Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement.

Heiken, Jay P.; Brink, James A.; McClennan, Bruce L.; Sagel, Stuart S.; Crowe, T M; Gaines, Mary V.

doi:10.1148/radiology.195.2.7724752

Cited by 278 publications

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“…CM injection protocols are determined by a combination of several factors, including CM volume (27)(28)(29)(30)(31), CM concentration, rate of injection, and type of injection (27,32). The rationale of any injection protocol is to deliver an adequate amount of CM in order to obtain optimal parenchymal and vascular enhancement.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is affected by the total volume of CM. It can be modulated on the basis of iodine concentration: The higher the iodine concentration, the lower the volume of injected CM (1,5,31). For example, to achieve optimal parenchymal enhancement of the liver (around 50-60 HU), it is necessary to deliver around 500-750 mgI per kg of body weight (1).…”

Section: Discussionmentioning

confidence: 99%

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Analysis of the Effects of Different Iodine Concentrations on the Characterization of Small Renal Lesions Detected by Multidetector Computed Tomography Scan: A Pilot Study

Lee

Kim

Cho

et al. 2017

J Korean Soc Radiol

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Multidetector computed tomography (MDCT) of the abdominal solid organs, including the liver and kidney, is an essential imaging modality of routine clinical practice for the diagnosis, treatment planning, and follow-up of many diseases. The diagnostic accuracy of CT examination is highly dependent on the imaging protocols and, in particular, on contrast media (CM) Purpose: Our objective was to compare the effects of different iodine concentrations on characterizing small renal lesions. Materials and Methods: Thirty-eight patients were enrolled in this study. All patients underwent an initial CT scan using 370 mgI/mL iodinated contrast media. Patients were then randomized into two groups for a follow-up CT. Group A (n = 19) received 250 mgI/mL iodinated contrast media, and group B (n = 19) received 300 mgI/mL contrast media. The mean Hounsfield units (HU values) of small renal lesions with a maximum size of less than 2 cm were calculated. Signal to noise ratios (SNR values) were likewise evaluated. Three uroradiologists assessed the lesion's conspicuity and the diagnostic influence of the artifact's proximity to the adjacent renal parenchyma. Results: In group A, there were significant differences between the HU values of renal lesions and those of the adjacent renal parenchyma between the initial and follow-up CT. Conversely, in group B, there was no significant difference. Moreover, SNR values showed no statistically significant difference between both groups. Regarding lesion conspicuity, only one reader identified a significant difference (p = 0.032) in group A; whereas in group B, there was no statistical difference. The artifact's proximity to the adjacent renal parenchyma did not appear to have any diagnostic influence on differentiating the two (p < 0.05). Conclusion:In evaluating small renal lesions, 300 mgI/mL instead of 370 mgI/mL contrast media can be used; however, it is important to note that the use of 250 mgI/ mL contrast media may reveal different results from that of 370 mgI/mL contrast media. Index terms

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of the Effects of Different Iodine Concentrations on the Characterization of Small Renal Lesions Detected by Multidetector Computed Tomography Scan: A Pilot Study

Lee

Kim

Cho

et al. 2017

J Korean Soc Radiol

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“…In intravenous contrast-enhanced CT, the enhancing effect is reported to be determined by the technique 2,[5][6][7]9,11,12,14) of the administration of the contrast medium, including the infusion rate, infusion method, infusion volume, and the time of the beginning of scanning (delay time), and physiologic factors 2,8,10,15) in the patient such as the age, body weight, hemodynamics, and renal function. However, in consideration of differences in the environment, purpose, and area of scanning at various institutions, it would be extremely difficult to comprehensively evaluate these factors and establish a method for the administration of the contrast medium applicable to all institutions.…”

Section: Discussionmentioning

confidence: 99%

“…Contrastenhanced CT is particularly effective for clarification of internal properties and extent of the lesion and the spatial relationships between blood vessels and the lesion. In intravenous contrast-enhanced CT, it is desirable to maintain the concentration of the contrast medium in blood as high and stable as possible from the beginning to the end of scanning, but this is made difficult by the current techniques 2,[5][6][7]9,11,12,14) for the administration of the contrast medium and by consideration of the patient problems 2,8,10,15) . The concentration of the contrast medium is also affected by the types of medium and CT system used.…”

Section: Introductionmentioning

confidence: 99%

Contrast-Enhanced Conventional CT in Patients after Surgery for Malignant Tumors. Evaluation of the Optimal Method of the Administration of the Contrast Medium.

