Dynamic Kinetic Resolution: An Efficient Route to anti α‐Amino‐β‐hydroxy Esters via Ru‐SYNPHOS® Catalyzed Hydrogenation.

Abstract

Hydroxycarboxylic acids (ether carboxylic acids) and esters P 0280Dynamic Kinetic Resolution: An Efficient Route to anti α-Amino-β-hydroxy Esters via Ru-SYNPHOS® Catalyzed Hydrogenation. -The Ru-catalyzed hydrogenation of α-amino-β-keto-esters as their hydrochloride salts (I) and (IV) affords the corresponding anti α-amino-β-hydroxy esters (III) and (V), respectively, under mild conditions with high diastereo-and enantioselectivities via dynamic kinetic resolution.-(MORDANT, C.; DUENKELMANN, P.; RATOVELOMANANA-VIDAL*, V.; GENET, J.-P.; Chem.

Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds

“…Methyl 3-oxooctanoate (16) (Balducci et al 2011;Mordant et al 2004 General procedure for deprotection of benzyl esters The benzyl ester was dissolved in MeOH, and a catalytic amount of 10 % Pd/C was added. The apparatus was evacuated and flushed with H 2 .…”

Methods for the Chemical Synthesis of Noncoded α‐Amino Acids found in Natural Product Peptides

“…In addition, b-hydroxy-a-amino acids are used as chiral building blocks in preparing precursors to important molecules [132][133][134][135][136][137]. Currently, various synthetic methods have been developed to prepare b-hydroxy-a- amino acids stereoselectively, which include asymmetric aldol reaction [138][139][140][141][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156], alkylation [153][154][155][156], electrophilic amination and allylic amination [157,158], conjugate addition [159], cyanation [160], enantioselective hydrogenation [161], selective hydrolysis [135], rearrangement [162][163][164][165], regioselective aziridine ring opening [135,[166][167][168], dynamic kinetic resolution (DKR) [169][170]…”