Dynamic Regulation of Pacemaker Activity by the Na+:K+ Pump

Abstract

Abstract

Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk

“…Population-based approaches have been widely adopted in the recent years in the field of computational cardiac electrophysiology [1], [2], [3], [4], [5], [6], [7], [8]. The classical analysis performed with a single action potential (AP) model has been extended to the study of the properties emerging in a broad group of models (called “population”).…”

“…A different statistical process, the multivariable logistic regression, can be used instead when the outputs of interest are described as Boolean variables (i.e., yes/no, true/false, presence/absence) [2], [8]. This analysis allows estimating how perturbations in model parameters affect the probability that a certain dichotomous outcome will occur.…”

“…For example, this predictive method has been applied successfully to analyze a stochastic model of Ca 2+ sparks in the ventricular cell [2], and to investigate the drug-induced loss of automaticity in a deterministic model of the sinoatrial myocyte [8]. By using receiver operator characteristic analysis, Lee et al .…”