Dynamic MR imaging of carpal tunnel syndrome

Brahme, S.K.; Hodler, Juerg; Braun, Richard M.; Sebrechts, Christopher; Jackson, William T.; Resnick, Donald

doi:10.1007/s002560050270

Cited by 33 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In most studies, the diagnosis of CTS was verified by means of pathological nerve conduction studies. The study of Brahme et al (8), in contrast, included only patients with normal nerve conduction studies. In three studies, the findings of the patients' nerve conduction studies were either pathological or normal.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies, with a total of 509 affected wrists in 373 patients with CTS, were left for final assessment (7,8,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). The number of referents was 407, 192 of whom were healthy volunteers (287 wrists in 9 of 13 studies), 42 of whom were the study patients (49 contralateral symptom-free wrists of patients in 2 of 13 studies), and 173 of whom were symptomatic referemce patients imaged for a wrist pathology other than CTS (173 wrists in 2 of 13 studies).…”

Section: Resultsmentioning

confidence: 99%

“…From 53% to 98% of patients with clinically diagnosed CTS have abnormalities in nerve conduction tests (7). Imaging techniques had minor importance in the assessment of CTS before the introduction of magnetic resonance imaging (MRI) (8).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Magnetic resonance imaging findings in respect to carpal tunnel syndrome

Pasternack¹,

Malmivaara²,

Tervahartiala³

et al. 2003

Scand J Work Environ Health

View full text Add to dashboard Cite

The objective of this systematic review was to examine the technical and diagnostic capability of magnetic resonance imaging (MRI) to identify carpal tunnel syndrome (CTS). Two independent authors retrieved and screened the existing data and extracted the clinical and validity data adhering to predefined inclusion criteria. The MRI methods and findings were analyzed by two experienced radiologists. Disagreements were solved in consensus. The MRI findings of 373 affected wrists in 13 studies were compared with asymptomatic referents or a series of patients with non-CTS wrist pain. Increased T2-signal, cross-sectional area, and flattening of the median nerve inside the carpal tunnel, as well as bowing of the flexor retinaculum, were the most frequently occurring signs in CTS. Reliable assessment of the sensitivity and specificity of certain MRI signs in respect to CTS remained difficult due to study heterogeneity. There is an obvious need for imaging studies in which validated diagnostic criteria are used.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging findings in respect to carpal tunnel syndrome

Pasternack¹,

Malmivaara²,

Tervahartiala³

et al. 2003

Scand J Work Environ Health

View full text Add to dashboard Cite

show abstract

“…Many authors have used to different visualization technics to demonstrate median nerve in carpal tunnel such as MRI (Kim et al;Deryani et al, 2003;Grant et al;Bone´l et al, 2001;Keberle et al, 2000;Monagle et al, 1999;Kleindienst et al, 1998;Amrami et al;Brahme et al, 1997;Allmann et al, 1997;Sugimoto et al, 1994;Andreisek et al), diffusion tensor imaging and tractography, and sonography with compare to MR and CT scans (Buchberger et al, 1992;Propeck et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Analysis of MR Imaging of Wrists in Female Patients with Carpal Tunnel Syndrome and Healthy Controls

Karabulut

Tuncer

Karabulut³

et al. 2009

Int. J. Morphol.

View full text Add to dashboard Cite

SUMMARY:The objective of this study was to evaluate morphological changes of the median nerve in patients with carpal tunnel syndrome (CTS) and healthy controls, to correlate the MRI findings of wrists. This study compared not only morphological changes of the median nerve and also displayed descriptively structures in carpal tunnel between patients diagnosed with idopathic CTS and healthy controls. Our study involved 60 hand, 30 of hand were evaluated diagnosed with idiopathic CTS and 30 hand as healthy controls bilaterally. Two provocative tests (Phalen's and Tinel's test) were performed on each hand for both the patient group (60 wrist) and the control group (60 wrist). With regard to Phalen and Tinel's test results, 24 and 26 wrists were excluded from patient and control groups respectively. Totally 70 wrists were evaluated, and in terms of cross-sectional area of median nerve at the level of distal radioulnar joint, pisiform bone and the hook of hamate bone by MRI in the patient and control groups. In addition to evaluation of crosssectional area of median nerve, we determined signal intensity of wrists and different localization of the median nerve in the carpal tunnel. Cross-sectional area of the median nerve measured by wrist magnetic resonance at the level of metacarpal bones and signal intensity of wrists may be considered as a valuable indicator to determine patients referred with idiopathic CTS.

