Dynamic prostatic and laser-ablated lesion volume change after transperineal laser ablation in canine: preliminary observation and its clinical significance

Liu, Ruiqing; Liu, Ji‐Bin; Duan, Shaobo; Cheng, Si-Guo; Chang, Zhiyang; Cao, Huicun; Cao, Guoquan; Li, Yaqiong; Li, Na; Zhang, Lianzhong

doi:10.1080/02656736.2020.1842517

Cited by 8 publications

(9 citation statements)

References 39 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there some similar reports about the change of volume after thermal ablation in other organs [21][22][23][24][25], the exact mechanism has never been clear. We have previously reported that vascular permeability of microcirculation and micro vascular thrombosis around the ablation lesions may be involved in the progress of tissue damage, and then volume of coagulated necrosis gradually expanded with time [15]. Besides, maybe the changes of mircroenvironemt and in ammatory response were involved in the volume change.…”

Section: Discussionmentioning

confidence: 94%

“…The equipments used were described in previous [14,15]. The ultrasound system equipped with a transrectal dual-plane probe (E14CL4b) and contrasted tuned imaging mode (CnTI) (BK3000; B-K Medical Systems, Inc., Peabody, MA, USA) was used in this study.…”

Section: Equipmentmentioning

confidence: 99%

“…The use of glycerine enema for bowel cleansing is convenient for better observation of the prostate by transrectal probe. The protocol of anesthesia is as follow, which was similar to our previous literatures [14,15]. Anesthesia was induced by the intramuscular injection of 8 mg/kg dexmedetomidine (Hengrui Pharmaceutical Co., LTD, Shanghai, China) and 2 mg/kg Zoletil 50 (Virbac Inc., Carros, France).…”

Section: Preoperative Preparationmentioning

confidence: 99%

See 2 more Smart Citations

The change of microenvironment induced by different thermal ablation in prostate and their clinical significances

Liu

Cao

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: To compare the microenvironment change of three type thermal ablation: transperineal laser ablation (TPLA), radiofrequency ablation (RFA) and microwave ablation (MWA) application canine prostate and their clinical significances. Methods: Nine beagles were randomly assigned to TPLA, RFA and MWA group. The ablation was operated in prostate. The level of cytokine (TNF-α, IL-12, TGF-β1 and IL-10) in serum was detected at four time point (before ablation, immediately, one week and one month after ablation). The positive cells of macrophages in the border of ablation lesions were detected. Results: One week after ablation, the levels of pro-inflammatory cytokine (TNF-α) in the TPLA group was the highest, followed by the RFA group, and the MWA group was the lowest (159.11 ± 53.26 pg/ml, 129.57 ± 23.42 pg/ml, 53.65 ± 21.34 pg/ml, P＜0.03). However, one month later, the level of TNF-α had a continuous increase in TPLA group while which showed a significant decrease trend in other groups. The levels of anti-inflammatory cytokine (TGF-β1) in the TPLA group was significantly lower than other two groups (48.92 ± 48.67 pg/ml, 218.85 ± 27.56 pg/ml, 167.67 ± 45.67 pg/ml, P＜0.05). M1-like macrophages were dominant in TPLA group, and M2-like macrophages were dominant in RFA and MWA groups. Conclusion: Microenvironment changes in the TPLA group were mainly pro-inflammatory, while anti-inflammatory responses were observed in the RFA and MWA groups.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Equipmentmentioning

confidence: 99%

Section: Preoperative Preparationmentioning

confidence: 99%

See 1 more Smart Citation

The change of microenvironment induced by different thermal ablation in prostate and their clinical significances

Liu

Cao

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…According to studies conducted in animal models, prostate volume immediately after TPLA could be greater than before treatment. This is probably attributable to an inflammatory response in the laser-ablated tissue which could be involved in the progression of the tissue damage (and thus relief from BPO is achieved at longer follow-up) [20].…”

Section: Discussionmentioning

confidence: 99%

Ejaculatory function following transperineal laser ablation vs TURP for benign prostatic obstruction: a randomized trial

