Dynamic structural controlment for the functionalization of polyelectrolyte multilayer films

Huang, Wei‐Pin; Hu, Jiaqi; Qian, Hong‐Lin; Ren, Keke; Ji, Jian

doi:10.1016/j.supmat.2022.100016

Cited by 2 publications

(2 citation statements)

References 147 publications

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“…Finally, in-film biomineralization is carried out to obtain the outermost microand nanoscopically featured CaP layer to enhance scaffold hydrophilicity and mimic the rough surface of the bone structures to promote bone formation. [19] The scaffold, denoted as CaP@P@PUF, integrated the porosity, piezoelectricity, and biochemical features of bone tissue and is attractive for bone formation.…”

Section: Introductionmentioning

confidence: 99%

Biomineralized Piezoelectrically Active Scaffolds for Inducing Osteogenic Differentiation

Zhang

et al. 2023

Chemistry A European J

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There is an endogenous electric field in living organisms, which plays a vital role in the development and regeneration of bone tissue. Therefore, self-powered piezoelectric material for bone repair has become hot research in recent years. However, the current piezoelectric materials for tissue regeneration still have the shortcomings of lack of biological activity and three-dimensional structure. Here, we proposed a three-dimensional polyurethane foam (PUF) scaffold coated with piezoelectric poly (vinylidene fluorideco-hexafluoropropylene) (PVDF-HFP) and modified by a calcium phosphate (CaP) mineralized coating. The preferred scaffold has an open circuit voltage and short circuit current output of 5 V and 200 nA. Combining the physical and chemical properties of the CaP coating, the piezoelectric signal of PVDF-HFP and the three-dimensional structure of PUF, the scaffold exhibits superior promotion of cell osteogenic differentiation and ectopic bone formation in vivo. The mechanism is attributed to an increase in intracellular Ca 2 + levels in response to chemical and piezoelectric stimulation with the material. This research not only paves the way for the application of piezoelectric scaffolds to stimulate osteoblasts differentiation in situ, but also lays the foundation for the clinical treatment of long-term osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Biomineralized Piezoelectrically Active Scaffolds for Inducing Osteogenic Differentiation

Zhang

et al. 2023

Chemistry A European J

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“…[12][13][14][15] These soft devices can arouse biophysical signals as well as serve as sensitive mechanical force reporters. [16] Importantly, the concept of piezoionic mechanoreceptors have been recently realized in artificial systems taking advantage of the differences in streaming speeds of sodium and chloride ions in a hydrogel matrix. Significant electric voltages over 10 mV have been realized.…”

Section: Introductionmentioning

confidence: 99%

Piezoionic High Performance Hydrogel Generator and Active Protein Absorber via Microscopic Porosity and Phase Blending

Lu,

Chen,

Zhang

et al. 2023

Advanced Materials

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Generating electricity in hydrogel is very important but remains difficult. Hydrogel with electricity generation capability is more capable in bio‐relevant tasks such as tissue engineering, artificial skin, or medical treatment, because electricity is indispensable in regulating physiological activities. Here, a porous and phase blending hydrogel structure for effective piezoionic electricity generation is developed. Dynamic electric field is generated taking advantage of the difference in streaming speeds of sodium and chloride in the material. Microscopic porosity and hydrophilic‐hydrophobic phase blending are the two key factors for prominent piezoionic performance. Voltages as high as 600 mV are first realized in hydrogels in response to medical ultrasound stimulation. The hydrogel structure is also subjective to effective substance exchange and can actively enrich proteins from surroundings under mechanical stimuli. Preliminary applications in neural stimulation, constructing complex spatial‐temporal chemical and electric field distribution patterns, mimetic tactile sensor, sample pretreatment in fast detection, and enzyme immobilization are demonstrated.

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Dynamic structural controlment for the functionalization of polyelectrolyte multilayer films

Cited by 2 publications

References 147 publications

Biomineralized Piezoelectrically Active Scaffolds for Inducing Osteogenic Differentiation

Biomineralized Piezoelectrically Active Scaffolds for Inducing Osteogenic Differentiation

Piezoionic High Performance Hydrogel Generator and Active Protein Absorber via Microscopic Porosity and Phase Blending

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