In previous earthquakes, masonry structures, especially those masonry structures with prefabricated slab was damaged severely, and caused heavy casualty and property losses. In order to improve the seismic behavior of prefabricated slab, a new type of prefabricated slab with longitudinal and transverse joint steel bar was designed. By employing a numerical simulation procedure, LS-DYNY3D, models were established, and their seismic behaviors were analyzed .The results show that, the masonry structure of new type prefabricated slab with longitudinal and transverse joint steel bar is better than the structure with traditional prefabricated slab in structural integrity and stability. That is to say, its seismic behavior is better than the masonry structure with traditional prefabricated slab.