Dynamic expression of R-spondin family genes in mouse development

Nam, Ju-Suk; Turcotte, Taryn J.; Yoon, Jong‐Hwan

doi:10.1016/j.modgep.2006.08.006

Cited by 120 publications

(157 citation statements)

References 14 publications

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“…In Xenopus and mouse, Rspo family members show differential expression in a broad range of embryonic tissues, such as dorsal neural tube, somites, tailbud, AER of the limb, and developing brain (Kazanskaya et al 2004;Nam et al 2007b). They are coexpressed with several Wnt genes and their expression is regulated by Wnts (Kazanskaya et al 2004).…”

Section: Role Of Rspos In Embryonic Development and Diseasementioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

514

440

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Section: Role Of Rspos In Embryonic Development and Diseasementioning

confidence: 99%

Secreted and Transmembrane Wnt Inhibitors and Activators

Cruciat

Niehrs

2012

Cold Spring Harbor Perspectives in Biology

514

440

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“…In situ hybridization analysis has shown the expression of the canonical ligands R-spondin1 and Rspondin3 in the peripheral metanephric mesenchyme or stroma [109]. What role are these factors playing in kidney development and how does it relate to the function of the traditional ligands?…”

Section: Summary and Future Of The Fieldmentioning

confidence: 99%

Molecular regulation of kidney development: is the answer blowing in the Wnt?

2007

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Development of the metanephric kidney is a complicated process regulated by reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate tubule formation and epithelial branching morphogenesis. Over the past several years, several studies have suggested that Wnt signaling is involved in multiple aspects of normal kidney development as well as injury response and cancer progression. We will review these data here.

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“…The R-spondin (RSPO) protein family consists of four homologous members, which are evolutionarily conserved in vertebrates and are involved in a broad range of developmental and physiological processes (5,6): RSPO1 is important for sex determination (7); RSPO2 is required for limb, laryngeal-tracheal and lung development (8); RSPO3 is critical for placental formation (9); and the mutation of RSPO4 results in inherited anonychia (10). The association between RSPO and cancer has not been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

R-spondin 2 promotes proliferation and migration via the Wnt/β-catenin pathway in human hepatocellular carcinoma

Yin

Wang

et al. 2017

Oncology Letters

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Abstract. Hepatocellular carcinoma (HCC) is a leading cause of malignant disease-associated mortality, particularly in China. The RSPO2 (R-spondin 2) gene is evolutionarily conserved in vertebrates and is involved in developmental and physiological processes. Importantly, RSPO2 has been reported to be associated with colon cancer and potentiate the Wnt/β-catenin signaling pathway. In the present study, enhanced expression of RSPO2 in HCC was observed using tissue microarray. Similarly, the expression level of RSPO2 was higher in HepG2, Huh7 and Hep3B cells but lower in Bel7404 and QGY7703 cells compared with human normal QSG7701 liver cells. Subsequently, gain-of-function studies indicated that RSPO2 promotes the proliferation and migration of QGY7703 cells based on lentivirus-based gene delivery. Furthermore, it was revealed that p21 and leptin, rather than vascular endothelial growth factor-A, are involved in the function of RSPO2 in QGY7703 cells. Particularly, the signal transducer and activator of transcription 3 (STAT3) and Wnt/β-catenin signaling pathways are involved in this process. Overexpression of RSPO2 resulted in the elevated expression of phosphorylated STAT3, β-catenin and c-Myc. Therefore, the present study is beneficial to the understanding of RSPO2-involved liver cancer transformation and drug discovery.

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Dynamic expression of R-spondin family genes in mouse development

Cited by 120 publications

References 14 publications

Secreted and Transmembrane Wnt Inhibitors and Activators

Secreted and Transmembrane Wnt Inhibitors and Activators

Molecular regulation of kidney development: is the answer blowing in the Wnt?

R-spondin 2 promotes proliferation and migration via the Wnt/β-catenin pathway in human hepatocellular carcinoma

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