Dynamic local mRNA localization and translation occurs during the postnatal molecular maturation of perivascular astrocytic processes
Katia Avila‐Gutierrez,
Leila Slaoui,
Rodrigo Alvear‐Perez
et al.
Abstract:Astrocytes are highly ramified and send out perivascular processes (PvAPs) that entirely sheathe the brain's blood vessels. PvAPs are equipped with an enriched molecular repertoire that sustains astrocytic regulatory functions at the vascular interface. In the mouse, PvAP development starts after birth and is essentially complete by postnatal day (P) 15. Progressive molecular maturation also occurs over this period, with the acquisition of proteins enriched in PvAPs. The mechanisms controlling the development … Show more
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