Dynamic Strength Training Improves Insulin Sensitivity without Altering Plasma Levels and Gene Expression of Adipokines in Subcutaneous Adipose Tissue in Obese Men

Klimčáková, Eva; Polàk, Jan; Moro, Cédric; Hejnova, J.; Majercik, M.; Viguerie, Nathalie; Berlan, Michel; Langin, Dominique; Štich, Vladimír

doi:10.1210/jc.2006-0382

Cited by 140 publications

(150 citation statements)

References 36 publications

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“…Moreover, a significant difference was observed in the plasma level of adiponectin in the experimental group between the pre-test and post-test stages. The increase in the plasma level of adiponectin as a result of 12 weeks of aquarobics exercises was most likely a preventive factor for diseases related to adiponectin (32,36). In this research, the increase in the level of adiponectin after adjusting to the aquarobics exercises was similar to the results of a number of previous studies.…”

Section: Discussionsupporting

confidence: 88%

“…These findings confirm those of previous studies that found improvement in insulin sensitivity after exercise training in obese and healthy individuals (20) Several mechanisms have been proposed to be responsible for the increases in insulin sensitivity after exercise training (29). These include increased post-receptor insulin signaling (30), increased glucose transporter protein and mRNA (31), increased activity of glycogen syntheses and hexokinase (15), increased muscle glucose delivery and changes in muscle composition (32). Restoring insulin sensitivity by circuit weight training might be mediated mainly by mechanisms other than adiponectin, for instance, by the AMP-activated protein kinase pathway (33).…”

Section: Discussionmentioning

confidence: 99%

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Beneficial Health Effect of Aquarobics (Role of Adiponectin on Women with Obesity)

Baitul

Susanto

Kushartanti

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Background the effects of exercise on adiponectin levels have been reported to be variable. Obesity is associated with adipose tissue inflammation and increased risk of infection. The prevalence of obesity increased in premenopausal women both in developed countries and developing countries, including Indonesia. The purpose of the study to investigate the effect of aquarobics exercise on adiponectin levels in women with obesity. Methods of the research, experimental randomized pretest-posttest control group design performed in twenty four women with obesity (Obese II BMI> 30kg/m2) aged 45-50 years, who were divided into 2 groups, aquarobic exercise group, twice days for 8 weeks (n=12), aquarobic intensity 75%HRmax, and control group (n=12). Percentage of body fat, BMI, adiponectin levels, blood glucose and lipids profile were measured before and after exercise. Data were analyzed using repeated measures and while Pearson's correlations were performed to identify possible relationship among the assessed variables. Results of the study, the percentage of body fat was higher in aquarobic exercises than control group (p<0.05). Decreased of BMI on the aquarobic exercises group compared to controls (p<0.05) and adiponectin levels in the aquarobic exercise group increase significantly (p<0.05). Conclusion: Aquarobic exercise is effective to decreased body weight and increase adiponectin levels.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Beneficial Health Effect of Aquarobics (Role of Adiponectin on Women with Obesity)

Baitul

Susanto

Kushartanti

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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“…Several studies have investigated the effect of exercise on adiponectin concentration in humans. Although some studies found that the concentration of circulating adiponectin increased after exercise (Lim et al, 2008;Kondo et al, 2006), in other studies, the concentration of circulating adiponectin was unchanged after exercise (Jürimäe et al, 2007;O'Leary et al, 2006;Klimcakova et al, 2006;Nassis et al, 2005;Hara et al, 2005). Likewise, some studies have reported that the concentration of circulating adiponectin in healthy and diabetic rodents increased after exercise (Zeng et al, 2007;Lee et al, 2011), whereas in other studies, the concentration of circulating adiponectin in healthy rodents was unchanged after exercise (Lee et al, 2011;Bhattacharya et al, 2005;Huang et al, 2007).…”

