Dynamic of plasma IL-22 level is an indicator of thymic output after allogeneic hematopoietic cell transplantation

Shang, Longmei; Duah, Maxwell; Xu, Yan; Liang, Yiqing; Wang, Dong; Xia, Fan; Sun, Zengtian; Zhang, Yan; Xu, Kailin; Pan, Bin

doi:10.1016/j.lfs.2020.118849

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…In addition, recombinant IL22 administration enhanced thymus regeneration following damage in WT mice ( Dudakov et al, 2012 ), while increased IL22 levels were observed after damage ( Dudakov et al, 2012 ; Pan et al, 2014 ). Thus, thymus regeneration is IL22 dependent, and damage provokes increased availability of this key cytokine, the latter also being reported in the context of HSCT in man ( Shang et al, 2021 ). Subsequent studies also demonstrated the importance of IL22 for thymus function in models of Graft versus Host Disease ( Dudakov et al, 2017 ; Pan et al, 2019a ).…”

Section: Thymic Epithelial Cells and Thymus Regenerationmentioning

confidence: 74%

Generation and repair of thymic epithelial cells

Anderson,

Cosway,

James

et al. 2024

Journal of Experimental Medicine

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In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.

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Section: Thymic Epithelial Cells and Thymus Regenerationmentioning

confidence: 74%

Generation and repair of thymic epithelial cells

Anderson,

Cosway,

James

et al. 2024

Journal of Experimental Medicine

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“…IL-22 increases the number of TEC via a stat3-dependent signalling (91). More recently, it was shown that, after allogeneic hematopoietic transplantation, plasma IL-22 levels positively correlated with blood TREC levels (92).…”

Section: Il-22mentioning

confidence: 99%

End-Stage Renal Disease-Related Accelerated Immune Senescence: Is Rejuvenation of the Immune System a Therapeutic Goal?

et al. 2021

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End-stage renal disease (ESRD) patients exhibit clinical features of premature ageing, including frailty, cardiovascular disease, and muscle wasting. Accelerated ageing also concerns the immune system. Patients with ESRD have both immune senescence and chronic inflammation that are resumed in the so-called inflammaging syndrome. Immune senescence is particularly characterised by premature loss of thymic function that is associated with hyporesponsiveness to vaccines, susceptibility to infections, and death. ESRD-related chronic inflammation has multiple causes and participates to accelerated cardiovascular disease. Although, both characterisation of immune senescence and its consequences are relatively well-known, mechanisms are more uncertain. However, prevention of immune senescence/inflammation or/and rejuvenation of the immune system are major goal to ameliorate clinical outcomes of ESRD patients.

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“…The study analyzed the dynamic change of plasma IL-22 level and assessed recovery of thymic output function by detecting T-cell receptor excision circles (TRECs) level. The findings suggested that the dynamics of plasma IL-22 levels correlate with the recovery of thymus function in human allotransplants ( 134 ). Evidence from these studies implicates that cross-talk between IL-22 and TECs is crucial to mediate T-cell immunity’s reconstitution after injury.…”

Section: Regeneration Strategies Of the Thymusmentioning

confidence: 99%

Thymus Degeneration and Regeneration

Duah

Shen

et al. 2021

Front. Immunol.

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The immune system’s ability to resist the invasion of foreign pathogens and the tolerance to self-antigens are primarily centered on the efficient functions of the various subsets of T lymphocytes. As the primary organ of thymopoiesis, the thymus performs a crucial role in generating a self-tolerant but diverse repertoire of T cell receptors and peripheral T cell pool, with the capacity to recognize a wide variety of antigens and for the surveillance of malignancies. However, cells in the thymus are fragile and sensitive to changes in the external environment and acute insults such as infections, chemo- and radiation-therapy, resulting in thymic injury and degeneration. Though the thymus has the capacity to self-regenerate, it is often insufficient to reconstitute an intact thymic function. Thymic dysfunction leads to an increased risk of opportunistic infections, tumor relapse, autoimmunity, and adverse clinical outcome. Thus, exploiting the mechanism of thymic regeneration would provide new therapeutic options for these settings. This review summarizes the thymus’s development, factors causing thymic injury, and the strategies for improving thymus regeneration.

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Dynamic of plasma IL-22 level is an indicator of thymic output after allogeneic hematopoietic cell transplantation

Cited by 6 publications

References 42 publications

Generation and repair of thymic epithelial cells

Generation and repair of thymic epithelial cells

End-Stage Renal Disease-Related Accelerated Immune Senescence: Is Rejuvenation of the Immune System a Therapeutic Goal?

Thymus Degeneration and Regeneration

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