitary activity [5][6][7], The importance of high prolactin (Prl) levels during this period is well known. Increasing during pregnancy, plasma Prl levels reach a maximum before delivery [8,9], The best-known action of Prl in humans is the induction and maintenance of lac tation [10,11], Prl secretion is inhibited by dopamine (DA) release by T1DA system neurons.…”

Section: Introductionmentioning

confidence: 99%

Control of Growth Hormone Secretion during the Postpartum Period

Leo

Lanzetta²,

Donato³

et al. 1992

Gynecol Obstet Invest

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The postpartum period is characterized by high levels of circulating steroids which condition hypothalamo-pituitary activities. In pregnancy growth hormone (GH) levels are greatly increased and lack pulsatility. In order to investigate the behavior of GH during the postpartum period, the GH response to GH-releasing hormone stimulation (50 and 100 µg), to amphetamine, a dopamine receptor agonist, and to FK 33-824, an opiate receptor agonist, was investigated in women during the first 5 days after delivery. In all groups GH responses were significantly lower (p < 0.01) than in normal women studied during the early follicular phase. FK-33-824-induced GH release was similar in postpartum and control women. These results demonstrate reduced pituitary GH response to GH-releasing hormone and to amphetamine in women during the postpartum period, confirming the peculiarity of the hypothalamo-pituitary component.

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“…The same favorable prognostic value of a TRH positive response has been found in the prolactin secreting pituitary adenomas. 27 It is not possible from this study to determine if this "paradoxical" response to TRH is due to a liberation of GH stored in intracytoplasmic granules of tumor cells or is the result of increased synthesis of GH in those cells; however, since it was found that intracytoplasmic granules are more abundant in the cells of those TRH positive cases, it is possible that "paradoxical" TRH response results from the liberation of previously stored GH. In vitro studies in prolactin secreting pituitary adenomas in regard to PRL secretion, indicate that the positive response to TRH is probably due to an increased release of PRL from cell granules.…”

Section: Discussionmentioning

confidence: 79%

Differential Response to Aminergic Stimuli and Biological Behavior of Growth Hormone Secreting Pituitary Adenomas

Fanghänel

Larraza

Villalobos

et al. 1990

Can. j. neurol. sci.

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Growth hormone (GH) serum levels in response to the administration of aminergic drugs and thyroliberine (TRH) were determined in a group of 34 acromegalics. Administration of bromocriptine (10 mg single oral dose) was followed by a decrease in GH below 60% control values in 35% of the cases. Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%. Administration of cyproheptadine (24 mg/day for one month) to those cases not responding to bromocriptine or with increased GH after the administration of diazepam, decreased GH in 75%, while increased GH in 25% of the cases. TRH 200 (Xg single I.V. dose induced increase of 128% GH basal level in 65% of cases (TRH positive) which correlated with more benign clinical course, decreased GH levels in response to bromocriptine, increased PRL levels, PRL-GH mixed secreting adenomas in immunohistochemistry studies, presence of granulated cells in electron microscopy studies and normalization of GH in the majority of surgically treated cases. By contrast, TRH negative cells correlated with aggressive tumor growth, lack of response to bromocriptine, normal PRL levels, pure GH secreting adenomas by immunohistochemistry, poorly granulated cells and lack of response to surgical treatment. Results suggest that there is more than one type of acromegaly that might be distinguished by the aminergic control on GH secretion.

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Dynamic testing of prolactin and growth hormone secretion in patiens with neuroendocrine disorders

Cited by 16 publications

References 13 publications

Growth hormone, insulin, glucose, cortisol, luteinizing hormone, and diabetes in beagle bitches treated with medroxyprogesterone acetate

Growth hormone, insulin, glucose, cortisol, luteinizing hormone, and diabetes in beagle bitches treated with medroxyprogesterone acetate

Control of Growth Hormone Secretion during the Postpartum Period

Differential Response to Aminergic Stimuli and Biological Behavior of Growth Hormone Secreting Pituitary Adenomas

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