Dynamic micro-Hall detection of superparamagnetic beads in a microfluidic channel

Aledealat, Khaled; Mihajlović, Goran; Chen, K.; Field, Mark; Sullivan, Gerard; Xiong, Peng; Chase, P. Bryant; Molnár, S. von

doi:10.1016/j.jmmm.2010.08.006

Cited by 15 publications

(10 citation statements)

References 24 publications

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“…Recently, in-flow detection with magnetic sensors based on a cytometric format addressed the need for analyses on a cell level and promised high-throughput enumerations of magnetically labelled entities. [38][39][40][41][42][43][44] In addition, droplet-based microfluidics encapsulating biological species and magnetic nanoparticles can also benefit from the fast development of magnetic flow detection as emulsion droplets armed with magnetic functionality can be used to transport, mix and release cargos in a controlled manner. 25,26 The effective on-chip operation of emulsion droplets, however, relies on a clear identification of their volume and the concentration of encapsulated magnetic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

A highly flexible and compact magnetoresistive analytic device

et al. 2014

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A grand vision of realization of smart and compact multifunctional microfluidic devices for wearable health monitoring, environment sensing and point-of-care tests emerged with the fast development of flexible electronics. As a vital component towards this vision, magnetic functionality in flexible fluidics is still missing although demanded by the broad utility of magnetic nanoparticles in medicine and biology. Here, we demonstrate the first flexible microfluidic analytic device with integrated high-performance giant magnetoresistive (GMR) sensors. This device can be bent to a radius of 2 mm while still retaining its full performance. Various dimensions of magnetic emulsion droplets can be probed with high precision using a limit of detection of 0.5 pl, providing broad applicability in high-throughput droplet screening, flow cytometry and drug development. The flexible feature of this analytic device holds great promise in the realization of wearable, implantable multifunctional platforms for biomedical, pharmaceutical and chemical applications.

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Section: Introductionmentioning

confidence: 99%

A highly flexible and compact magnetoresistive analytic device

et al. 2014

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“…Indium arsenide forms an active layer in various optoelectronic devices, such as quantum cascade lasers or infrared detectors . Current application of InAs also includes Hall sensor devices and high‐electron‐mobility transistors (HEMTs) in which transport properties are extremely important. As a result, more and more detailed knowledge about this compound and its interfaces is still needed for the design of complex structures meant for applications.…”

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confidence: 99%

Locally‐Strain‐Induced Heavy‐Hole‐Band Splitting Observed in Mobility Spectrum of p‐Type InAs Grown on GaAs

Wróbel

Umana‐Membreno

Boguski

et al. 2020

Physica Rapid Research Ltrs

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High‐quality Be‐doped InAs layer grown by molecular beam epitaxy on GaAs substrate has been examined via magnetotransport measurements and high‐resolution quantitative mobility spectrum analysis (HR‐QMSA) in the range of 5–300 K and up to 15 T magnetic field. The results show four‐channel conductivity and essential splitting of the most populated hole‐like channel below 55 K. It is concluded that origin of such effect results from the locally strain‐induced interlayer, which direct observation is difficult or impossible via alternative techniques. Based on the magnetotransport data analysis, the multilayer model is proposed, which is implemented into nextnano simulation, giving the proof of the argumentation correctness. These results indicate potential usefulness of HR‐QMSA technique even in the degeneration statistic regime.

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“…The Hall voltage response ( Figure 3(b) ) and corresponding SEM image ( Figure 3(c) ) for the two-strand annealing event ( Figure 3(a) ) indicate a voltage of 0.34 ± 0.03 μ V (0 ± 0.04 μ V for control junction) for the two observed beads near the Hall junction. The two-dimensional (2D) theoretical Hall response has recently been modeled with respect to SPM bead position over the Hall junction [ 50 ]. The theoretical response for a single bead over the Hall junction in Figure 3 is shown in Figure 3(d) , where red indicates a SPM particle positioned at the center of the device, while blue is a SPM outside the detectable range of the Hall junction.…”

Section: Resultsmentioning

confidence: 99%

Detection of Target ssDNA Using a Microfabricated Hall Magnetometer with Correlated Optical Readout

Hira

Aledealat

Chen

et al. 2012

Journal of Biomedicine and Biotechnology

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Sensing biological agents at the genomic level, while enhancing the response time for biodetection over commonly used, optics-based techniques such as nucleic acid microarrays or enzyme-linked immunosorbent assays (ELISAs), is an important criterion for new biosensors. Here, we describe the successful detection of a 35-base, single-strand nucleic acid target by Hall-based magnetic transduction as a mimic for pathogenic DNA target detection. The detection platform has low background, large signal amplification following target binding and can discriminate a single, 350 nm superparamagnetic bead labeled with DNA. Detection of the target sequence was demonstrated at 364 pM (<2 target DNA strands per bead) target DNA in the presence of 36 μM nontarget (noncomplementary) DNA (<10 ppm target DNA) using optical microscopy detection on a GaAs Hall mimic. The use of Hall magnetometers as magnetic transduction biosensors holds promise for multiplexing applications that can greatly improve point-of-care (POC) diagnostics and subsequent medical care.

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Dynamic micro-Hall detection of superparamagnetic beads in a microfluidic channel

Cited by 15 publications

References 24 publications

A highly flexible and compact magnetoresistive analytic device

A highly flexible and compact magnetoresistive analytic device

Locally‐Strain‐Induced Heavy‐Hole‐Band Splitting Observed in Mobility Spectrum of p‐Type InAs Grown on GaAs

Detection of Target ssDNA Using a Microfabricated Hall Magnetometer with Correlated Optical Readout

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