Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months

Bischoff, Adrianne Rahde; Pokhvisneva, Irina; Léger, Étienne; Gaudreau, Hélène; Steiner, Meir; Kennedy, James L.; O’Donnell, Kieran J.; Diorio, Josie; Meaney, Michael J.; Silveira, Patrícia Pelufo

doi:10.1371/journal.pone.0177344

Cited by 5 publications

(5 citation statements)

References 68 publications

(65 reference statements)

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“…In total, 89 samples from 60 studies including 52 822 children compared preterm and term-born children who had IUGR and were SGA with children with AGA with respect to cognitive outcomes. A total of 48 studies reported results for mean cognitive scores, and 24 studies reported the percentages of group-specific children with BII …”

Section: Resultsmentioning

confidence: 99%

Association of Intrauterine Growth Restriction and Small for Gestational Age Status With Childhood Cognitive Outcomes

et al. 2020

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The magnitude of the association of intrauterine growth restriction (IUGR) and small for gestational age (SGA) status with cognitive outcomes in preterm and term-born children has not been established.OBJECTIVE To examine cognitive outcomes of preterm and term-born children who had IUGR and were SGA compared with children who were appropriate for gestational age (AGA) during the first 12 years of life.DATA SOURCES For this systematic review and meta-analysis, the Scopus, PubMed, Web of Science, Science Direct, PsycInfo, and ERIC databases were searched for English-language, peer-reviewed literature published between January 1, 2000, and February 20, 2020. The following Medical Subject Heading terms for IUGR and SGA and cognitive outcomes were used: intrauterine growth restriction, intrauterine growth retardation, small for gestational age AND neurodevelopment, neurodevelopmental outcome, developmental outcomes, and cognitive development.STUDY SELECTION Inclusion criteria were assessment of cognitive outcomes (full-scale IQ or a cognitive subscale), inclusion of an AGA group as comparison group, and inclusion of gestational age at birth and completion of cognitive assessment up to 12 years of age. DATA EXTRACTION AND SYNTHESISThe Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guidelines were followed. Data were double screened for full-text articles, and a subset were independently coded by 2 authors. Standardized mean differences (SMDs) and odd ratios from individual studies were pooled by applying random-effects models. MAIN OUTCOMES AND MEASURESCognitive outcomes, defined as mental, cognitive, or IQ scores, estimated with standardized practitioner-based cognitive tests or as borderline intellectual impairment (BII), defined as mental, cognitive, or IQ scores at least 1 SD below the mean cognitive score. RESULTSIn this study of 89 samples from 60 studies including 52 822 children, children who had IUGR and were SGA had significantly poorer cognitive outcomes (eg, cognitive scores and BII) than children with AGA in childhood. For cognitive scores, associations are consistent for preterm (SMD, −0.27; 95% CI, −0.38 to −0.17) and term-born children (SMD, −0.39; 95% CI, −0.50 to −0.28), with higher effect sizes reported for term-born IUGR and AGA group comparisons (SMD, -0.58; 95% CI, -0.82 to -0.35). Analyses on BII revealed a significantly increased risk in the preterm children who had IUGR and were SGA (odds ratio, 1.57; 95% CI, 1.40-1.77) compared with the children with AGA.CONCLUSIONS AND RELEVANCE Growth vulnerabilities assessed antenatally (IUGR) and at the time of birth (SGA) are significantly associated with lower childhood cognitive outcomes in preterm and term-born children compared with children with AGA. These findings highlight the need to develop interventions that boost cognitive functions in these high-risk groups.

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Section: Resultsmentioning

confidence: 99%

Association of Intrauterine Growth Restriction and Small for Gestational Age Status With Childhood Cognitive Outcomes

et al. 2020

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“…In this study we have found some distinct patterns of association between the continuum of birth weight and childhood obesogenic behaviors considering linear and quadratic distributions and sex[53]. Birth weight effects were more evident in boys, as compared to girls, especially for physical activity and screen time.…”

