Dynamic MRI contrast enhancement of renal cortex: A functional assessment of renovascular disease in patients with renal artery stenosis

Gandy, Stephen J.; Sudarshan, Thiru; Sheppard, Declan; Allan, Lynsay; McLeay, Trudy; Houston, J. Graeme

doi:10.1002/jmri.10381

Cited by 36 publications

(21 citation statements)

References 18 publications

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“…Magnetic resonance angiography (MRA) is currently capable of accurate depiction of the aorta in children [34], but, even in the main renal arteries, image quality is not always adequate. This may change as spatial and temporal resolution improves.…”

Section: Doppler Ultrasound Imaging Ct and Mrimentioning

confidence: 99%

Captopril-enhanced renal scintigraphy in the diagnosis of pediatric hypertension

et al. 2010

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Hypertension in childhood is no longer a rare condition mainly secondary to renal, or renovascular diseases, as a growing proportion of children are obese and hypertensive, with the phenotype of metabolic syndrome. Thus, we need to reconsider our practice in the examination of the hypertensive child and redefine the place of non-invasive methods for screening of renovascular hypertension, and specifically, to evaluate the value of captopril-enhanced renal scintigraphy at the two ends of the palette: the obese child with hypertension and the severely hypertensive prepubertal child. Renal artery stenosis in children is mainly due to fibromuscular dysplasia and stenoses associated with syndromes involving single or multiple smaller branch vessels. This explains the low specificity and sensitivity of the color-Doppler ultrasound method and captopril renal scintigraphy. Even the more sophisticated computed tomography (CT) and magnetic resonance imaging (MRI) angiographic techniques are, at present, not sensitive enough to exclude stenoses of the small branches definitely. Thus, children in whom there is a strong suggestion of renovascular hypertension should undergo angiography with a view to endovascular treatment, as non-invasive imaging has no significant benefit and might lead to a delay in treatment. In the cases when the probability of renovascular disease is moderate a basic assessment of renal function and structure is sufficient. In the neonate, catheter-associated thromboembolic disease is among the most common causes hypertension. It should be controlled medically until the patient is old enough to undergo angiography and angioplasty successfully. Thus, in this age group, there is a place for functional imaging with renal sonography and angiotensin-converting enzyme inhibitor (ACEI) renography to detect hemodynamically significant renovascular disease, with the limitations mentioned above. However, the rapid technical evolution of non-invasive methods requires periodic re-consideration of the actual standpoints.

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Section: Doppler Ultrasound Imaging Ct and Mrimentioning

confidence: 99%

Captopril-enhanced renal scintigraphy in the diagnosis of pediatric hypertension

et al. 2010

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“…The MR protocol is presented in Table 1. The dynamic sequence used ("VIBE": Volumetric Interpolated Breathhold Examination) [7] was acquired before and 12 times (at 1-min intervals) after contrast agent injection of a single dose (0.2 mmol/kg body weight) of Magnevist (Schering, Berlin, Germany) at 2 ml/s into an antecubital vein.…”

Section: Case Reportmentioning

confidence: 99%

Magnetic resonance imaging of autologous fat grafting

2005

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A 30-year-old female patient with isolated facial lipodystrophy underwent two sessions of fat injection. MR signals of injected fat at different injection ages were compared to native fat. Native T1 signal was smaller for transplant fat, probably due to a slightly lower fat content and/or fibrosis or due to higher perfusion. T2 signal of transplants was significantly higher than that of native fat. T1 post-contrast was also higher, and contrast uptake of transplanted fat increased slightly with transplant age, which could be explained by an increasing perfusion. This study demonstrates the differences and MR signal time changes of native and transplanted fat.

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“…In der Literatur werden zahlreiche Ansätze für Perfusionsbildgebung der Nieren präsentiert [9,22,42] …”

Section: Perfusionsbildgebungunclassified

“…Dies kann mit vermindertem makro-oder mikrovaskulären Blutfluss hinreichend erklärt werden. Daher kann postuliert werden, dass alle Erkrankungen der Nieren, die zu einer mikro-oder makrovaskulären Schädigung führen, letztlich pathologische Perfusionsparameter aufweisen werden [1,5,9,10,20,21,29,35,36].…”

Section: Klinische Anwendung Der Funktionellen Mr-parameterunclassified