Dynamic Foraging Behavior Performance Is Not Affected byScn2aHaploinsufficiency
Selin Schamiloglu,
Hao Wu,
Mingkang Zhou
et al.
Abstract:Dysfunction in the geneSCN2A, which encodes the voltage-gated sodium channel Nav1.2, is strongly associated with neurodevelopmental disorders including autism spectrum disorder and intellectual disability (ASD/ID). This dysfunction typically manifests in these disorders as a haploinsufficiency, where loss of one copy of a gene cannot be compensated for by the other allele.Scn2ahaploinsufficiency affects a range of cells and circuits across the brain, including associative neocortical circuits that are importan… Show more
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