Dynamic Pattern Formation of Microparticles in a Uniform Flow by an On-Chip Thermophoretic Separation Device

Tsuji, Tetsuro; Saita, Sho

doi:10.1103/physrevapplied.9.024035

Cited by 20 publications

(44 citation statements)

References 56 publications

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“…It is seen that |u r | increases in step with P. The flow fields obtained by numerical analysis using the commercial code COMSOL MULTIPHYSICS 5.2 (COMSOL, Inc., Stockholm, Sweden) are described in Fig. 3 [13,14], and the temperature gradient |∇T| = 0.5 K μm −1 [39]. Note that the actual value of D T is system specific but the order of magnitude is rather universal and within the above range [13].…”

Section: Flow Fieldsmentioning

confidence: 93%

“…The PDMS block is cast from a mold made from SU-8 photoresist with a fluid channel pattern. Details of the fabrication of the SU-8 mold are described in our previous study [39]. The PDMS block has two holes for the inlet and outlet, which are made with a biopsy punch (2.5 mm, BP-25F, Kai Industries Co., Ltd., Seki, Japan).…”

Section: B Microfluidic Devicementioning

confidence: 99%

“…Nonuniform temperature fields of aqueous solutions are produced by focusing the laser on the microchannel by the method described in Sec. II C. The temperature fields are measured using the laser-induced fluorescence (LIF) method [30,39,83]. A mixed solution of the fluorescent molecule 2 ,7 -bis-(2-carboxyethyl)-5-(6)carboxyfluorescein (BCECF) (Molecular Probes, Eugene, USA) and tris(hydroxymethyl)amino methane hydrochloride (tris-HCl) (pH = 8.0, Nippon Gene, Tokyo, Japan) is used as the temperature-sensitive sample.…”

Section: Temperature Fieldsmentioning

confidence: 99%

“…[13][14][15]. Thermophoresis has been investigated to manipulate biomolecules [16][17][18][19][20][21][22] and cells [23], as well as colloids for more fundamental investigations [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. It can also be applied to the concentration of DNA [41] or the measurement of protein binding [42,43].…”

Section: Introductionmentioning

confidence: 99%

“…Given such a growing interest in thermophoretic manipulation, some fundamental characterizations of thermophoresis near the contraction channels are necessary for further improvement of the manipulation technique. This study aims to carry out a systematic characterization of thermophoresis for translocating micro-and nanoparticles through contractions based on our previous study of thermophoresis in a microchannel [39]. We use a nearinfrared laser focused on the entrance of the contraction channel to heat the solution locally.…”

Section: Introductionmentioning

confidence: 99%

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Thermophoretic Manipulation of Micro- and Nanoparticle Flow through a Sudden Contraction in a Microchannel with Near-Infrared Laser Irradiation

Tsuji

Sasai

2018

Phys. Rev. Applied

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A temperature gradient in a continuous fluid induces the motion of dispersed micro-and nanoparticles even when the fluid is motionless. This phenomenon is known as thermophoresis, and it is expected to be the basis for techniques to control particle motion. In this study, we use the thermophoresis of microand nanoparticles in a microchannel filled with an aqueous solution to control the particle motion near the inlet of a sudden contraction, which is a narrower channel connecting two wider channels. Microfluidic devices with sudden contractions are widely used to develop various devices with micro-and nanometer dimensions, such as nanopore sensors. A near-infrared laser is used to create a strong temperature gradient of O(10 6) K m −1 and induce thermophoresis of micro-and nanoparticles. Because the heating by the laser irradiation is localized near the inlet of the contraction, this configuration is useful for controlling particle translocation into and through the contraction. We characterize our experimental setup by quantifying flow and temperature fields near the contraction channel using particle image velocimetry and laser-induced fluorescence, respectively. Then, we observe the obstruction of the particle translocation into the contraction channel induced by the laser-induced thermophoresis for various parameters such as channel dimensions, flow speeds, particle sizes, and laser powers. Near the inlet of the contraction channel, the counterbalance of thermophoretic force and flow drag leads to the ringlike pattern formation of the particle distribution. Moreover, we carry out some demonstrations using the proposed system to selectively translocate particles and enhance the sensing performance due to increased particle density. Thanks to the noncontact nature of laser-induced thermophoresis, the integration of our method into existing microfluidic devices is feasible and expected to improve technologies for manipulating particles in fluids.

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Section: Flow Fieldsmentioning

confidence: 93%

Section: B Microfluidic Devicementioning

confidence: 99%

Section: Temperature Fieldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Thermophoretic Manipulation of Micro- and Nanoparticle Flow through a Sudden Contraction in a Microchannel with Near-Infrared Laser Irradiation

Tsuji

Sasai

2018

Phys. Rev. Applied

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Switching between laser‐induced thermophoresis and thermal convection of liquid suspension in a microgap with variable dimension

2021

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Phoretic motion of particles along a temperature gradient formed in a fluid, known as thermophoresis, often takes place under the influence of bulk motion caused by thermal convection. In this paper, using a laser heating method, the significance of two competing effects, that is, thermophoresis and thermal convection, for the particle transport in a liquid phase confined in a microgap is investigated experimentally by changing the gap size as a control parameter. It is found that there is a threshold of the gap size, above which the particles tend to accumulate around the heated spot, forming a ring‐like particle distribution. On the contrary, if the gap size is below the threshold, the particles are depleted from the heated spot. Switching between these accumulation and depletion modes is expected to develop novel manipulation techniques.

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Thermoplasmonic Manipulation for the Study of Single Polymers and Protein Aggregates

Simon

Thalheim

Cichos

et al. 2023

Macro Chemistry & Physics

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Heat generation by means of plasmonic structures, which is at the heart of thermoplasmonics, has stimulated intense research on the manipulation of matter in liquid environments. Tiny noble metal structures with dimensions of a few tens of nanometers thereby serve as heat sources generating large temperature gradients. As a result, thermophoretic drifts occur, concentration fields form, or charge separation takes place. But also hydrodynamic boundary flows, which play an important role in microfluidic environments, can be induced. These processes remotely triggered by optically generated local dynamic temperature fields offer novel possibilities for manipulating and studying not only colloids but in particular also single molecules and their aggregates in solution.

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Dynamic Pattern Formation of Microparticles in a Uniform Flow by an On-Chip Thermophoretic Separation Device

Cited by 20 publications

References 56 publications

Thermophoretic Manipulation of Micro- and Nanoparticle Flow through a Sudden Contraction in a Microchannel with Near-Infrared Laser Irradiation

Thermophoretic Manipulation of Micro- and Nanoparticle Flow through a Sudden Contraction in a Microchannel with Near-Infrared Laser Irradiation

Switching between laser‐induced thermophoresis and thermal convection of liquid suspension in a microgap with variable dimension

Thermoplasmonic Manipulation for the Study of Single Polymers and Protein Aggregates

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