Dynamic interfacial tensiometry of biologic liquids — does it have an impact on medicine

Dynamic tensiometry studies on interactions of novel therapeutic inhalable powders with model pulmonary surfactant at the air–water interface

“…The surface active components of lung surfactant have very low CMCs and they adsorb at the interface, not as single molecules diffusing from the subsurface, but as vesicles that interact with the interface in a coalescence resembling process, with its own activation energy [41]. However, according to Kazakov et al [42] the asymptotic equations of adsorption kinetic theories can still be used to analyse dynamic tensiograms obtained for multi-component liquids, as they have been modified for extremely long surface lifetimes. In this case the asymptotic equations of adsorption kinetic theory need to be modified using the so-called Joos-Hansen equation [37,38,43].…”

“…Values of the derivative (d /dt −1/2 ) t→∞ for various biological liquids can be used to compare their adsorption characteristics, as for most surface active components the ratio i /c i in Eq. (2) is essentially constant and the sum in the right hand side of this equation is an approximation for the total adsorption of all constituents of a multi-component system with reference to their adsorption activity K i = i /c i [42]. When the data of a dynamic tensiogram are plotted in the co-ordinates versus t −1/2 a linear portion at t −1/2 → 0 can be derived.…”

“…According to the theory developed by Fainerman et al [37] is also a measure for the total equilibrium adsorption. The selection of parameters were done according to suggestions of Kazakov et al [42] with one modification -for the value of 2 the surface lifetime of 2 s not 1 s was chosen as it more precisely represents the characteristic timescale of changes of alveolar surface during the breathing cycle (i.e. the approximate time of inspiration or expiration phase).…”

Potentialities of Program Analysis of Probable Outcome in Patients with Acute Poisoning by Mushrooms

“…Будучи поверхностно активными веществами (ПАВ) [2] они способны адсорбироваться на жидких грани цах раздела фаз (жидкость -газ) и изменять по верхностное натяжение биологических жидкостей, ускорять или замедлять процессы переноса веще ства и энергии через биологические мембраны [3]. Динамическая тензиометрия и реометрия (изме рение поверхностного натяжения) БЖ человека получили наиболее широкое развитие за послед ние десять лет.…”

“…Динамическая тензиометрия и реометрия (изме рение поверхностного натяжения) БЖ человека получили наиболее широкое развитие за послед ние десять лет. Динамическая тензиометрия ПАВ позволяет получить важную информацию о соста ве, структуре и эволюции поверхностных слоев при различных заболеваниях [3]. Изменение пара метров межфазной тензиометрии БЖ имеет для практического врача ценность при оценке динами ки состоянии больного человека, а также при вы явления патологических состояний у практически здоровых людей.…”