Introduction and Hypothesis
This study aims to assess the role of individual anatomical structures and their combinations to urethral support function.
Methods
A realistic pelvic model was developed from an asymptomatic female subject’s MR images for dynamic biomechanical analysis using the finite element method. Validation was performed by comparing simulation results with dynamic MR imaging observations. Weaknesses of anatomical support structures were simulated by reducing their material stiffness. Urethral mobility was quantified by examining the urethral axis excursion from rest to the final state (Intra-abdominal pressure = 100cmH2O). Seven individual support structures and five of their combinations were studied.
Result
Among seven urethral support structures, weakening the vaginal walls, puborectalis muscle and pubococcygeus muscle generated the top three largest urethral excursion angles. A linear relationship was found between urethral axis excursions and intra-abdominal pressure. Weakening all three levator ani components together caused a larger weakening effect than the sum of each individually weakened component, indicating a nonlinearly-additive pattern. The pelvic floor responded to different weakening conditions distinctly: weakening the vaginal wall developed urethral mobility through collapsed vaginal canal while weakening the levator ani showed a more uniform pelvic floor deformation.
Conclusions
The computational modeling and dynamic biomechanical analysis provides a powerful tool to better understand the dynamics of the female pelvis under pressure events. The vaginal walls, puborectalis and pubococcygeus are the most important individual structures in providing urethral support. The levator ani muscle group provides urethral support in a well-coordinated way with a nonlinearly-additive pattern.