Amyotrophic Lateral Sclerosis 2012
DOI: 10.5772/32384
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Dynamic Meta-Analysis as a Therapeutic Prediction Tool for Amyotrophic Lateral Sclerosis

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Cited by 5 publications
(8 citation statements)
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“…Asides from approaches using MINs, which have been the subject of this review, several studies have applied mathematical modelling to attempt to understand the pathology in terms of relationships between high-order disease concepts such as “genetic damage”, “necro-apoptosis”, “calcium homeostasis”, “cellular respiration”, and other processes [141,142], whereas others have mathematically modelled clinical features in order to better predict disease progression in each patient [143,144]. MIN approaches may ultimately feed into higher order and clinical models, for example if they are used to better define molecular pathways or molecular biomarkers.…”
Section: Discussionmentioning
confidence: 99%
“…Asides from approaches using MINs, which have been the subject of this review, several studies have applied mathematical modelling to attempt to understand the pathology in terms of relationships between high-order disease concepts such as “genetic damage”, “necro-apoptosis”, “calcium homeostasis”, “cellular respiration”, and other processes [141,142], whereas others have mathematically modelled clinical features in order to better predict disease progression in each patient [143,144]. MIN approaches may ultimately feed into higher order and clinical models, for example if they are used to better define molecular pathways or molecular biomarkers.…”
Section: Discussionmentioning
confidence: 99%
“…Ca2 + increases could come from a variety of mechanisms beyond direct or significant changes in neuromodulatory transmission. As proposed in prior work (Mitchell and Lee, 2012; Mitchell et al, 2015b; Hollinger et al, 2016; Kim et al, 2016), failed homeostasis in nearly ten different major pathways could explain how a variety of different perturbations that result in ALS and identified homeostatic regulatory instability. Ca2 + regulation is also greatly impacted by changes in energetic pathways (namely mitochondria and endoplasmic reticulum Ca2 + stores) and oxidative stress (Bond et al, 2018), and to a lesser degree, by apoptotic signaling (Irvin et al, 2015).…”
Section: Discussionmentioning
confidence: 82%
“…Thus, even small or seemingly insignificant oscillatory increases or decreases in neuromodulators, which could easily be rectified with compensatory regulation in normal cells, could potentially wreak havoc in ALS cells. In fact, as discussed in more detail in the Section Astrocyte GluR as a Potential Pre-onset ALS Treatment Target, motoneurons are mathematically and functionally more susceptible to such instability (Mitchell and Lee, 2012; Irvin et al, 2015). Other recent work has also illustrated that motoneuron microcircuits are more prone to homeostatic dysregulation (Brownstone and Lancelin, 2018).…”
Section: Discussionmentioning
confidence: 99%
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