Dynamic fibroblast-immune interactions shape wound healing after brain injury
Nathan A. Ewing-Crystal,
Nicholas M. Mroz,
Anthony A. Chang
et al.
Abstract:Fibroblasts coordinate the response to tissue injury, directing organ regeneration versus scarring. In the central nervous system (CNS), fibroblasts are uncommon cells enriched at tissue borders, and their molecular, cellular, and functional interactions after brain injury are poorly understood. Here we define the fibroblast response to sterile brain damage across time and space. Early pro-fibrotic myofibroblasts infiltrated CNS lesions and were functionally and spatially organized by fibroblast TGFβsignaling,… Show more
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