Abstract:Translation initiation in eukaryotes requires multiple eukaryotic translation initiation factors (eIFs) and involves continuous remodeling of the ribosomal preinitiation complex (PIC). The GTPase eIF2 brings the initiator Met‐tRNAi to the PIC. Upon start codon selection and GTP hydrolysis promoted by its GTPase‐activating protein (GAP) eIF5, eIF2‐GDP is released in complex with eIF5. It is not known how eIF5 dissociates from its other binding partners to leave the PIC with only eIF2. Here, we report that two i… Show more
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