2021
DOI: 10.1007/s00259-021-05214-5
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Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET

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Cited by 17 publications
(21 citation statements)
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References 28 publications
(49 reference statements)
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“…With comparable image quality and kinetic analysis, the total-body scanner provides a variety of advantages with ultra-low-activity FDG, such as a smaller median effective radiation dose (owing to a lower dose of FDG). Moreover, it provides a 10-fold reduction in the file size of the raw PET data, and faster data processing, reconstruction, and transport [ 12 ].…”
Section: Major Advantages Of Total-body Pet Scannersmentioning
confidence: 99%
“…With comparable image quality and kinetic analysis, the total-body scanner provides a variety of advantages with ultra-low-activity FDG, such as a smaller median effective radiation dose (owing to a lower dose of FDG). Moreover, it provides a 10-fold reduction in the file size of the raw PET data, and faster data processing, reconstruction, and transport [ 12 ].…”
Section: Major Advantages Of Total-body Pet Scannersmentioning
confidence: 99%
“…These costs might be compensated for if the camera can be used as a high throughput system for regular patient care. Usually, business cases for the acquisition of an extended FOV PET camera are based on the fact that more patients can be scanned, because of the shorter acquisition times [ 11 ]. Usually, the situation that scans may take longer as a result of a lower injected dose or longer waiting time after injection is not taken into account.…”
Section: Consequences Of New Extended Fov Features For Application Of...mentioning
confidence: 99%
“…When imaging with an extended FOV PET-camera, an at least 8–10 times reduction of the injected dose is expected to produce equivalent or even better images than the current state-of-the-art PET scanners. This would correspond to making PET scanning available to healthy volunteers [ 11 , 12 ] – as long as the CT image is only necessary for attenuation correction. Another consequence of dose reduction is the possibility of imaging the same patient during more sessions, which leads to the use of PET more regularly as a tool for accurate therapy evaluation and planning.…”
Section: New Features Of Extended Field-of-view Pet Camerasmentioning
confidence: 99%
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“…Despite that whole-body dPET collected with either continuous bed motion or step-and-shoot multi-bed position provides a key measure to perform the precise diagnosis at locoregional area [16][17][18][19], the synchronized acquisition of temporal and spatial information is under expectation. With the advent of the total-body PET/CT scanner with a 194-cm long AFOV (uEXPLORER, United Imaging Healthcare, China), it is possible to collect both pathological and physiological information for the entire human body in one bed position [4,[20][21][22]. Additionally, the high PET sensitivity of the total-body scanner allows to generate time-activity curves (TACs) with ne structure.…”
Section: Introductionmentioning
confidence: 99%