Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET

Lan, Xiaoli; Fan, Kevin; Li, Ké; Cai, Weibo

doi:10.1007/s00259-021-05214-5

Cited by 17 publications

(21 citation statements)

References 28 publications

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“…With comparable image quality and kinetic analysis, the total-body scanner provides a variety of advantages with ultra-low-activity FDG, such as a smaller median effective radiation dose (owing to a lower dose of FDG). Moreover, it provides a 10-fold reduction in the file size of the raw PET data, and faster data processing, reconstruction, and transport [ 12 ].…”

Section: Major Advantages Of Total-body Pet Scannersmentioning

confidence: 99%

Advantages and Applications of Total-Body PET Scanning

Katal¹,

Eibschutz

Saboury

et al. 2022

Diagnostics

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Recent studies have focused on the development of total-body PET scanning in a variety of fields such as clinical oncology, cardiology, personalized medicine, drug development and toxicology, and inflammatory/infectious disease. Given its ultrahigh detection sensitivity, enhanced temporal resolution, and long scan range (1940 mm), total-body PET scanning can not only image faster than traditional techniques with less administered radioactivity but also perform total-body dynamic acquisition at a longer delayed time point. These unique characteristics create several opportunities to improve image quality and can provide a deeper understanding regarding disease detection, diagnosis, staging/restaging, response to treatment, and prognostication. By reviewing the advantages of total-body PET scanning and discussing the potential clinical applications for this innovative technology, we can address specific issues encountered in routine clinical practice and ultimately improve patient care.

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Section: Major Advantages Of Total-body Pet Scannersmentioning

confidence: 99%

Advantages and Applications of Total-Body PET Scanning

Katal¹,

Eibschutz

Saboury

et al. 2022

Diagnostics

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show abstract

“…These costs might be compensated for if the camera can be used as a high throughput system for regular patient care. Usually, business cases for the acquisition of an extended FOV PET camera are based on the fact that more patients can be scanned, because of the shorter acquisition times [ 11 ]. Usually, the situation that scans may take longer as a result of a lower injected dose or longer waiting time after injection is not taken into account.…”

Section: Consequences Of New Extended Fov Features For Application Of...mentioning

confidence: 99%

“…When imaging with an extended FOV PET-camera, an at least 8–10 times reduction of the injected dose is expected to produce equivalent or even better images than the current state-of-the-art PET scanners. This would correspond to making PET scanning available to healthy volunteers [ 11 , 12 ] – as long as the CT image is only necessary for attenuation correction. Another consequence of dose reduction is the possibility of imaging the same patient during more sessions, which leads to the use of PET more regularly as a tool for accurate therapy evaluation and planning.…”

Section: New Features Of Extended Field-of-view Pet Camerasmentioning

confidence: 99%

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Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals?

2022

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With the rapid emergence of extended Field-of-View PET-cameras several new applications for radiopharmaceuticals become within reach. Main reason is the significant increase of the sensitivity of the PET-camera so that much less radioactivity can be administered. Issues that that hampered development or use of PET-radiopharmaceuticals become realistic again. Molar activity requirements can become less strict. New low-yielding radiochemistry methods may become applicable. Carbon-11 labelled compounds can revive and potentially be shipped to nearby PET-facilities. PET-radiopharmaceuticals with slow kinetics in comparison to their half life can still be used. As additional infrastructure and equipment will likely remain unchanged and keep the same sensitivity therefore there will be issues with kinetic modelling requiring analysis of plasma or metabolites samples with lower count rate. Besides the potential revival of failed radiopharmaceuticals, novel challenges are ahead to develop novel radiochemistry based on thus far unsuitable (low yielding or time consuming) reactions.

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“…Despite that whole-body dPET collected with either continuous bed motion or step-and-shoot multi-bed position provides a key measure to perform the precise diagnosis at locoregional area [16][17][18][19], the synchronized acquisition of temporal and spatial information is under expectation. With the advent of the total-body PET/CT scanner with a 194-cm long AFOV (uEXPLORER, United Imaging Healthcare, China), it is possible to collect both pathological and physiological information for the entire human body in one bed position [4,[20][21][22]. Additionally, the high PET sensitivity of the total-body scanner allows to generate time-activity curves (TACs) with ne structure.…”

Section: Introductionmentioning

confidence: 99%

Is Dynamic Total-body PET Imaging Feasible in the Clinical Daily Practice?

Chen

et al. 2021

Preprint

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PurposeDynamic PET (dPET) imaging of multi-temporal frames can quantitate tracer kinetics and has been mostly used in the research rather than clinical daily practice due to the long acquisition time. The total-body PET/CT scanner can generate fine time-activity curves (TACs) in dPET imaging and provide tempo-spatially synchronized pharmacokinetics in the entire human body. To investigate the feasibility in daily practice, the study aimed to explore the shortest acquisition time of dPET imaging. MethodsTen patients who underwent an 18F-FDG total-body dPET examination were retrospectively enrolled. Both the Patlak graphic analysis (Ki) and irreversible two tissues compartment model (i2TCM) analysis (K1, k2, k3) were used to calculate the kinetic parameters with different shortened acquisition durations. These kinetic parameters at various organs/tissues and lesions were compared with those obtained from the reference 60min acquisition. In addition, a hybrid approach combining the initial 20-min dPET data and the static PET scan at 55-60 min post-injection was proposed, and the kinetic parameters were calculated and compared with the references. ResultsPatlak Ki derived from the first 50-min dPET acquisition showed no significant difference in healthy organs/tissues compared with the reference (all p > 0.05), while the lesions can be visually distinguished even in the initial 20-min Ki images. In the i2TCM analysis, the kinetic parameters — K1, k2, k3 of 30-min dPET acquisition showed no significant difference for healthy organs/tissues and lesions compared to 60-min dPET acquisition (all p > 0.05). The kinetic parameters obtained from the proposed hybrid approach can provide reliable kinetic parameters as well as those obtained in the static PET imaging. ConclusionsThe dPET total-body imaging can be shortened to 30 min to generate reliable kinetic parameters with i2TCM. Additionally, the hybrid approach provides both robust tracer metabolic information and the conventional standard uptake values (SUVs), demonstrating its feasibility in clinical practice.

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Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET

Cited by 17 publications

References 28 publications

Advantages and Applications of Total-Body PET Scanning

Advantages and Applications of Total-Body PET Scanning

Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals?

Is Dynamic Total-body PET Imaging Feasible in the Clinical Daily Practice?

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