Dynamic kinetic asymmetric transformation of 1,4-diols and the preparation of trans-2,5-disubstituted pyrrolidines

Dynamic Kinetic Resolution via Hydrolase‐Metal Combo Catalysis in Stereoselective Synthesis of Bioactive Compounds

“…have recently described the DYKAT process of a series of aliphatic 1,4‐diols, catalyzed by CALB and ruthenium catalyst 10 . Through these reaction conditions, the corresponding optically active diacetates were formed, and subsequently employed in the synthesis of enantiopure 2,5‐disubstituted pyrrolidines (Scheme ) 35a…”

Stereoselective Enzymatic Reduction of 1,4-Diaryl-1,4-Diones to the Corresponding Diols Employing Alcohol Dehydrogenases

“…Among the wide set of (poly)alcohol structures that can be obtained using biocatalysts, the production of optically active 1,4-dialkyl-1,4-diols and their corresponding acetates has been described mainly by the action of lipases through resolution procedures involving acylation and transesterification processes [18][19][20][21][22][23][24][25], and only the resolution of the bulkier 1-phenylpentane-1,4-diol or its acetate has been successfully achieved [26,27]. Alcohol dehydrogenases (ADHs) are valuable biocatalysts that have been widely employed for the synthesis of chiral alcohols due to their usually excellent selectivity [28][29][30][31], including dicarbonyl bioreduction processes [32,33].…”

A Chemoenzymatic Dynamic Kinetic Resolution Approach to Enantiomerically Pure (R)- and (S)-Duloxetine

“…In a chemoenzymatic DKR an enzyme is employed as catalyst for the resolution while, e.g., a transition metal catalyst is employed for the racemization. Our group has successfully applied the concept of DKR to several substrate classes such as secondary alcohols, amines, diols, amino alcohols, and β-hydroxynitriles …”