“…Proximity‐induced protein–protein interactions are key regulation events to enable robust switching of enzyme activity [4, 5] . The construction of synthetic platforms for protein assembly and enzyme activation provides entries to revealing the molecular mechanisms behind spatial organization in signalling pathways [6] and a compact set of diverse scaffolds have shown great promise, including synthetic materials, [7, 8] DNA origami, [9, 10] and protein scaffolds [11, 12] . Several proteins have been shown to be appropriate engineering scaffolds for assembling and activating enzymes, [6, 13, 14] but often harbor limitations with regard to possibilities for tuning of the affinities of the recruitment domains.…”