Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics

BharathwajChetty, Bandari; Sajeev, Anjana; Vishwa, Ravichandran; Aswani, Babu Santha; Alqahtani, Mohammed S.; Abbas, Mohamed; Kunnumakkara, Ajaikumar B.

doi:10.1007/s10555-024-10171-0

Cited by 3 publications

(1 citation statement)

References 299 publications

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“…Clear lines of evidence have emerged elucidating the role of NRs in various pathologies, including asthma, diabetes, rheumatoid arthritis, and different cancers, including OVC ( 32 – 36 ). Multiple studies have proved the role of NRs in regulating significant hallmarks of cancer, such as proliferation, survival, epithelial-mesenchymal transition (EMT), invasion, migration, apoptosis, etc ( 37 – 44 ).…”

Section: Introductionmentioning

confidence: 99%

Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics

Sajeev,

BharathwajChetty,

Manickasamy

et al. 2024

Front. Oncol.

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Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in women worldwide. Despite advancements in detection and therapy, the prognosis of OVC remains poor due to late diagnosis and the lack of effective therapeutic options at advanced stages. Therefore, a better understanding of the biology underlying OVC is essential for the development of effective strategies for early detection and targeted therapies. Nuclear receptors (NRs) are a superfamily of 48 transcription factors that, upon binding to their specific ligand, play a vital role in regulating various cellular processes such as growth, development, metabolism, and homeostasis. Accumulating evidence from several studies has shown that their aberrant expression is associated with multiple human diseases. Numerous NRs have shown significant effects in the development of various cancers, including OVC. This review summarizes the recent findings on the role of NRs in OVC, as well as their potential as prognostic and therapeutic markers. Further, the basic structure and signaling mechanism of NRs have also been discussed briefly. Moreover, this review highlights their cellular and molecular mechanisms in chemoresistance and chemosensitization. Further, the clinical trials targeting NRs for the treatment of OVC have also been discussed.

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Section: Introductionmentioning

confidence: 99%

Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics

Sajeev,

BharathwajChetty,

Manickasamy

et al. 2024

Front. Oncol.

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Antheraxanthin: Insights delving from biosynthesis to processing effects

Zhao,

Chen,

Jiang

et al. 2024

Food Research International

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Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

Aswani,

Hegde,

Vishwa

et al. 2024

Military Med Res

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Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis of body. NRs have garnered increased attention due to their potential as therapeutic targets, with drugs directed at NRs demonstrating significant efficacy in impeding chronic disease progression. Consequently, these pharmacological agents hold promise for the treatment and management of various diseases. Accumulating evidence emphasizes the regulatory role of exosome-derived microRNAs (miRNAs) in chronic inflammation, disease progression, and therapy resistance, primarily by modulating transcription factors, particularly NRs. By exploiting inflammatory pathways such as protein kinase B (Akt)/mammalian target of rapamycin (mTOR), nuclear factor kappa-B (NF-κB), signal transducer and activator of transcription 3 (STAT3), and Wnt/β-catenin signaling, exosomes and NRs play a pivotal role in the panorama of development, physiology, and pathology. The internalization of exosomes modulates NRs and initiates diverse autocrine or paracrine signaling cascades, influencing various processes in recipient cells such as survival, proliferation, differentiation, metabolism, and cellular defense mechanisms. This comprehensive review meticulously examines the involvement of exosome-mediated NR regulation in the pathogenesis of chronic ailments, including atherosclerosis, cancer, diabetes, liver diseases, and respiratory conditions. Additionally, it elucidates the molecular intricacies of exosome-mediated communication between host and recipient cells via NRs, leading to immunomodulation. Furthermore, it outlines the implications of exosome-modulated NR pathways in the prophylaxis of chronic inflammation, delineates current limitations, and provides insights into future perspectives. This review also presents existing evidence on the role of exosomes and their components in the emergence of therapeutic resistance.

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Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics

Cited by 3 publications

References 299 publications

Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics

Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics

Antheraxanthin: Insights delving from biosynthesis to processing effects

Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

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