Dynamic protein hydrogel with supramolecularly enveloped kartogenin promotes cartilage regeneration through mitochondrial activation

Yin, Wang; Liu, Yang; Hou, Mingzhuang; Shi, Qin; Liu, Tao; Wang, Miao; Yang, Huilin; Pan, Guoqing; He, Fan; Zhang, Yijian

doi:10.1016/j.compositesb.2022.110257

Cited by 8 publications

(6 citation statements)

References 60 publications

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“…[321,322] Emerging research suggests that the endogenous and exogenous detrimental impact on mitochondrial function is a key factor contributing to BMSCs dysfunction, thereby hindering the process of osteogenesis. [323] The harsh microenvironment of bone disease, including high levels of ROS, inflammation, and undernutrition, limited the Active ingredient Cartilage regeneration Au-Gel@KGN [ 329] Injection ---Kartogenin Diabetic bone defects Met@ZIF-8 [ 332] --≈120-160 -metformin Diabetic fracture DFO@Scaffold [321] --≈140 (DFO@PEGA-Lipo) -Deferoxamine…”

Section: Bone Diseasesmentioning

confidence: 99%

“…Modifying implants with mitochondria-remedying NPs can benefit osseointegration against harsh microenvironments. [209,[324][325][326][327][328][329][330][331] For example, Chen et al constructed a bone microenvironment-responsive biofunctional metal-organic framework (bio-MOF) for titanium (Ti) implants to promote new bone formation (Figure 19A). This bio-MOF was formed by the coordination between p-xylylenebisphosphonate (PXBP) and Ce/Sr ions (Ce/SrMOF), where the antiosteoclastic functions of PXBP, CAT, and SOD-like antioxidant activity of Ce, and mitochondrial dynamics modulation of Sr were included.…”

Section: -Octyl Itaconatementioning

confidence: 99%

“…Modifying implants with mitochondria‐remedying NPs can benefit osseointegration against harsh microenvironments. [ 209,324–331 ] For example, Chen et al. constructed a bone microenvironment‐responsive biofunctional metal‐organic framework (bio‐MOF) for titanium (Ti) implants to promote new bone formation ( Figure A).…”

Section: Application Of Mitochondria‐remedying Nanodrugs In Diseasesmentioning

confidence: 99%

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Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Long,

Liu,

Nan

et al. 2024

Advanced Materials

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Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital functions across diverse cellular processes. Dysfunctions within mitochondria serve as catalysts for various diseases, prompting widespread cellular demise. Mounting research on remedying damaged mitochondria indicates that mitochondria constitute a valuable target for therapeutic intervention against diseases. But the less clinical practice and lower recovery rate imply the limitation of traditional drugs, which need a further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution and high efficacy by capitalizing on excellent nanomaterials and targeting drug delivery. Mitochondria‐remedying nanodrugs have achieved ideal therapeutic effects. In this review, we have elucidated the significance of mitochondria in various cells and organs, while also compiling mortality data for related diseases. Correspondingly, nanodrug‐mediate therapeutic strategies and applicable mitochondria‐remedying nanodrugs in disease were detailed, with a full understanding of the roles of mitochondria dysfunction and the advantages of nanodrugs. In addition, the future challenges and directions have been widely discussed. In conclusion, this review provides comprehensive insights into the design and development of mitochondria‐remedying nanodrugs, aiming to help scientists who desire to extend their research fields and engage in this interdisciplinary subject.This article is protected by copyright. All rights reserved

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Section: Bone Diseasesmentioning

confidence: 99%

Section: -Octyl Itaconatementioning

confidence: 99%

Section: Application Of Mitochondria‐remedying Nanodrugs In Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Long,

Liu,

Nan

et al. 2024

Advanced Materials

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“…Coordination interactions can also be used to fabricate functional dynamic hydrogels. Recently, our group prepared dynamic hydrogels with small-molecule compounds by using the coordination of Au and S to boost chondrogenesis [ 86 ]. The hydrogel design mainly involved the coordination between collagen and metal ions ( Fig.…”

Section: Strategies For Nano-crosslinked Dynamic Hydrogel Fabricationmentioning

confidence: 99%

“…(D) In vivo injection of hydrogel facilitates cartilage repair following injury through refinement of mitochondrial polarization and redox balance. Reproduced with permission [86]. Copyright 2022, Elsevier B.V. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)…”

Section: Strategies For Nano-crosslinked Dynamic Hydrogel Fabricationmentioning

confidence: 99%

Nano-crosslinked dynamic hydrogels for biomedical applications

Wang¹,

Zhang²,

Ma³

et al. 2023

Materials Today Bio

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Dynamic Proteinaceous Hydrogel Enables In‐Situ Recruitment of Endogenous TGF‐β1 and Stem Cells for Cartilage Regeneration

Guo,

Yin,

Wang

et al. 2024

Adv Funct Materials

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Articular cartilage is a tissue with relatively poor self‐regeneration capacity due to insufficient blood vessels and chondrocytes in the region. Biomaterial‐assisted tissue engineering has shown great potential in cartilage regeneration. However, there are still many worries over the uses of exogenous growth factors, stem cells and scaffolds. To address these concerns, here a dynamic proteinaceous hydrogel with a self‐recruiting ability of cartilage‐inducing factor for in situ cartilage regeneration is reported. The dynamic hydrogel (Pep‐GelSH) is prepared by using thiol‐modified gelatin and thiol‐capped TGF‐β1‐affinity peptide through the Au‐S coordination. The injectability and self‐recovery of Pep‐GelSH hydrogel enabled not only minimally invasive implantation but also the adaptability of the scaffold to irregular defect shapes. Meanwhile, the dynamic hydrogel showed improved adherence to the host tissue and allowed quick infiltration of host cells. More importantly, the hydrogel significantly enhanced local enrichment of endogenous TGF‐β1 and led to the recruitment of stem cells in vivo. After implantation, the hydrogel scaffold triggered the innate repair capacity of cartilage defects by successively promoting stem cells recruitment, infiltration and differentiation, resulting in significantly enhanced chondrogenesis and improved cartilage repair. Therefore, the study in this work may provide a feasible and promising approach for in situ cartilage regeneration.

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Dynamic protein hydrogel with supramolecularly enveloped kartogenin promotes cartilage regeneration through mitochondrial activation

Cited by 8 publications

References 60 publications

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Nano-crosslinked dynamic hydrogels for biomedical applications

Dynamic Proteinaceous Hydrogel Enables In‐Situ Recruitment of Endogenous TGF‐β1 and Stem Cells for Cartilage Regeneration

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