Section: Discussionmentioning

confidence: 96%

Multi-behavioral obesogenic phenotypes among school-aged boys and girls along the birth weight continuum

et al. 2019

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Evidence shows that extremes of birth weight (BW) carry a common increased risk for the development of adiposity and related cardiovascular diseases, but little is known about the role of obesogenic behaviors in this process. Moreover, no one has empirically examined whether the relationship between BW, obesogenic behaviors and BMI along the full low-to-high birthweight continuum reflects the U-shape pattern expected from common risk at both BW extremes. Our objective was to characterize physical activity, screen time, and eating behavior and their relationship to BMI as a function of BW among school-aged boys and girls. In this cross-sectional study, 460 children aged 6 to 12 years (50% boys) from Montreal, Canada provided information on sleeping time, screen time, physical activity levels, eating behavior (emotional, external and restrained eating) and anthropometrics (height, weight, BW) through parent reported questionnaires. BMI was normalized using WHO Standards (zBMI), and BW expressed as ratio using Canadian population standards (BW for gestational age and sex). Analyses were conducted using generalized linear models with linear and quadratic terms for BW, stratified by sex and adjusted for age, ethnicity and household income. In boys, physical activity and screen time showed U-shaped associations with BW, while physical activity had an inverted U-shaped in girls. Emotional and restrained eating had positive linear relations with BW in boys and girls. Sleep time and external eating were not associated with BW. A U-shaped relationship between BW and zBMI was found in boys but no association was found in girls. Only sleep (in boys and girls), and emotional eating (girls only) were related to zBMI and mediation of the BW-zBMI relationship was only supported for emotional eating. In conclusion, BW relates to obesogenic behaviors and BMI in both non-linear and linear ways, and these associations differed by sex.

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“…For our secondary aim, a total of 68 articles were considered eligible and included in this systematic review after two-stage screening, as shown in Figure 1. Among the final included studies that assessed cognitive or academic outcomes, 11 studies (see Table S3) only investigated the effect of LGA, [35][36][37][38][39][40][41][42][43][44][45] 51 studies (see Table S2) only investigated the effect of early-term delivery (37 +0 w-38 +6 w), 13, 23-26, 29, 46-90 and 6 studies (see Table S1) explored the effects of both exposures simultaneously but independently. 28,30,[91][92][93][94] Early-term delivery…”

Section: Study Selectionmentioning

confidence: 99%

“…Furthermore, different definitions were utilized for LGA or full-term across studies. For example, although most studies used greater than the 90th percentile as the definition of LGA, several studies used the 80th 40 or 85th 35,42 percentile as the definition. Although most studies used the 10-90 th percentile as the definition of AGA, some studies used other reference groups, e.g.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Cognitive and academic outcomes of large-for-gestational-age babies born at early-term: a systematic review and meta-analysis

Wolke,

ZHAO,

POSKETT

et al. 2024

Preprint

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ABSTRACT(250 words)Background: Early induction of labour (38 -38 weeks) in large-for-gestational-age (LGA) babies may reduce risks such as shoulder dystocia but may increase another risk of reduced cognitive abilities in offspring. Objectives: To evaluate the cognitive and academic outcomes of LGA children born at early-term (combined exposures or independently) in the light of existing research. Search Strategy: 5 databases were searched from inception to March 2023 without language restrictions. Selection Criteria: Studies reporting on cognitive or academic outcomes either focusing on children born at early-term or LGA. Data Collection and Analysis: Besides narrative synthesis, we conducted meta-analyses where possible. Main Results: Out of 1592 identified articles, no study investigated the effect of early-term delivery in LGA babies on cognitive or academic outcomes. 68 articles investigated the cognitive effects of early-term delivery and LGA independently. Children born at 37 weeks (SMD, -0.13; 95% CI, -0.21 – -0.05) but not at 38 weeks (SMD, -0.04; 95% CI, -0.08 – 0.002) have lower cognitive scores than at 40 weeks. LGA children had slightly higher cognitive scores than AGA children (SMD, 0.06; 95% CI, 0.01 – 0.11). Syntheses results using cognitive impairment or academic performance as outcomes were similar. Conclusions: There is no existing study that investigated early-term delivery in LGA babies and their cognitive scores. Early-term delivery has a small detrimental effect on cognitive scores, whereas LGA may have a small benefit. Evidence from RCTs or observation studies is needed. Fundings: University of Warwick; UKRI (EP/X023206/1) Keywords: cognitive, intelligence, academic performance, early-term delivery, large-for-gestational-age, macrosomia, meta-analysis, systematic review

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Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months

Cited by 5 publications

References 68 publications

Association of Intrauterine Growth Restriction and Small for Gestational Age Status With Childhood Cognitive Outcomes

Association of Intrauterine Growth Restriction and Small for Gestational Age Status With Childhood Cognitive Outcomes

Multi-behavioral obesogenic phenotypes among school-aged boys and girls along the birth weight continuum

Cognitive and academic outcomes of large-for-gestational-age babies born at early-term: a systematic review and meta-analysis

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