Dynamic stereotactic radiosurgery in the palliative treatment of cerebral metastatic tumors

Abstract

From October 1988 to April 1990, 9 patients with metastatic brain disease (11 lesions) underwent stereotactic radiosurgery. All patients but two had recurrent metastatic disease after previous brain irradiation. The patients were treated with a single dose of 20 Gy, delivered to spherical target volumes ranging in diameters from 10 mm to 30 mm and prescribed to the 90% isodose surface. All tumors treated showed a favorable response to the treatment, with 4 patients achieving a complete radiological disappearance of the tumor. The majority of the patients experienced a rapid clinical improvement of their symptoms. No complications attributable to the radiosurgical treatment were seen. Stereotactic radiosurgery appears to be an effective and safe treatment for patients with recurrent metastatic brain disease.

MR Imaging Response of Brain Metastases after Gamma Knife Stereotactic Radiosurgery

“…The results of previous reports (13,14,(32)(33)(34)(35) have indicated that stereotactic radiosurgery is effective in treating brain metastases, regardless of their histology, including those that are resistant to conventional whole-brain radiation therapy, such as those that originate from melanoma and renal cell carcinoma.…”

Stereotactic Radiosurgery for Brain Metastases From Breast Cancer

“…It can be used in conjunction with, or as an alternative to, other treatment methods. [2][3][4][5][6][7][8] Radiosurgery is an appealing option for patients with brain metastases. The procedure requires only a single overnight stay and can even be performed on an outpatient basis.…”

“…Stereotactic radiosurgery is an alternative option that can be used either alone or in conjunction with other treatment methods. Although radiosurgery has been found to be an effective, noninvasive, and low-morbidity treatment for brain metastases in general, [2][3][4][5][6][7][8] no previous study has specifically examined the subgroup of patients with breast cancer. Despite the great numbers of patients with brain metastases from breast cancer, few reports document patient outcomes.…”

Stereotactic radiosurgery for brain metastasis from renal cell carcinoma

“…There are several studies on the usefulness of radiosurgery for brain metastases based on different histologic types. Local tumor control rates were reported to be between 81.5‐100% 11‐16, 18‐28. Some groups stated that RCC brain metastasis, although regarded as more resistant to conventional radiation therapy,29, 30 had a similar or better radiosurgery response than other histologies 11‐15.…”