Dynamic magnetic characterization and magnetic particle imaging enhancement of magnetic-gold core–shell nanoparticles

Tomitaka, Asahi; Ota, Satoshi; Nishimoto, Kizuku; Arami, Hamed; Takemura, Yasushi; Nair, Madhavan

doi:10.1039/c9nr00242a

Cited by 40 publications

(34 citation statements)

References 54 publications

(62 reference statements)

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“…For other metallic nanoparticle imaging concepts in development, for example core-shell formulations (Aouidat et al, 2019;Tomitaka et al, 2019;X. D. Wang, Li, & Chen, 2018), there are other challenges to consider.…”

Section: Physicochemical Characterizationmentioning

confidence: 99%

Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology

Crist

Dasa

Liu

et al. 2020

WIREs Nanomed Nanobiotechnol

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Despite imaging agents being some of the earliest nanomedicines in clinical use, the vast majority of current research and translational activities in the nanomedicine field involves therapeutics, while imaging agents are severely underrepresented. The reasons for this lack of representation are several fold, including difficulties in synthesis and scale‐up, biocompatibility issues, lack of suitable tissue/disease selective targeting ligands and receptors, and a high bar for regulatory approval. The recent focus on immunotherapies and personalized medicine, and development of nanoparticle constructs with better tissue distribution and selectivity, provide new opportunities for nanomedicine imaging agent development. This manuscript will provide an overview of trends in imaging nanomedicine characterization and biocompatibility, and new horizons for future development. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine

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Section: Physicochemical Characterizationmentioning

confidence: 99%

Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology

Crist

Dasa

Liu

et al. 2020

WIREs Nanomed Nanobiotechnol

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“…The peaks from MNPs corresponded to the inverse cubic spinel phase of Fe 3 O 4 , and MNP@Au nanostars showed sharp peaks contributed from gold shell as well as smaller peaks representing Fe 3 O 4 . We previously calculated the gold shell thickness of MNP@Au nanospheres by applying Scherrer's equation on the diffraction peaks 12 . Based on the crystallite size d given by…”

Section: Resultsmentioning

confidence: 99%

“…where λ is the X-ray wavelength, β is the full-width at half-maximum of the X-ray diffraction peak, and K is a constant related to crystallite shape (equals to 0.90) 37,38 , the gold shell thickness was estimated to be 8.2 nm 12 . This small shell thickness compared to the particle size of MNP@Au nanospheres (33.0 nm) demonstrates that the gold shell was formed on MNPs core.…”

Section: Resultsmentioning

confidence: 99%

“…This magnetic force can be used to manipulate magnetic nanoparticles and enhance targeting efficiencies for drug delivery applications 10,11 . In contrast, magnetic nanoparticles behave differently under alternating magnetic field conditions 12 . Magnetic relaxation occurs in the presence of an alternating magnetic field and this unique response has been applied for magnetic particle imaging (MPI) 13,14 and magnetic hyperthermia, which is a thermal treatment for cancer using heat generation from magnetic nanoparticles 15,16 .…”

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confidence: 99%

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Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery

Tomitaka

Arami

Ahmadivand

et al. 2020

Sci Rep

Self Cite

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Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.

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“…They used the magnetic nanoparticle as core material while the gold nanoparticle as the outer shell and established their theranostic application. 85 Additionally, Zhao et al (2019) utilized modified gold nanoparticle as novel SPECT (Single Photon Emission Computed Tomography) imaging tool and radionuclides therapy of glioma. They synthesized polyethyleneimine loaded chlorotoxin peptide and PEGmodified gold nanoparticle.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

<p>Recent expansions of novel strategies towards the drug targeting into the brain</p>

Alexander¹,

Agrawal²,

Uddin³

et al. 2019

IJN

117

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The treatment of central nervous system (CNS) disorders always remains a challenge for the researchers. The presence of various physiological barriers, primarily the blood–brain barrier (BBB) limits the accessibility of the brain and hinders the efficacy of various drug therapies. Hence, drug targeting to the brain, particularly to the diseased cells by circumventing the physiological barriers is essential to develop a promising therapy for the treatment of brain disorders. Presently, the investigations emphasize the role of different nanocarrier systems or surface modified target specific novel carrier system to improve the efficiency and reduce the side effects of the brain therapeutics. Such approaches supposed to circumvent the BBB or have the ability to cross the barrier function and thus increases the drug concentration in the brain. Although the efficacy of novel carrier system depends upon various physiological factors like active efflux transport, protein corona of the brain, stability, and toxicity of the nanocarrier, physicochemical properties, patient-related factors and many more. Hence, to develop a promising carrier system, it is essential to understand the physiology of the brain and BBB and also the other associated factors. Along with this, some alternative route like direct nose-to-brain drug delivery can also offer a better means to access the brain without exposure of the BBB. In this review, we have discussed the role of various physiological barriers including the BBB and blood-cerebrospinal fluid barrier (BCSFB) on the drug therapy and the mechanism of drug transport across the BBB. Further, we discussed different novel strategies for brain targeting of drug including, polymeric nanoparticles, lipidic nanoparticles, inorganic nanoparticles, liposomes, nanogels, nanoemulsions, dendrimers, quantum dots, etc. along with the intranasal drug delivery to the brain. We have also illustrated various factors affecting the drug targeting efficiency of the developed novel carrier system.

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Dynamic magnetic characterization and magnetic particle imaging enhancement of magnetic-gold core–shell nanoparticles

Abstract: The gold coating on magnetic core nanoparticles enhanced magnetic particle imaging performance due to an alteration in dynamic magnetic responses.

Cited by 40 publications

References 54 publications

Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology

Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology

Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery

<p>Recent expansions of novel strategies towards the drug targeting into the brain</p>

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