Dynamic remodeling of white adipose tissue by intermittent fasting

Verma, Navkiran; Thakkar, Nikita; Phillips, Joy; Ealey, Kafi N.; Sung, Hoon‐Ki

doi:10.1016/j.cofs.2020.10.023

Cited by 4 publications

(4 citation statements)

References 60 publications

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“…Furthermore, activation of receptors responsible for immune cytokine signaling such as toll-like receptor 4 exhibit increased ECM deposition and fibrosis (Vila et al, 2014), in part by downregulation of adipogenic marker PPARγ (Wei et al, 2010). Hence, coupled with adipocyte expansion, the microenvironment of obese WAT experiences hypoxia, adipocyte death, dysregulated angiogenesis, ECM deposition, and immune cell infiltration (Verma et al, 2020), overall creating an unhealthy microenvironment. Consequently, this unhealthy microenvironment can inhibit ductal growth, impair mammary gland function, and foster tumor growth (Lin and Li, 2007;Ullah et al, 2017).…”

Section: Adipose Stromal Cells and Cancer Associated Fibroblastsmentioning

confidence: 99%

“…This induces cellular stress and apoptosis of adipocytes. As a result, pro-inflammatory macrophages infiltrate to surround these apoptotic adipocytes while extracellular matrix (ECM) is deposited, resulting in a constitutive state of fibro-inflammation within the tissue (Castoldi et al, 2015;Verma et al, 2020). Intriguingly, fibroinflammation is a hallmark of dysfunctional WAT and is associated with increased cancer incidence (Divella et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…As the mammary gland is composed of WAT, WAT contributes many populations that form the tumor microenvironment. WAT is a heterogeneous tissue composed of adipose stromal cells (ASC), various immune cells, vascular cells, and mammary epithelial cells (Verma et al, 2020). Nutritional excess conditions can alter these microenvironmental populations to favor mammary tumor growth.…”

Section: Introductionmentioning

confidence: 99%

“…Nutritional excess conditions can alter these microenvironmental populations to favor mammary tumor growth. Alterations in ASC regulate adipocyte expansion, inflammation, and ECM formation (Zhang et al, 2019;Verma et al, 2020). Thereby, ASC play a critical role in maintaining tissue integrity (Hillers et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Nutritional Regulation of Mammary Tumor Microenvironment

Thakkar

Shin

Sung

2022

Front. Cell Dev. Biol.

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The mammary gland is a heterogeneous organ comprising of immune cells, surrounding adipose stromal cells, vascular cells, mammary epithelial, and cancer stem cells. In response to nutritional stimuli, dynamic interactions amongst these cell populations can be modulated, consequently leading to an alteration of the glandular function, physiology, and ultimately disease pathogenesis. For example, obesity, a chronic over-nutritional condition, is known to disrupt homeostasis within the mammary gland and increase risk of breast cancer development. In contrast, emerging evidence has demonstrated that fasting or caloric restriction can negatively impact mammary tumorigenesis. However, how fasting induces phenotypic and functional population differences in the mammary microenvironment is not well understood. In this review, we will provide a detailed overview on the effect of nutritional conditions (i.e., overnutrition or fasting) on the mammary gland microenvironment and its impact on mammary tumor progression.

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Section: Adipose Stromal Cells and Cancer Associated Fibroblastsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nutritional Regulation of Mammary Tumor Microenvironment

Thakkar

Shin

Sung

2022

Front. Cell Dev. Biol.

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Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health

Diab,

Dimachkie,

Zein

et al. 2024

Cell Biochem Biophys

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Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has also been rising. Recent research has focused on modalities aimed at reducing obesity. Several modalities have been suggested including behavioral and dietary changes, medications, and bariatric surgery. These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities. Specifically, intermittent fasting (IF) has been gaining interest in the past decade. IF is characterized by cycles of alternating fasting and eating windows, with several different forms practiced. IF has been shown to reduce weight and alleviate obesity-related complications. Our review of clinical and experimental studies explores the effects of IF on the lipid profile, white adipose tissue (WAT) dynamics, and the gut microbiome. Notably, IF corrects dyslipidemia, reduces WAT accumulation, and decreases inflammation, which reduces CVD and obesity. This comprehensive analysis details the protective metabolic role of IF, advocating for its integration into public health practices.

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Various types of fasting diet and possible benefits in nonalcoholic fatty liver: Mechanism of actions and literature update

Mirrazavi,

Behrouz

2024

Clinical Nutrition

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Dynamic remodeling of white adipose tissue by intermittent fasting

Cited by 4 publications

References 60 publications

Nutritional Regulation of Mammary Tumor Microenvironment

Nutritional Regulation of Mammary Tumor Microenvironment

Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health

Various types of fasting diet and possible benefits in nonalcoholic fatty liver: Mechanism of actions and literature update

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