Dynamic optical coherence tomography of histamine induced wheals

Olsen, Jørgen; Birch-Johansen, F. H.; Themstrup, Lotte; Holmes, Jon; Jemec, Gregor B. E.

doi:10.1111/srt.12470

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Dynamic information was added by analyzing rapidly repeating OCT scans of identical frames to detect regions of movement as an arbitrary measure of blood flow. The measure of blood flow was indicated as percent motion within the same frame and calculated using the VivoSight DX integrated software tool (Michelson Diagnostics) [13,14]. Measurements of vessel width and depth were performed at the most evident level at en face images and verified by a blinded observer (P.L.A.).…”

Section: Methodsmentioning

confidence: 99%

“…It has previously been demonstrated that OCT can visualize cross‐sections of telangiectasia before and after IPL treatment [12]. Dynamic OCT (D‐OCT) adds detection of movement of red blood cells, allowing detection of blood flow levels as well as identification and measurement of superficial cutaneous blood vessels in both cross‐sectional and en face scans with great certainty [13,14]. Therefore, the aim of this study was to investigate whether D‐OCT could be utilized to characterize blood flow and vessel dimensions of facial telangiectasia before and after IPL treatment.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?

et al. 2020

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Background and Objectives To investigate whether optical coherence tomography (OCT) could be utilized to characterize blood flow and vessel dimensions of facial telangiectasias before and during consecutive intense pulsed light (IPL) treatment. Study Design/Materials and methods Dynamic OCT (D‐OCT) was used to image telangiectasia immediately before and after, 1–3 days after, and 1 month after IPL treatment. Measurements included vessel width and depth, blood flow, and attenuation. Vessel dimensions at baseline were verified by a blinded observer. Clinical improvement was detected as good, moderate, or none, and adverse effects were registered at 1‐month follow‐up. Results In total, 14 patients with facial telangiectasia were included. At baseline, vessel width was median 0.25 mm (interquartile range [IQR]: 0.19–0.34 mm) with an intra‐class coefficient (ICC) of 0.89 (95% confidence interval [CI]: 0.70; 0.97). Vessel depth was 0.30 mm (IQR: 0.25–0.33 mm; ICC: 0.40 [CI: −0.07; 0.75]). Vessel depth increased significantly from baseline to 1‐month follow‐up (P = 0.008), whereas no significant changes in vessel width, blood flow, or attenuation were detected. Clinical efficacy seemed related to the relation between vessel dimensions and applied energy settings. Conclusions The D‐OCT imaging technique demonstrated that facial telangiectasias were found deeper within the skin after one IPL treatment. By characterizing the vessel dimensions and blood flow of telangiectasia, D‐OCT may improve efficacy and safety of IPL. Lasers Surg. Med. © 2020 Wiley Periodicals LLC

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?

et al. 2020

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“…Any local movement, such as that produced by cutaneous capillary blood flow, is quantified by a dynamic OCT signal. By calculating the signal intensity of speckle variance across at frames at different depths, the software indirectly measured cutaneous capillary blood flow beneath the ACD and control reaction sites …”

Section: Methodsmentioning

confidence: 99%

“…By calculating the signal intensity of speckle variance across at frames at different depths, the software indirectly measured cutaneous capillary blood flow beneath the ACD and control reaction sites. 12…”

Section: Quantitative Dynamic Oct Scan Analysismentioning

confidence: 99%

Evaluation of positive patch test reactions using optical coherence tomography: A pilot study

Rajabi‐Estarabadi

Tsang

Nouri

et al. 2019

Skin Research and Technology

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Introduction Patch testing is the gold standard for evaluating allergic contact dermatitis (ACD), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (OCT) imaging enables noninvasive in vivo skin visualization and holds promise as an objective method of patch test interpretation. Objective To evaluate the micromorphological changes of patch test reactions and identify objective, quantitative OCT markers that correlate with clinically graded patch test reactions. Results A total of 25 patch test reactions (7 grade‐0, 4 grade‐1+, 14 grade‐2+) from 7 patients underwent OCT evaluation. Increased epidermal thickness and density was qualitatively observed in grade 1+ and grade 2+ allergic reactions while well‐demarcated, signal‐free cavities were observed in all grade 2+ reactions. Attenuation coefficients significantly increased across the three reaction grades (2.58 ± 0.092, 2.96 ± 0.121, 3.05 ± 0.065; P < 0.01). Cutaneous blood flow at 0.35 mm monotonically increased with reaction grade severity and blood measurements significantly differed across the three reaction grades (0.053 ± 0.011 mm/s, 0.078 ± 0.015 mm/s, and 0.121 ± 0.008 mm/s; P < 0.01). Conclusions and Relevance Attenuation coefficient and cutaneous blood flow at 0.35 mm correlate with clinically graded patch test reactions and hold promise as objective, quantitative markers. OCT may help dermatologists differentiate clinical scoring of allergic reactions in patch test and thereby improve their diagnostic accuracy and interpretation of patch test reactions.

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“…4.3 on oncology. 15,64 Additionally, Olsen et al 75 used OCT attenuation as a surrogate measure of skin edema, reporting an increase of the attenuation coefficient in edema of 10 subjects (median μ OCT increased from 1.8 mm −1 at baseline to 2.3 mm −1 ).…”

Section: Skin: Dermatological Conditions and Burnsmentioning

confidence: 99%

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

et al. 2020

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Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. Aim: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. Results: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. Conclusions: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.

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Dynamic optical coherence tomography of histamine induced wheals

Abstract: Dynamic optical coherence tomography is able to reliably identify changes in blood flow of histamine induced wheals. Dermal oedema reduces visualization depth and increases the attenuation coefficient.

Cited by 8 publications

References 26 publications

Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?

Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?

Evaluation of positive patch test reactions using optical coherence tomography: A pilot study

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

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