Section: Exercise Alters Adipokine Secretionmentioning

confidence: 98%

Exercise-induced adaptations to white and brown adipose tissue

Lehnig

Stanford

2018

Journal of Experimental Biology

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The beneficial effects of exercise on skeletal muscle and the cardiovascular system have long been known. Recent studies have focused on investigating the effects of exercise on adipose tissue and the effects that these exercise-induced adaptations have on overall metabolic health. Examination of exercise-induced adaptations in both white adipose tissue (WAT) and brown adipose tissue (BAT) has revealed marked differences in each tissue with exercise. In WAT, there are changes to both subcutaneous WAT (scWAT) and visceral WAT (vWAT), including decreased adipocyte size and lipid content, increased expression of metabolic genes, altered secretion of adipokines and increased mitochondrial activity. Adaptations specific to scWAT include lipidomic remodeling of phospholipids and, in rodents, the beiging of scWAT. The changes to BAT are less clear: studies evaluating the effect of exercise on the BAT of humans and rodents have revealed contradictory data, making this an important area of current investigation. In this Review, we discuss the exerciseinduced changes to WAT and BAT that have been reported by different studies and highlight the current questions in this field.

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“…Thereafter, needle biopsy (diameter of needle 12G) of SAT was carried out in the abdominal region (10 cm laterally from umbilicus) under local anesthesia (1% Xylocain) as previously described. 31 In subgroup 1, one part of SAT (approximately 0.5 g) was immediately frozen at À80 1C until subsequent gene expression analysis and the other part of SAT (approximately 2 g) was directly used for isolation of SVF cells. In subgroup 2, SAT was processed immediately to obtain SVF for flow cytometry.…”

Section: Dietary Intervention and Clinical Investigationmentioning

confidence: 99%

“…Total RNA extraction and reverse-transcription PCR were performed as previously described. 31 Before reverse transcription, genomic DNA was eliminated by DNase I (Invitrogen, Carlsbad, CA, USA). Real-time quantitative PCR was performed using an ABI PRISM 7000 Sequence Detection System (Applied Biosystems, Foster City, CA, USA).…”

Section: Quantification Of Macrophage Markers Expression By Quantitatmentioning

confidence: 99%

Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

et al. 2010

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Objective: Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. The aim of our study was to investigate the effect of long-term dietary intervention on ATM content in human adipose tissue. Design: We performed a multi-phase longitudinal study. Subjects and measurements: A total of 27 obese pre-menopausal women (age 39±2 years, body mass index 33.7±0.5 kg m -2 ) underwent a 6-month dietary intervention consisting of two periods: 4 weeks of very low-calorie diet (VLCD) followed by weight stabilization composed of 2 months of low-calorie diet and 3to 4 months of weight maintenance diet. At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. ATMs were determined by flow cytometry using combinations of cell surface markers. Selected cytokine and chemokine plasma levels were measured using enzyme-linked immunosorbent assay. In addition, in a subgroup of 16 subjects, gene expression profiling of macrophage markers in SAT was performed using real-time PCR. Results: Dietary intervention led to a significant decrease in body weight, plasma insulin and C-reactive protein levels. After VLCD, ATM content defined by CD45 þ /14 þ /206 þ did not change, whereas it decreased at the end of the intervention. This decrease was associated with a downregulation of macrophage marker mRNA levels (CD14, CD163, CD68 and LYVE-1 (lymphatic vessel endothelial hyaluronan receptor-1)) and plasma levels of monocyte-chemoattractant protein-1 (MCP-1) and CXCL5 (chemokine (C-X-C motif) ligand 5). During the whole dietary intervention, the proportion of two ATM subpopulations distinguished by the CD16 marker was not changed. Conclusion: A 6-month weight-reducing dietary intervention, but not VLCD, promotes a decrease in the number of the whole ATM population with no change in the relative distribution of ATM subsets.

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Dynamic Strength Training Improves Insulin Sensitivity without Altering Plasma Levels and Gene Expression of Adipokines in Subcutaneous Adipose Tissue in Obese Men

Cited by 140 publications

References 36 publications

Beneficial Health Effect of Aquarobics (Role of Adiponectin on Women with Obesity)

Beneficial Health Effect of Aquarobics (Role of Adiponectin on Women with Obesity)

Exercise-induced adaptations to white and brown adipose tissue

Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

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