Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA

Zhou, Jinfeng; Zhang, Liyun; Gu, Yong; Li, Kai; Nie, Yongzhan; Fan, Daiming; Feng, Yue

doi:10.1186/1477-7819-9-172

Cited by 17 publications

(7 citation statements)

References 25 publications

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“…Furthermore, our observation is in agreement with different studies, which showed that the expression of other subfamily members is often associated with tumor grade. In particular, in gastric cancer, CEACAM7 protein expression is more frequently found in poorly differentiated compared to well and moderately differentiated gastric carcinomas (32). Additionally, CEA and CEACAM6 expression in colorectal cancer correlates inversely with the degree of cellular differentiation (33).…”

Section: Discussionmentioning

confidence: 99%

The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression

Michaelidou

Tzovaras

Missitzis

et al. 2013

International Journal of Oncology

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Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other potential molecular markers. CEACAM19, a recently identified gene belonging to CEACAM subfamily, was discovered and cloned by members of our research group. The present study analyzes, quantitatively, the expression of CEACAM19 and evaluates its clinical relevance in BC. Total RNA was extracted from 143 cancerous and 89 normal adjacent breast tissue specimens. Following reverse transcription, quantitative analysis of CEACAM19 mRNA expression levels was performed via real-time PCR and the comparative Ct (2-∆∆Ct) method. CEACAM19 expression and detailed clinicopathological data were used for extensive biostatistical analyses. CEACAM19 was found to be overexpressed in breast cancer tissue specimens compared to normal tissue counterparts (p=0.013). CEACAM19 mRNA expression status was also associated with clinicopathological features indicative of aggressive behavior and poor prognosis in BC, such as high tumor grade (p=0.031) and high Ki67 proliferative index (p=0.038). A significant negative association was documented between CEACAM19 expression and tumor ER status (p=0.018) as well as patients' menopausal state (p=0.016). Our results suggest that CEACAM19 mRNA expression represents a promising, novel and clinically useful tissue biomarker for breast cancer management.

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Section: Discussionmentioning

confidence: 99%

The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression

Michaelidou

Tzovaras

Missitzis

et al. 2013

International Journal of Oncology

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“…Immunohistochemistry (IHC) staining was performed as previously described [ 10 , 11 ]. The primary mouse monoclonal anti-CIAPIN1 antibody (dilution 1:800) was developed in our laboratory [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer

2012

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BackgroundEpithelial ovarian cancer (EOC) is an aggressive disease with poor prognosis. The expression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) correlates with the malignant progression of several cancers. However, the relationship between the subcellular localization of CIAPIN1 and clinical characteristics in EOC remains unclear.MethodsImmunohistochemistry was performed to detect CIAPIN1 expression in 108 EOC tissues. CIAPIN1 expressions in eight fresh EOC tissues were detected by Western blotting. The relationship between CIAPIN1 subcellular expression and patients’ clinicopathological features, including prognosis, was evaluated. Immunohistochemistry and immunofluorescence were employed to assess the CIAPIN1 subcellular localization in the EOC cell lines A2780 and HO8910. In addition, all patients were followed up to assess the prognostic value of CIAPIN1 in patients with EOC.ResultsCIAPIN1 is highly expressed in EOC, but is present at low levels in paired non-cancerous ovarian epithelial tissues. The results of Western blotting were in accordance with the immunohistochemical results. Poor differentiation of the tumors and EOC cell lines correlated with higher levels of CIAPIN1 nuclear expression. CIAPIN1 nuclear expression significantly correlated with the Federation International of Gynecology and Obstetrics (FIGO) stage and histological differentiation (P = 0.034 and P < 0.0001, respectively). Moreover, nuclear localization of CIAPIN1 was selected as an unfavorable prognostic factor by both univariate and multivariate analyses ( P < 0.001). However, no significant correlations were observed between cytoplasmic localization of CIAPIN1 and clinicopathological parameters.ConclusionsCIAPIN1 might play a crucial role in the differentiation of EOC cells. Elevated expression of nuclear CIAPIN1 negatively correlated with the survival of EOC patients, suggesting that nuclear CIAPIN1 might serve as a prognostic biomarker for EOC patients.

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“…One hypothesis is that the quantitative expression of CEA would be different according to epithelial subtypes. Although CEA is most well known to be expressed in colorectal cancer tissues that share the immunophenotype with intestinal-type IPMNs [28], it is also reported to be expressed in gastric cancer and precursor lesions of gastric cancer [29], and pancreatic ductal adenocarcinoma [30]. Thus, each epithelial subtype of IPMN might have the potential to express CEA.…”

Section: Pancreatobiliarymentioning

confidence: 99%

Characterization of epithelial subtypes of intraductal papillary mucinous neoplasm of the pancreas with endoscopic ultrasound and cyst fluid analysis

et al. 2014

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Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA

Cited by 17 publications

References 25 publications

The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression

The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression

CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer

Characterization of epithelial subtypes of intraductal papillary mucinous neoplasm of the pancreas with endoscopic ultrasound and cyst fluid analysis

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