Wakoh

Yamada

Mori

et al. 2000

Bull. Tokyo Dent. Coll.

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Patients after ablative surgery for malignant tumors require computed tomography (CT) examination of a wide area on the head and neck to follow-up for recurrence and lymph metastasis. The aim of this study was to determine a more effective method for the infusion of the contrast medium into post-operative patients undergoing conventional CT, based on the relationship between the method of administering the contrast medium and the contrast-enhancing effect in the internal jugular vein. First eleven images were selected from the existing contrast-enhanced and plain CT images in a manner such that the CT values of the internal jugular vein were distributed evenly in a range of 50-180. Seven experienced observers evaluated the contrast-enhancing effect of each image set at a window value of 40 and window widths of 120, 200, and 280. Secondly, the CT values of the right internal jugular vein were measured in a total of 10 CT images from the thyroid to maxillary sinus level from each of 60 post-operative patients. The injection needles and contrast-enhancing techniques used in the 60 patients were drip infusion using an 18G injection needle in 20, drip infusion using a 21G injection needle with bolus intravenous injection immediately before scanning in 20, and drip infusion using a 23G injection needle with bolus intravenous injection immediately before scanning in 20. A CT value of 100 or above, preferably 120 or above, in the internal jugular vein was needed for the contrast-enhancing effect of a CT image to be judged as clinically significant.Our results found that, when a conventional CT was used in patients after surgery for malignant tumors, drip infusion using a 21G or 23G injection needle should be combined with bolus injections immediately before the beginning of scanning, and at the glottis or submandibular gland level during the scanning. A sufficient contrast-enhancing effect can also be obtained by drip infusion using an 18G injection needle without bolus injection.

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“…These factors may be divided into three categories: patient, contrast medium, and CT scanning [6]. Among patient related factors, the most important one affecting the magnitude of vascular and parenchymal contrast enhancement is body weight [7][8][9][10][11]. This effect can be best described on the basis of the association of the body weight with the blood volume.…”

Section: Introductionmentioning

confidence: 99%

Association of Renal Volume with the Degree of Aortic Contrast Enhancement in Abdominal CT

Muto¹,

Kamishima²,

Sasaki³

et al. 2013

ACT

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To assess the correlation of renal volume measured on CT with aortic contrast enhancement on the hepatic arterial phase of dynamic CT, 64 consecutive patients (34 men, 30 women) were retrospectively examined. Renal volumes were measured on CT. The aortic contrast enhancement was inversely correlated with renal medullary volume (r = −0.52, p < 0.0001), and renal cortical volume (r = −0.3, p = 0.02). Renal volume may have inverse correlation with aortic contrast enhancement on the hepatic arterial phase of dynamic CT. This might call for adjustment of contrast material dose based in part on renal volume in the future.

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Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement.

Cited by 278 publications

References 0 publications

Analysis of the Effects of Different Iodine Concentrations on the Characterization of Small Renal Lesions Detected by Multidetector Computed Tomography Scan: A Pilot Study

Analysis of the Effects of Different Iodine Concentrations on the Characterization of Small Renal Lesions Detected by Multidetector Computed Tomography Scan: A Pilot Study

Contrast-Enhanced Conventional CT in Patients after Surgery for Malignant Tumors. Evaluation of the Optimal Method of the Administration of the Contrast Medium.

Association of Renal Volume with the Degree of Aortic Contrast Enhancement in Abdominal CT

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