Dynamic eye phantom for retinal oximetry measurements

Lemaillet, Paul; Ramella‐Roman, Jessica C.

doi:10.1117/1.3258669

Cited by 12 publications

(11 citation statements)

References 27 publications

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“…The construction of these scattering and absorbing structures is described elsewhere [22] and we direct the reader to that article for an in-depth review of the methodology.…”

Section: Methodsmentioning

confidence: 99%

Microfluidics based phantoms of superficial vascular network

Luu¹,

Roman²,

Mathews³

et al. 2012

Biomed. Opt. Express

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Several new bio-photonic techniques aim to measure flow in the human vasculature non-destructively. Some of these tools, such as laser speckle imaging or Doppler optical coherence tomography, are now reaching the clinical stage. Therefore appropriate calibration and validation techniques dedicated to these particular measurements are therefore of paramount importance. In this paper we introduce a fast prototyping technique based on laser micromachining for the fabrication of dynamic flow phantoms. Micro-channels smaller than 20 µm in width can be formed in a variety of materials such as epoxies, plastics, and household tape. Vasculature geometries can be easily and quickly modified to accommodate a particular experimental scenario.

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“…The construction of these scattering and absorbing structures is described elsewhere [22] and we direct the reader to that article for an in-depth review of the methodology.…”

Section: Methodsmentioning

confidence: 99%

Microfluidics based phantoms of superficial vascular network

Luu¹,

Roman²,

Mathews³

et al. 2012

Biomed. Opt. Express

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“…Various strategies to phantom design and construction have been implemented. Lemaillet et al, (2009) [81] developed a multi-layered dynamic eye phantom, incorporating flowing blood to simulate in vivo blood flow. Flowing blood is known to have different reflectance and scattering parameters than static blood due to alignment of red blood cells in laminar flow conditions.…”

Section: Eye-mimicking Ex Vivo Oximetry Phantomsmentioning

confidence: 99%

Spectroscopic oximetry in the eye: a review

Mackenzie

Harvey

McNaught

2017

Expert Review of Ophthalmology

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Introduction: Non-invasive measurement of blood oxygen saturation via spectroscopic imaging has facilitated insights into the development and progression of a variety of ocular conditions, including retinal vascular occlusion, diabetic retinopathy and glaucoma. Major developments since the late 90s have been enabled by advancements in imaging technology, computational image analysis, and experimental methods. Areas covered: We review the theory of spectroscopic oximetry, the ocular blood vessels targeted for oximetry, imaging systems used for oximetry, and oximetry validation methods. Important physiological and clinical insights provided by oximetry in the eye are detailed. Expert commentary: Oximetry has revealed physiological norms and auto-regulatory effects in the retina, choroid, episcleral, and bulbar conjunctival blood vessels. Retinal oximetry has provided crucial insight into the development of diabetic retinopathy and glaucoma, and has enhanced the evaluation and treatment of retinal vessel occlusion. Commercially available retinal oximetry systems have enabled oximetry in the clinic. The development more sophisticated phantoms that resemble in vivo environments has oximetry validation in diverse oximetry applications. New insights into ocular physiology and disease are likely to be gleaned from future studies.

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“…The vessel, a Teflon ® tube of inner diameter 165 m ͑object plane pixel size 7.86 m͒, was positioned inside an eye phantom that mimics the optics of the human eye. 13 The capillary tube was connected to a syringe pump ͑Hamilton, Reno, Nevada͒, and the pump rate could be adjusted to different values. For this study, flow rates of 50 l / h to several hundreds were used.…”

Section: Data Acquisitionmentioning

confidence: 99%

Absolute blood velocity measured with a modified fundus camera

et al. 2010

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We present a new method for the quantitative estimation of blood flow velocity, based on the use of the Radon transform. The specific application is for measurement of blood flow velocity in the retina. Our modified fundus camera uses illumination from a green LED and captures imagery with a high-speed CCD camera. The basic theory is presented, and typical results are shown for an in vitro flow model using blood in a capillary tube. Subsequently, representative results are shown for representative fundus imagery. This approach provides absolute velocity and flow direction along the vessel centerline or any lateral displacement therefrom. We also provide an error analysis allowing estimation of confidence intervals for the estimated velocity.

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Dynamic eye phantom for retinal oximetry measurements

Cited by 12 publications

References 27 publications

Microfluidics based phantoms of superficial vascular network

Microfluidics based phantoms of superficial vascular network

Spectroscopic oximetry in the eye: a review

Absolute blood velocity measured with a modified fundus camera

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