et al. 2023

View full text Add to dashboard Cite

To evaluate the reliability of transperineal interstitial laser ablation of the prostate (TPLA) in preserving antegrade ejaculation compared to transurethral resection of the prostate (TURP). Patients and MethodsIn this single-centre, prospective, randomized, open-label study, consecutive patients with indication for surgical treatment for benign prostatic obstruction (BPO) were enrolled between January 2020 and September 2021 (NCT04781049). Patients were randomized to one of two treatment arms: Group A: TPLA (experimental group) and Group B: TURP (reference standard group). The primary endpoint was change in ejaculatory function (assessed by the Male Sexual Health Questionnaire -Ejaculatory function domain [EJ-MSHQ]) at 1 month after surgery. Secondary endpoints included comparison of visual analogue scale (VAS) scores, changes in sexual function (assessed using the five-item International Index of Erectile Function [IIEF-5]), change in International Prostate Symptom Score [IPSS], change in quality of life score, and maximum urinary flow rate [Q max ] improvement at 1-6 months, as appropriate. ResultsFifty-one patients (26 TPLA vs 25 TURP) were analysed. No differences in the perception of pain assessed by VAS and no differences in IIEF-5 score were found between the groups. The distribution of ejaculatory function assessed by the EJ-MSHQ remained unmodified after TPLA (P = 0.2), while a median 30% decrease in EJ-MSHQ score was observed after TURP (P = 0.01). Absence of antegrade ejaculation was reported in one patient in the TPLA group (vs 18 patients in the TURP group). A statistically significant difference between the treatment groups was found in terms of postoperative Q max .3] mL/s vs 26.0 [interquartile range 22.0-48.0] mL/s; P < 0.001). Both treatments significantly improved Q max , with a mean 23.9 mL/s improvement after TURP (95% confidence interval [CI] 17.1-30.7) vs 6.0 mL/s after TPLA (95% CI 5.0-7.0), and IPSS, with a mean decrease of 11.6 (95% CI 9.7-13.5) vs 5.8 after TPLA (95% CI.2-9.6) with respect to baseline. ConclusionIn our study, TPLA preserved ejaculatory function in 96% of cases in addition to providing significant relief from BPO.

show abstract

“…The use of TRUS guidance with a biplane probe allows repositioning of applicators during the manoeuvre based on the physician experience, and the amount of energy is planned in advance according to the baseline volume of the prostatic lobes (35,38,49). The assessment of the extent of the coagulation zone after ablation with transrectal contrastenhanced ultrasonography is considered a very useful tool for early result assessment (50)(51)(52). Therefore, ultrasonography plays an important role in the study.…”

Section: Discussionmentioning

confidence: 99%

The Design and Rationale of a Multicentre Randomised Controlled Trial Comparing Transperineal Percutaneous Laser Ablation With Transurethral Resection of the Prostate for Treating Benign Prostatic Hyperplasia

Zhang

Guo

et al. 2021

Front. Surg.

View full text Add to dashboard Cite

Background: Transurethral resection of the prostate (TURP) is regarded as the “gold standard” for the treatment of benign prostatic hyperplasia (BPH) in elderly men. However, ~15% of patients who had undergone TURP had intraoperative and postoperative complications, such as bleeding, urinary incontinence and urethral stricture. Transperineal percutaneous laser ablation (TPLA) is a method that places the optical fibre directly into the prostate with the guidance of ultrasound imaging, and the percutaneous transperineal approach is performed distal to the urethra and rectum to protect these structures and reduce urethral or postoperative infection. Several studies on TPLA for BPH treatment have been reported recently; however, high-quality randomised controlled trial (RCT) to evaluate its efficacy, safety, and long-term follow up remain absent.Methods: This study is a multicentre, open-label RCT to assess the efficacy and safety of TPLA vs. TURP to treat BPH. We hypothesise that the TPLA has non-inferior efficacy to TURP in the International Prostate Symptom Score (IPSS) at 3 months changing from the baseline and lower incidence of post-surgery complications. One hundred and fourteen patients with BPH will be recruited at 19 sites and randomly assigned at 1:1 to TPLA or TURP groups. The patients will be followed up at 1, 3, 6, 12, and 24 months after the procedure.Discussion: The study will be the first multicentre clinical trial including 16 participating centres in China, Italy, Switzerland, and Poland with relatively large sample size 114. By comprehensively compare the safety and efficacy of TPLA with TURP in patients with BPH, especially concerning the improvement of lower urinary tract symptoms (LUTS) and complication incidence, the study will help to illustrate the clinical value of TPLA and provide a beneficial alternative treatment for BPH patients.Clinical Trial Registration: The study has been registered on Chinese Clinical Trial Registry (http://www.chictr.org.cn), identifier [ChiCTR1900022739].

show abstract

Dynamic prostatic and laser-ablated lesion volume change after transperineal laser ablation in canine: preliminary observation and its clinical significance

Cited by 8 publications

References 39 publications

The change of microenvironment induced by different thermal ablation in prostate and their clinical significances

The change of microenvironment induced by different thermal ablation in prostate and their clinical significances

Ejaculatory function following transperineal laser ablation vs TURP for benign prostatic obstruction: a randomized trial

The Design and Rationale of a Multicentre Randomised Controlled Trial Comparing Transperineal Percutaneous Laser Ablation With Transurethral Resection of the Prostate for Treating Benign Prostatic Hyperplasia

Contact Info

Product

Resources

About