1994
DOI: 10.1161/01.cir.89.5.2085
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Dynamic nature of the aortic regurgitant orifice area during diastole in patients with chronic aortic regurgitation.

Abstract: The effective regurgitant orifice area decreases during diastole in patients with chronic aortic regurgitation. This phenomenon should be considered when evaluating aortic regurgitant severity.

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Cited by 19 publications
(13 citation statements)
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“…Impaired forward stroke volume yields a decreased systolic pressure and a narrow pulse pressure. 12,13 Although there is some degree of compensation by a Frank-Starling mechanism, the ventricle is functioning on a steep pressure-volume curve because of the lack of chamber dilation. This contrasts with chronic regurgitation, in which end-diastolic pressures are relatively low, and the additional stroke volume manifests as an increased systolic pressure (Table 2).…”
Section: Aortic Valve Regurgitationmentioning
confidence: 99%
“…Impaired forward stroke volume yields a decreased systolic pressure and a narrow pulse pressure. 12,13 Although there is some degree of compensation by a Frank-Starling mechanism, the ventricle is functioning on a steep pressure-volume curve because of the lack of chamber dilation. This contrasts with chronic regurgitation, in which end-diastolic pressures are relatively low, and the additional stroke volume manifests as an increased systolic pressure (Table 2).…”
Section: Aortic Valve Regurgitationmentioning
confidence: 99%
“…9 Furthermore, aortic pressure dependence of the orifice area has also been demonstrated in an in vitro model, 10 and changes of orifice area during diastole were observed in patients with chronic aortic regurgitation. 15 These observations suggest that dynamic alteration of the orifice may be a mechanism whereby vasodilator treatment reduces regurgitant volume and left ventricular volume. This is plausible because it is difficult in practice to reduce diastolic blood pressure significantly in patients with chronic aortic regurgitation, as they already have low diastolic pressures.…”
Section: Discussionmentioning
confidence: 93%
“…16 However, we did not observe any relation between percentage change in aortic pressure and orifice area, which is consistent with a previous report in patients with chronic aortic regurgitation. 15 The apparent inconsistency of these findings probably reflects the differences between acute and chronic animal models. In chronic aortic regurgitation, left ventricular systolic function, left ventricular volume, and left ventricular and aortic compliance vary substantially in animal models, depending on the severity and duration of the aortic regurgitation.…”
Section: Discussionmentioning
confidence: 99%
“…In patients with 1. unsatisfactory ultrasound windows, 2. with equivocal findings, and 3. in cases with contradictory results (e. g. mild regurgitation and severe left ventricular dysfunction) MR may be considered as the method of choice for further evaluation [57]. By means of PC-MR flow measurements through the aortic root, anterograde and retrograde blood flow during the cardiac cycle is quantified and provides accurate measures of regurgitant volume and regurgitant fraction [10,19,38,52]. Walker et al…”
Section: Assessment Of Lesion Severitymentioning
confidence: 99%