Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea<i>in vivo</i>

Li, Jiasong; Wang, Shang; Manapuram, Ravi Kiran; Singh, Manmohan; Menodiado, Floredes M.; Aglyamov, Salavat R.; Emelianov, Stanislav; Twa, Michael D.; Larin, Kirill V.

doi:10.1117/1.jbo.18.12.121503

Cited by 68 publications

(67 citation statements)

References 39 publications

(46 reference statements)

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“…3(b)) was somewhat similar to the displacements detected by the OCE system in this work ( Fig. 3(a)) and previous work [23,40]. The differences in the shape of the temporal profiles can be attributed to the different ways of each technique measure the J of Biomedical Photonics & Eng 1 (4) 1 Feb 2016 © SSAU 234 Fig.…”

Section: Discussionsupporting

confidence: 68%

“…1. Further details about the PhS-SSOCT system can be found in our previous work [39,40]. Briefly, the PhS-SSOCT system utilized a broadband swept laser source (HSL2000, Santec, Inc., Torrance, California) with central wavelength of 1310 nm, bandwidth of ~130 µm, scan rate of 30 kHz, and output power of ~39 mW.…”

Section: Methodsmentioning

confidence: 99%

“…The elastic wave velocity, c, was then obtained by the inverse slope of the linear fit of the propagation distances, Δd, to the elastic wave propagation delays, Δt [42]. Since the tissue-mimicking agar phantoms can be treated as an isotropic homogeneous elastic material, the Young's modulus [43], E, was estimated by [23,40,44]:…”

Section: J Of Biomedical Photonics and Eng 1(4)mentioning

confidence: 99%

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Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Liu

Schill

et al. 2015

JBPE

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Abstract. Purpose: Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young's modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods: The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results: The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial mechanical compression testing. Conclusion: The laser Michelson interferometric vibrometer is significantly more cost-effective, but it cannot directly provide the elastic wave temporal profile, nor can it offer in-depth information.

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Section: Discussionsupporting

confidence: 68%

Section: Methodsmentioning

confidence: 99%

Section: J Of Biomedical Photonics and Eng 1(4)mentioning

confidence: 99%

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Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Liu

Schill

et al. 2015

JBPE

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“…Point dynamic loading is attractive as a source of shear waves, and an attractive noncontact localized method is the micro-air puff developed and applied extensively by the Larin group [45, 57, 63, 81, [97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116], mainly to the cornea, but also to skin [108,116], cardiac and skeletal muscles [104], cartilage [101,106], fat and soft tissue tumors [97], and kidneys [112]. Similar to ARF-based excitation, an air puff can deliver a localized and well-controlled impulse stimulus, which can be accompanied by measurement of the tissue displacement or measurement of the air puff-induced elastic wave.…”

Section: Loading Methodsmentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

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258

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Abstract:Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography -the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published in 2015, and more than 25 in 2016, OCE is growing fast, but still small compared to the companion fields of cell mechanics research methods, and medical elastography. In this review, we describe the early developments in OCE, and the factors that led to the current acceleration. Much of our attention is on the key recent advances, with a strong emphasis on future prospects, which are exceptionally bright.

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“…This device is an adaptation to the noncontact tonometer (NCT) to measure the viscoelastic properties of the eye [6]. Lastly, another method uses a focused airpulse system and a phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves [7].…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

Razani

Luk

Mariampillai

et al. 2014

Biomed. Opt. Express

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Abstract:In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a sweptsource optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, synchronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were composed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in gel. Differential OCT phase maps, measured with and without the ARF, detected the microscopic displacement generated by shear wave propagation in these phantoms and samples of different stiffness. We present the technique for calculating tissue mechanical properties by propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. This method lays the foundation for future in-vitro and in-vivo studies of mechanical property measurements of biological tissues such as vascular tissues, where normal and pathological structures may exhibit significant contrast in the shear modulus.

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Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse corneain vivo

Cited by 68 publications

References 39 publications

Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

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