Dynamic regulation of microRNA expression following Interferon-γ-induced gene transcription

Reinsbach, Susanne; Nazarov, Petr V.; Philippidou, Demetra; Schmitt, Martina; Wienecke-Baldacchino, Anke; Muller, Arnaud; Vallar, Laurent; Behrmann, Iris; Kreis, Stephanie

doi:10.4161/rna.20494

Cited by 39 publications

(48 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interferon γ inhibits malignant cell growth by activating transcriptional factor STAT1. Following interferon γ stimulation by infection or UV light STAT1 induction ensues 15 causing formation of homodimers of the factor and their binding to GAS (IFN γ -activated sequences) element in the promoter region of target genes 16 . Predicted promoter region of pri-miR-29a/b-1 contains five GAS elements.…”

Section: Regulation Of Mir-29 Expressionmentioning

confidence: 99%

The role of miR-29 family members in malignant hematopoiesis

Kollinerová¹,

Vassanelli²,

Modrianský³

2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Aims. MicroRNAs of the miR-29 family members were one of the first microRNAs identified as possible therapeutic agents in malignant hematopoiesis. The aim of our review is to summarize the current state of knowledge on miR-29 family members. Methods. We performed literature searches involving miR-29 family members and their relationship to individual hematological malignancies, namely acute myeloid leukemia (AML), chronic lymphoblastic leukemia (CLL) and chronic myeloid leukemia (CML). We also searched for subgroups of hematological malignancies, e.g. multiple myeloma, that are regarded as members of the acute or chronic types of leukemias. Results. A number of genes appear to be regulated by miR-29 family members in various physiological and pathological situations. In our view regulation of Tcl-1, Mcl-1 and DNA methyltransferases is relevant in case of hematological malignancies, hence these are the focus of this review. miR-29 family members also function during normal T-cell and B-cell development. Conclusion. MiR-29 family members appear to govern some general features in commonly heterogenous hematological malignancies and therefore form a potential target for treatment.

show abstract

Section: Regulation Of Mir-29 Expressionmentioning

confidence: 99%

The role of miR-29 family members in malignant hematopoiesis

Kollinerová¹,

Vassanelli²,

Modrianský³

2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

show abstract

“…A plethora of p53-mediated interactions with the innate immune defense system [64][65][66][67] points to a function of p53 leading to immune homeostasis and/or inflammatory disease, which both are associated with hepatocyte senescence, lipid turnover, as well as a recruitment/attraction of natural killer (NK) cells [68,69]. This persistence of "senescence" characterizing the cross-talk between white adipose tissue (WAT) and the liver does not facilitate the elimination/removal of the senescent cells; however, the p53-related promotion of adipose tissue adipogenesis with the development of NAFLD is allowed to take place.…”

Section: Food Restriction Organ Crosstalk In Obese/diabetic "Mice Andmentioning

confidence: 99%

“…Furthermore, the focus on α-synuclein and its impact on the immune system in the periphery [69,70] and CNS [71,72] have emerged as knowledge about its regulatory impact on p53 transcriptional regulation of apoptosis has increased. Sirt1-mediated effects on hepatic α-synuclein and amyloid-β turnover are closely linked to LPS [72], metabolic diseases, as well as obesity, with observed impact on p53 transcriptional regulation by both α-synuclein and amyloid-β metabolism in the liver and brain [73][74][75][76][77].…”

Section: Lps Modulation Of Sirt1/p53 Interactions Is Coupled To Fat Imentioning

confidence: 99%

“…The suppression of Sirt1 expression by dietary fat is now associated with an abnormal p53 mediated posttranscriptional regulation of NK cells [69,83]. Furthermore, dietary fat may facilitate the absorption of LPS in rodents, but also man, by modulating the suppression of Sirt1 effects, while also promoting p53-mediated cell death.…”

Section: Nutrigenomic Diets Block Both Hepatic and Adipose Tissue Dammentioning

confidence: 99%

See 1 more Smart Citation

Introductory Chapter: Obesity—“OMICS” and Endocrinology

Gordeladze¹

2017

Adiposity - Omics and Molecular Understanding

View full text Add to dashboard Cite

“…A main regulatory role of IFN-γ signaling is attributed to miRNAs, affecting genes involved in proliferation, differentiation, signal transduction, immune response, and carcinogenesis [50,95].…”

Section: Control Of the Ifn-γ Pathway By Mirnasmentioning

confidence: 99%

The Role of Immune Modulatory MicroRNAs in Tumors

Seliger¹,

Meinhardt²,

Falke³

2016

RNA Interference

View full text Add to dashboard Cite

Tumors could evade the control of CD8 + T and/or NK cell-mediated surveillance by distinct immune escape strategies. These include the aberrant expression of HLA class I antigens, coinhibitory or costimulatory molecules, and components of the interferon (IFN) signal transduction pathway. In addition, alterations of the tumor microenvironment could interfere with a proper antitumoral immune response by downregulating or inhibiting the frequency and/or activity of immune effector cells and professional antigen presenting cells. Based on the identification as major mediators of the posttranscriptional silencing of gene expression, microRNAs (miRNAs) have been suggested to play a key role in many biological processes known to be involved in neoplastic transformation. Indeed, miRNA expression is frequently deregulated in many cancer types and could have tumor-suppressive as well as oncogenic potential. This review focused on the characterization of miRNAs, which are involved in the control of the immune surveillance or immune escape of tumors and their use as potential diagnostic and prognostic biomarkers as well as therapeutic targets. Moreover, miRNAs can have dual activities by affecting the neoplastic and immunogenic phenotype of tumors.

show abstract

Dynamic regulation of microRNA expression following Interferon-γ-induced gene transcription

Abstract: Kreis (2012) Dynamic regulation of microRNA expression following Interferon-γ-induced gene transcription, RNA Biology, 9:7, 978-989,

Cited by 39 publications

References 59 publications

The role of miR-29 family members in malignant hematopoiesis

The role of miR-29 family members in malignant hematopoiesis

Introductory Chapter: Obesity—“OMICS” and Endocrinology

The Role of Immune Modulatory MicroRNAs in Tumors

Contact Info

Product

Resources

About