Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue

Rex, Maria; Orme, Alex; Uwanogho, Dafe; Tointon, Kevin; Wigmore, Peter; Sharpe, Paul T.; Scotting, Paul J.

doi:10.1002/(sici)1097-0177(199707)209:3<323::aid-aja7>3.3.co;2-b

Cited by 64 publications

(88 citation statements)

References 30 publications

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“…As in other vertebrates (Penzel et al, 1997;Rex et al, 1997), zebrafish sox3 is highly expressed in the neural plate from the gastrula stage (Okuda et al, 2006). In addition, we detected sox3 expression in a pair of ectodermal domains lateral to the anterior hindbrain region as early as at the onesomite stage (Figs.…”

Section: Early Development Of the Epibranchial Placode In Zebrafishsupporting

confidence: 83%

Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal

Nikaido

Doi

Shimizu³

et al. 2006

Developmental Dynamics

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In vertebrates, cranial sensory ganglia are mainly derived from ectodermal placodes, which are focal thickenings at characteristic positions in the embryonic head. Here, we provide the first description of the early development of the epibranchial placode in zebrafish embryos using sox3 as a molecular marker. By the one-somite stage, we saw a pair of single sox3-expressing domains appear lateral to the future hindbrain. The sox3 domain, which is referred to here as the early lateral placode, is segregated during the early phase of segmentation to form a pax2a-positive medial area and a pax2a-negative lateral area. The medial area subsequently developed to form the otic placode, while the lateral area was further segregated along the anteroposterior axis, giving rise to four sox3-positive subdomains by 26 hr postfertilization. Given their spatial relationship with the expression of the markers for the epibranchial ganglion, as well as their positions and temporal changes, we propose that these four domains correspond to the facial, glossopharyngeal, vagal, and posterior lateral line placodes in an anterior-to-posterior order. The expression of sox3 in the early lateral placode was absent in mutants lacking functional fgf8, while implantation of fibroblast growth factor (FGF) beads restored the sox3 expression. Using SU5402, which inhibits the FGF signal, we were able to demonstrate that formation of both the early lateral domains and later epibranchial placodes depends on the FGF signal operating at the beginning of somitogenesis. Together, these data provide evidence for the essential role of FGF signals in the development of the epibranchial placodes. Developmental Dynamics 236:564 -571, 2007.

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Section: Early Development Of the Epibranchial Placode In Zebrafishsupporting

confidence: 83%

Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal

Nikaido

Doi

Shimizu³

et al. 2006

Developmental Dynamics

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“…(i) SoxB proteins and Gsh-1/2 are expressed in the right time and place to regulate ac/sc gene expression in vertebrates. For example, SoxB-type genes are expressed widely in the early CNS (24,(26)(27)(28)(29) and Gsh-1/2 are expressed in the intermediate domain of the neural tube (24,30,31); (ii) expression of these factors precedes ac/sc expression (24, 32); (iii) Gsh-1/2 repress the expression of the proneural bHLH genes Neurogenin-1 and Neurogenin-2 to regulate cell fate in the vertebrate spinal cord (24,32); (iv) mutations in Sox1 and Gsh-1 function yield similar phenotypes in the ventral telencephalon, suggesting that Sox1, and other SoxB factors, may partner with Gsh-1/2 to regulate neuronal identity (24,33); (v), SoxB factors regulate directly the expression of genes that act with ac/sc proneural genes to regulate neural precursor formation. For example, Sox1 can bind directly to the HES1 promoter and suppress its transcription (24,32).…”

Section: Do Vertebrate Homologs Of Dichaete and Ind Directly Regulatementioning

confidence: 99%

Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS

Zhao

Boekhoff-Falk

Wilson

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Mechanisms regulating CNS pattern formation and neural precursor formation are remarkably conserved between Drosophila and vertebrates. However, to date, few direct connections have been made between genes that pattern the early CNS and those that trigger neural precursor formation. Here, we use Drosophila to link directly the function of two evolutionarily conserved regulators of CNS pattern along the dorsoventral axis, the homeodomain protein Ind and the Sox-domain protein Dichaete, to the spatial regulation of the proneural gene achaete ( ac ) in the embryonic CNS. We identify a minimal achaete regulatory region that recapitulates half of the wild-type ac expression pattern in the CNS and find multiple putative Dichaete-, Ind-, and Vnd-binding sites within this region. Consensus Dichaete sites are often found adjacent to those for Vnd and Ind, suggesting that Dichaete associates with Ind or Vnd on target promoters. Consistent with this finding, we observe that Dichaete can physically interact with Ind and Vnd. Finally, we demonstrate the in vivo requirement of adjacent Dichaete and Ind sites in the repression of ac gene expression in the CNS. Our data identify a direct link between the molecules that pattern the CNS and those that specify distinct cell-types.

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“…It is possible that cells in the rostral neural plate border are specified as rostral placodal progenitor cells, and retain the capacity to adopt either lens or olfactory placodal fate until exposed to additional molecular signals from the surrounding environment. At neural fold stages, Pax6, Dlx5, Six1 and Sox2, are expressed in both lens and olfactory placodal precursor cells [10,19,28]. In addition, at this stage no molecular marker has been shown to distinguish the morphologically separated lens and olfactory placodal precursors, supporting the idea that rostral placodal precursors may initially comprise a common fate.…”

Section: Directed or Random Migrationmentioning

confidence: 86%

The lens: a classical model of embryonic induction providing new insights into cell determination in early development

Gunhaga

2011

Phil. Trans. R. Soc. B

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The lens was the first tissue in which the concept of embryonic induction was demonstrated. For many years lens induction was thought to occur at the time the optic vesicle and lens placode came in contact. Since then, studies have revealed that lens placodal progenitor cells are specified already at gastrula stages, much earlier than previously believed, and independent of optic vesicle interactions. In this review, I will focus on how individual signalling molecules, in particular BMP, FGF, Wnt and Shh, regulate the initial specification of lens placodal cells and the progressive development of lens cells. I will discuss recent work that has shed light on the combination of signalling molecules and the molecular interactions that affect lens specification and proper lens formation. I will also discuss proposed tissue interactions important for lens development. A greater knowledge of the molecular interactions during lens induction is likely to have practical benefits in understanding the causes and consequences of lens diseases. Moreover, knowledge regarding lens induction is providing fundamental important insights into inductive processes in development in general.

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Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue

Cited by 64 publications

References 30 publications

Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal

Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal

Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS

The lens: a classical model of embryonic induction providing new insights into cell determination in early development

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