Dynamic hook-and-eye nanoparticle sponges

Klajn, Rafał; Olson, Mark A.; Wesson, Paul J.; Fang, Lei; Coskun, Ali; Trabolsi, Ali; Soh, Siowling; Stoddart, J. Fraser; Grzybowski, Bartosz A.

doi:10.1038/nchem.432

Cited by 118 publications

(159 citation statements)

References 50 publications

Supporting

Mentioning

147

Contrasting

Order By: Relevance

“…7–9 The same optical properties also make them promising contrast agents for biomedical imaging. 10–12 Versatility of chemical modification of gold surface makes possible the use of Au NPs for difficult tasks of deep tissue imaging, 13 drug delivery with release-on-command capabilities, 14 chemical 15 and photothermal therapy 16–18 of cancer.…”

Section: Introductionmentioning

confidence: 99%

Regiospecific Plasmonic Assemblies for in Situ Raman Spectroscopy in Live Cells

et al. 2012

View full text Add to dashboard Cite

Multiple properties of plasmonic assemblies are determined by their geometrical organization. While high degree of complexity was achieved for plasmonic superstructures based on nanoparticles (NPs) little is known about the stable and structurally reproducible plasmonic assemblies made up from geometrically diverse plasmonic building blocks. Among other possibilities they open the door for the preparation of regiospecific isomers of nanoscale assemblies significant both from fundamental point of view and optical applications. Here we present a synthetic method for complex assemblies from NPs and nanorods (NRs) based on selective modification of NRs with DNA oligomers. Three types of assemblies denoted as End, Side, and Satellite isomers which display distinct elements of regiospecificity, were prepared with the yield exceeding 85%. Multiple experimental methods independently verify various structural features, uniformity, and stability of the prepared assemblies. The presence of interparticle gaps with finely controlled geometrical parameters and inherently small size comparable with those of cellular organelles fomented their study as intracellular probes. Against initial expectations SERS intensity for End, Side, and Satellite isomers was found to be dependent primarily on the number of the NPs in the superstructures rationalized with the help of electrical field simulations. Incubation of the label-free NP-NR assemblies with HeLa cells indicated sufficient field enhancement to detect structural lipids of mitochondria and potentially small metabolites. This provided the first proof-of-concept data for the possibility of real-time probing of local organelle environment in live cells. Further studies should include structural optimization of the assemblies for multitarget monitoring of metabolic activity and further increase in complexity for applications in transformative optics.

show abstract

Section: Introductionmentioning

confidence: 99%

Regiospecific Plasmonic Assemblies for in Situ Raman Spectroscopy in Live Cells

et al. 2012

View full text Add to dashboard Cite

show abstract

“…hydrogen bonding, ion-ion, pi-pi stacking and van der Waals interactions), supramolecular complexes are inherently dynamic in nature and highly selective toward other complementary guest molecules through these various weak and reversible interactions 7. As a result of the modularity and the reversibility, supramolecular systems can be engineered to assemble and disassemble spontaneously in response to a range of triggers 2, 1, 8…”

mentioning

confidence: 99%

Recognition-mediated activation of therapeutic gold nanoparticles inside living cells

et al. 2010

View full text Add to dashboard Cite

Supramolecular chemistry provides a versatile tool for the organization of molecular systems into functional structures and the actuation of these assemblies for applications through the reversible association between complementary components. Application of this methodology in living systems represents a significant challenge due to the chemical complexity of cellular environments and lack of selectivity of conventional supramolecular interactions. Herein, we present a host-guest system featuring diaminohexane-terminated gold nanoparticles (AuNP-NH2) and complementary cucurbit[7]uril (CB[7]). In this system, threading of CB[7] on the particle surface reduces the cytotoxicity of AuNP-NH2 through sequestration of the particle in endosomes. Intracellular triggering of the therapeutic effect of AuNP-NH2 was then achieved via the administration of 1-adamantylamine (ADA), removing CB[7] from the nanoparticle surface and triggering the endosomal release and concomitant in situ cytotoxicity of AuNP-NH2. This supramolecular strategy for intracellular activation provides a new tool for potential therapeutic applications.

show abstract

“…As an alternative to photoresponsive systems, redox-responsive host-guest complexes represent another route for constructing supramolecular electromechanical devices [26][27][28] . Both ferrocene 29 and viologen derivatives 30,31 have been used as guests for supramolecular macrocyclic hosts [32][33][34][35][36][37] .…”

mentioning

confidence: 99%

Orthogonal switching of a single supramolecular complex

et al. 2012

View full text Add to dashboard Cite

Orthogonal control over systems represents an advantage over mono-functional switches as both the nature and order of distinctly different stimuli manifest themselves in a wide array of outcomes. Host-guest complexes with multiple, simultaneously bound guests offer unique opportunities to address a set of 'on' and 'off' states accessible on demand. Here we report cucurbit[8]uril-mediated host-guest heteroternary complexes constructed with both redoxand light-responsive guests in a single, supramolecular entity. The complex responds to orthogonal stimuli in a controlled, reversible manner generating a multifunctional switch between a 'closed' heteroternary complex, a redox-driven 'closed' homoternary complex and a photo-driven 'open' uncomplexed state. We exploit both photochemical and electrochemical control over the supramolecular coding system and its surface wettability to demonstrate the system's complexity, which could be readily visualized on a macroscopic level, thus offering new opportunities in the construction of memory devices.

show abstract

Dynamic hook-and-eye nanoparticle sponges

Cited by 118 publications

References 50 publications

Regiospecific Plasmonic Assemblies for in Situ Raman Spectroscopy in Live Cells

Regiospecific Plasmonic Assemblies for in Situ Raman Spectroscopy in Live Cells

Recognition-mediated activation of therapeutic gold nanoparticles inside living cells

Orthogonal switching of a single supramolecular complex

Contact Info

Product

Resources

About