Dynamic role of CUL4B in radiation-induced intestinal injury-regeneration
Beibei Guo,
Xiaohan Huo,
Xueyong Xie
et al.
Abstract:CUL4B, a crucial scaffolding protein in the largest E3 ubiquitin ligase complex CRL4B, is involved in a broad range of physiological and pathological processes. While previous research has shown that CUL4B participates in maintaining intestinal homeostasis and function, its involvement in facilitating intestinal recovery following ionizing radiation (IR) damage has not been fully elucidated. Here, we utilized in vivo and in vitro models to decipher the role of CUL4B in intestinal repair after IR-injury. Our fi… Show more
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