show abstract

“…This hypothesis is supported by recent MRI studies that showed evidence of tenosynovial swelling. 5,6 A number of researchers attempted to identify pathological changes in idiopathic CTS. Most reported that inflammatory cells are rare and that edema and nonspecific fibrosis are the most common histological findings of tenosynovium.…”

mentioning

confidence: 99%

Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome

Kim

Koh

Kim

et al. 2010

Journal Orthopaedic Research

View full text Add to dashboard Cite

Ischemic-reperfusion injury is thought to be a cause of idiopathic carpal tunnel syndrome (CTS). The purpose of this study was to determine whether oxidative stress caused by ischemia-reperfusion injury in subsynovial connective tissue is associated with idiopathic CTS and its symptoms. Bioptic samples of tenosynovial tissue were collected from 20 idiopathic CTS patients during surgery. Control specimens of tenosynovial tissue were collected from eight non-CTS patients. Analysis included histological and immunohistochemical examination for the distribution of endothelial nitric oxide synthase (eNOS), nuclear factor (NF)-␤, and transforming growth factor (TGF)-␤ RI in subsynovial connective tissues. Histological examinations showed a marked increase in fibroblast density and vascular proliferation in specimens from CTS patients. The expressions of eNOS, NF-␤, and TGF-␤ RI in fibroblasts and vascular endothelial cells of subsynovial connective tissues of patients were significantly higher than in those of controls. A significant positive correlation was found between the subjective symptom severity of CTS, and the immunoreactivities of eNOS and NF-␤. This study suggests that oxidative stress in subsynovial connective tissue is related to CTS and its symptoms. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J. Orthop. Res. 28: 1463Res. 28: -1468Res. 28: , 2010 Keywords: idiopathic carpal tunnel syndrome; oxidative stress; subsynovial connective tissueThe disease mechanism of idiopathic carpal tunnel syndrome (CTS) involves an elevated carpal tunnel pressure due to a reduction in the size of the tunnel or an increase in the volume of its content. 1,2 Previous studies demonstrated that no significant differences exist between patients with and without CTS in terms of transverse carpal ligament, 3,4 and, therefore, suggested that CTS is likely caused by an increase in carpal tunnel volume. This hypothesis is supported by recent MRI studies that showed evidence of tenosynovial swelling. 5,6 A number of researchers attempted to identify pathological changes in idiopathic CTS. Most reported that inflammatory cells are rare and that edema and nonspecific fibrosis are the most common histological findings of tenosynovium. 7 However, some authors pointed out that these pathological findings do not well correlate with the symptoms of CTS. 2,8 Freeland et al. 9 suggested that ischemia-reperfusion injury is an important cause of idiopathic CTS. This injury type would increase the levels of several types of proinflammatory cytokines in tenosynovium, and possibly cause the pathologic changes observed in idiopathic CTS. The purpose of our study was to seek evidence of the oxidative stress caused by ischemia-reperfusion injury in subsynovial connective tissue of idiopathic CTS and to investigate the extent of the association between oxidative stress and the symptoms of idiopathic CTS. MATERIALS AND METHODSThis study was approved by our institutional review board, and informed consent for spec...

show abstract

Dynamic MR imaging of carpal tunnel syndrome

Cited by 33 publications

References 8 publications

Magnetic resonance imaging findings in respect to carpal tunnel syndrome

Magnetic resonance imaging findings in respect to carpal tunnel syndrome

Analysis of MR Imaging of Wrists in Female Patients with Carpal Tunnel Syndrome and Healthy Controls

Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome

Contact Info

Product

Resources

About