Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection

Botta, Davide; Fuller, Michael J.; Marquez‐Lago, Tatiana T.; Bachus, Holly; Bradley, John E.; Weinmann, Amy S.; Zajac, Allan; Randall, Troy D.; Lund, Frances E.; León, Beatriz; Ballesteros-Tato, André

doi:10.1038/ni.3837

Cited by 197 publications

(328 citation statements)

References 54 publications

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“…[12][13][14]35 However, some other groups have shown that the lack of Tfr cells had no impact on GC size and GC B-cell numbers. In different murine models, absence of Tfr cells led to expansion of Tfh and GC B cells, as well as increased antibody production.…”

Section: Definiti On Of T Follicul Ar Line Ag Ementioning

confidence: 99%

“…In different murine models, absence of Tfr cells led to expansion of Tfh and GC B cells, as well as increased antibody production. [35][36][37][38][39] Thus, it was suggested that Tfr cells impose a more stringent competition for Tfh help on GC B cells, promoting the generation of high affinity antibodies, while limiting the overall expansion of antigen-specific B-cell clones. 36 The impact of Tfr cells on the regulation of antigen-specific B cells and antibody affinity was also addressed.…”

Section: Definiti On Of T Follicul Ar Line Ag Ementioning

confidence: 99%

“…35,[40][41][42][43] Given that several redundant mechanisms were pointed to induce tolerance within GC, it is notable that the absence of Tfr cells alone can be sufficient to induce autoantibody-mediated autoimmunity. 35,[40][41][42][43] Given that several redundant mechanisms were pointed to induce tolerance within GC, it is notable that the absence of Tfr cells alone can be sufficient to induce autoantibody-mediated autoimmunity.…”

Section: Definiti On Of T Follicul Ar Line Ag Ementioning

confidence: 99%

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T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

Fonseca

Ribeiro

Graça

2019

Immunological Reviews

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Summary Germinal centers (GC) have been known as key anatomic structures in humoral immunity, where isotype switching and affinity maturation occur. As a consequence, elucidation of GC regulation has potential implications for the understanding of autoantibody‐mediated diseases. It is now accepted that different regulatory mechanisms coexist, including the action of a specialized population of Foxp3+ regulatory T cells with unique access to the B‐cell follicle: the T follicular regulatory (Tfr) cells. Tfr cells develop through a multistep process requiring migration through different compartments of lymphoid tissues. This review discusses the ontogeny and physiology of Tfr cells, their distribution within distinct anatomic compartments, and their function. A greater understanding of Tfr biology and GC regulation is likely to lead to better stratification of patients with autoantibody‐mediated diseases, and to the identification of novel therapeutic targets.

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Section: Definiti On Of T Follicul Ar Line Ag Ementioning

confidence: 99%

Section: Definiti On Of T Follicul Ar Line Ag Ementioning

confidence: 99%

Section: Definiti On Of T Follicul Ar Line Ag Ementioning

confidence: 99%

See 1 more Smart Citation

T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

Fonseca

Ribeiro

Graça

2019

Immunological Reviews

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“…68 Therefore, IL-2 in the local microenvironment is essential to determine the fate of CD4 + T cell differentiation. 73 The interplay between IL-2 and TFR needs further studies. 71 The suboptimal IL-2 signaling in T1D not only reduced the number, but also impaired the function of Treg cells.…”

Section: Suboptimal Il-2 Signalingmentioning

confidence: 99%

Follicular helper T cells in type 1 diabetes

Shao

Zheng

et al. 2019

FASEB j.

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Type 1 diabetes (T1D) is an autoimmune disease caused by the dysfunction of immune system and consequently the destruction of insulin‐producing β cells. In past decades, numerous studies have uncovered that CD4+ T cell subsets are critical in the pathogenesis of T1D, manifesting that type 1 T helper (Th1) and Th17 cells are pathogenic, while regulatory T (Treg) cells and Th2 cells are protective. More recently, the pathogenic role of another subset, follicular helper T (Tfh) cells that essentially regulate germinal center (GC) formation and humoral responses, has also been demonstrated in T1D and many other autoimmune diseases. In this review, we summarize the evidence for the aberrant differentiation and function of Tfh cells in T1D, and also discuss the underlying mechanisms. A better understanding on the pathogenic role of Tfh cells in T1D will inspire the design of potential therapeutic strategies to target this subset in the future.

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“…The clustering together of TFH-like cells and FoxP3 + Helios + regulatory T cells further raises the possibility that T follicular regulatory cells are also present 43,44 . A distinct set of effector CD4 + T cells could be …”

Section: Cc-by-nc-nd 40 International Licensementioning

confidence: 99%

The immune cell landscape in kidneys of lupus nephritis patients

Arazi

Rao

Berthier

et al. 2018

Preprint

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Lupus nephritis is a potentially fatal autoimmune disease, whose current treatment is ineffective and often toxic. To gain insights into disease mechanisms, we analyzed kidney samples from lupus nephritis patients and healthy controls using single-cell RNA-seq. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid, T, NK and B cells, demonstrating both pro-inflammatory and resolving responses. We found evidence of local activation of B cells correlated with an age-associated B cell signature, and of progressive stages of monocyte differentiation within the kidney. A clear interferon response was observed in most cells. Two chemokine receptors, CXCR4 and CX3CR1, were broadly expressed, pointing to potential therapeutic targets. Gene expression of immune cells in urine and kidney was highly correlated, suggesting urine may be a surrogate for kidney biopsies. Our results provide a first comprehensive view of the complex network of leukocytes active in lupus nephritis kidneys.

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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection

Cited by 197 publications

References 54 publications

T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

Follicular helper T cells in type 1 diabetes

The immune cell landscape in kidneys of lupus nephritis patients

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