Dynamic Plasmonic System That Responds to Thermal and Aptamer-Target Regulations

Zhou, Chao; Xin, Ling; Duan, Xiaoyang; Urban, Maximilian J.; Liu, Na

doi:10.1021/acs.nanolett.8b03807

Cited by 80 publications

(94 citation statements)

References 46 publications

(89 reference statements)

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“…Recently developed plasmonic metamolecules [25] in contrast, generate CD at visible wavelengths, which enables detection of plasmonic CD and conformational changes of the metamolecules in an undisturbed optical region. This concept of high-sensitivity detection of RNA molecules [35] and detection of small molecules like cocaine and ATP [36] have been exploited by our research group and by other authors, in recent years. Here, we extended this approach for the detection of proteins.…”

Section: Resultsmentioning

confidence: 99%

Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing

2019

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DNA nanotechnology offers the possibility to rationally design structures with emergent properties by precisely controlling their geometry and functionality. Here, we demonstrate a DNA-based plasmonic metamolecule that is capable of sensing human thrombin proteins. The chiral reconfigurability of a DNA origami structure carrying two gold nanorods was used to provide optical read-out of thrombin binding through changes in the displayed plasmonic circular dichroism. In our experiments, each arm of the structure was modified with one of two different thrombin-binding aptamers—thrombin-binding aptamer (TBA) and HD22—in such a way that a thrombin molecule could be sandwiched by the aptamers to lock the metamolecule in a state of defined chirality. Our structure exhibited a Kd of 1.4 nM, which was an order of magnitude lower than those of the individual aptamers. The increased sensitivity arose from the avidity gained by the cooperative binding of the two aptamers, which was also reflected by a Hill coefficient of 1.3 ± 0.3. As we further exploited the strong plasmonic circular dichroism (CD) signals of the metamolecule, our method allowed one-step, high sensitivity optical detection of human thrombin proteins in solution.

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Section: Resultsmentioning

confidence: 99%

Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing

2019

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“…Another benefit afforded by DNA nanotechnology is its unique capability to reconfigure structures with different stimuli including DNA, [35][36][37][38][39][40][41][42] RNA, [43,44] aptamers, [45,46] light, [47][48][49][50] pH, [48,51,52] temperature, [46,53] among others. [5,54,55] Figure 3b shows one of the examples, in which light is adopted as stimulus.…”

Section: Solution-based Reconfiguration Strategiesmentioning

confidence: 99%

Reconfigurable Plasmonic Chirality: Fundamentals and Applications

2020

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Molecular chirality is a geometric property that is of great importance in chemistry, biology, and medicine. Recently, plasmonic nanostructures that exhibit distinct chiroptical responses have attracted tremendous interest, given their ability to emulate the properties of chiral molecules with tailored and pronounced optical characteristics. However, the optical chirality of such human‐made structures is in general static and cannot be manipulated postfabrication. Herein, different concepts to reconfigure the chiroptical responses of plasmonic nano‐ and micro‐objects are outlined. Depending on the utilized strategies and stimuli, the chiroptical signature, the 3D structural conformation, or both can be reconfigured. Optical devices based on plasmonic nanostructures with reconfigurable chirality possess great potential in practical applications, ranging from polarization conversion elements to enantioselective analysis, chiral sensing, and catalysis.

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“…Another important application of metasurface is the optical encryption [44][45][46][47]. While such kind of functions have been realized with conventional color nanoprinters, very complicated post-fabrication treatments are usually required, e.g.…”

Section: The Nonlinear Nanoprinting and Optical Encryptionmentioning

confidence: 99%

Resonance-enhanced three-photon luminesce via lead halide perovskite metasurfaces for optical encoding

et al. 2019

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Lead halide perovskites have emerged as promising materials for photovoltaic and optoelectronic devices. However, their exceptional nonlinear properties have not been fully exploited in nanophotonics yet. Herein we fabricate methyl ammonium lead tri-bromide perovskite metasurfaces and explore their internal nonlinear processes. While both of third-order harmonic generation and three-photon luminescence are generated, the latter one is less affected by the material loss and has been significantly enhanced by a factor of 60. The corresponding simulation reveals that the improvement is caused by the resonant enhancement of incident laser. Interestingly, such kind of resonance-enhanced three-photon luminescence holds true for metasurfaces with a small period number of 4, enabling promising applications of perovskite metasurface in high-resolution nonlinear color nanoprinting and optical encoding. The encoded information ‘NANO’ is visible only when the incident laser is on-resonance. The off-resonance pumping and the single-photon excitation just produce a uniform dark or photoluminescence background.

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Dynamic Plasmonic System That Responds to Thermal and Aptamer-Target Regulations

Cited by 80 publications

References 46 publications

Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing

Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing

Reconfigurable Plasmonic Chirality: Fundamentals and Applications

Resonance-enhanced three-photon luminesce via lead halide perovskite metasurfaces for optical encoding

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