Dynamic Response of Femoral Cartilage in Knees With Unicompartmental Osteoarthritis

Lesso, Agustín Vidal; Orozco, Elías Rigoberto Ledesma; Lesso‐Arroyo, Raúl; Rodríguez-Castro, Ramón

doi:10.22201/icat.16656423.2011.9.02.445

Cited by 11 publications

(13 citation statements)

References 40 publications

(59 reference statements)

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“…40 However they were lower than human cartilage shear modulus values (2.41 MPa) measured using the same procedure. 55 The average equilibrium value of shear modulus for 12month tissue-engineered cartilage was slightly higher than controls but similar to the equilibrium values for mature bovine cartilage. 40 There was much less scatter in instantaneous shear values compared to equilibrium shear results for controls suggesting that instantaneous shear results, which are a better indicator of tissue characteristics, provide a more consistent measurement to compare tissue.…”

Section: Discussionsupporting

confidence: 59%

Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee

et al. 2016

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Two complete unicondylar surface replacement scaffold designs to support tissue-engineered cartilage growth that utilized adult endogenous stem cells were 3D printed and tested in a dog stifle model. Integrated rosette strain gauges were calibrated and used to determine shear loading within stifle joints for up to 12 months. An activity index that compared extent of daily activity with tissue formation showed differences in the extent and quality of new tissue with the most active animal having the most new tissue formation. Shear loads were highest early and decreased with time indicating that cartilage tissue formation begins while tissues experience high shear loads and continues as the loads decrease toward normal physiological levels. Scaffolds with biomimetic support pegs facilitated the most rapid bone ingrowth and were noted to have more cartilage formation with better quality cartilage as measured using both indentation testing and histology. Comparison of implant placement depth to previous studies suggested that placement depth affects the amount of tissue formation. This study provides measurements of loading patterns and cartilage regeneration on a complete medial condylar surface replacement that can be used for preclinical testing of a tissue engineering approach for the most common form of early stage osteoarthritis, unicondylar disease. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1409-1421, 2017.

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Section: Discussionsupporting

confidence: 59%

Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee

et al. 2016

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“…In addition, the value of Young’s modulus of pericellular matrix around chondrocytes reported in previous studies is in the order to 10–100 kPa [ 50 ]. Furthermore, the elastic modulus of healthy articular cartilage is in the range from 130 to 573 kPa [ 51 ]. However, comprehensive experiments with PVA/SDCM were conducted to evaluate the influence of the SDCM ratio in water uptake/swelling, mechanical properties, and bioprintability of the different formulations.…”

Section: Discussionmentioning

confidence: 99%

Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineering

Setayeshmehr

Hafeez

Blitterswijk

et al. 2021

IJMS

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Various hydrogel systems have been developed as biomaterial inks for bioprinting, including natural and synthetic polymers. However, the available biomaterial inks, which allow printability, cell viability, and user-defined customization, remains limited. Incorporation of biological extracellular matrix materials into tunable synthetic polymers can merge the benefits of both systems towards versatile materials for biofabrication. The aim of this study was to develop novel, cell compatible dual-component biomaterial inks and bioinks based on poly(vinyl alcohol) (PVA) and solubilized decellularized cartilage matrix (SDCM) hydrogels that can be utilized for cartilage bioprinting. In a first approach, PVA was modified with amine groups (PVA-A), and mixed with SDCM. The printability of the PVA-A/SDCM formulations cross-linked by genipin was evaluated. On the second approach, the PVA was functionalized with cis-5-norbornene-endo-2,3-dicarboxylic anhydride (PVA-Nb) to allow an ultrafast light-curing thiol-ene cross-linking. Comprehensive experiments were conducted to evaluate the influence of the SDCM ratio in mechanical properties, water uptake, swelling, cell viability, and printability of the PVA-based formulations. The studies performed with the PVA-A/SDCM formulations cross-linked by genipin showed printability, but poor shape retention due to slow cross-linking kinetics. On the other hand, the PVA-Nb/SDCM showed good printability. The results showed that incorporation of SDCM into PVA-Nb reduces the compression modulus, enhance cell viability, and bioprintability and modulate the swelling ratio of the resulted hydrogels. Results indicated that PVA-Nb hydrogels containing SDCM could be considered as versatile bioinks for cartilage bioprinting.

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“…Characteristic ranges of variation of the shear moduli of cortical bone (2.5 ± 0.8 GPa) [ 27 ] and for articular cartilages (24 ± 3 MPa) [ 28 , 29 ] have been also reported on Figure 2 for comparison with the mechanical behavior of our materials.…”

Section: Resultsmentioning

confidence: 99%

Biomechanically Tunable Nano-Silica/P-HEMA Structural Hydrogels for Bone Scaffolding

et al. 2021

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Innovative tissue engineering biomimetic hydrogels based on hydrophilic polymers have been investigated for their physical and mechanical properties. 5% to 25% by volume loading PHEMA-nanosilica glassy hybrid samples were equilibrated at 37 °C in aqueous physiological isotonic and hypotonic saline solutions (0.15 and 0.05 M NaCl) simulating two limiting possible compositions of physiological extracellular fluids. The glassy and hydrated hybrid materials were characterized by both dynamo-mechanical properties and equilibrium absorptions in the two physiological-like aqueous solutions. The mechanical and morphological modifications occurring in the samples have been described. The 5% volume nanosilica loading hybrid nanocomposite composition showed mechanical characteristics in the dry and hydrated states that were comparable to those of cortical bone and articular cartilage, respectively, and then chosen for further sorption kinetics characterization. Sorption and swelling kinetics were monitored up to equilibrium. Changes in water activities and osmotic pressures in the water-hybrid systems equilibrated at the two limiting solute molarities of the physiological solutions have been related to the observed anomalous sorption modes using the Flory-Huggins interaction parameter approach. The bulk modulus of the dry and glassy PHEMA-5% nanosilica hybrid at 37 °C has been observed to be comparable with the values of the osmotic pressures generated from the sorption of isotonic and hypotonic solutions. The anomalous sorption modes and swelling rates are coherent with the difference between osmotic swelling pressures and hybrid glassy nano-composite bulk modulus: the lower the differences the higher the swelling rate and equilibrium solution uptakes. Bone tissue engineering benefits of the use of tuneable biomimetic scaffold biomaterials that can be “designed” to act as biocompatible and biomechanically active hybrid interfaces are discussed.

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Dynamic Response of Femoral Cartilage in Knees With Unicompartmental Osteoarthritis

Cited by 11 publications

References 40 publications

Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee

Determination of joint loads using new sensate scaffolds for regenerating large cartilage defects in the knee

Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineering

Biomechanically Tunable Nano-Silica/P-HEMA Structural Hydrogels for Bone Scaffolding

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