Dynamic electrocardiography with strenuous exertion at high altitudes

Politte, Lenard L.; Almond, Carl H.; Logue, John T.

doi:10.1016/0002-8703(68)90019-7

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…Even if under rest conditions at very high altitude few arrhythmias have been documented in healthy young subjects, 6–8 some authors have observed frequent ectopic beats or more complex arrhythmias in such a population during or immediately after exercise, both in mountains hypoxia and under conditions of simulated altitude 8–11 …”

Section: Discussionmentioning

confidence: 99%

“…Abbreviations: IPAB = isolated premature atrial beat; IPVB = isolated premature ventricular beat; RAA = repetitive atrial arrhythmias (couplets and triplets); VC = ventricular couplets; VT = ventricular triplets; AT = atrial tachycardia; RVA = repetitive ventricular arrhythmias rhythmias in such a population during or immediately after exercise, both in mountains hypoxia and under conditions of simulated altitude. [8][9][10][11] Actually, several investigators demonstrated an increased beta-adrenergic activity in normal subjects during exercise both in normoxia and under altitude hypoxia. [12][13][14] Furthermore, it has been shown that hypoxia strongly potentiates the exercise-induced sympathetic activity by a synergist interaction.…”

Section: Rest Altitudementioning

confidence: 99%

“…Although altitude‐induced arrhythmias have not been observed at rest in healthy subjects, 6–8 atrial and ventricular premature beats and more complex arrhythmias have been detected during or soon after exercise in healthy people 8–11 . Indeed, several findings indicate an enhanced beta‐adrenergic activation during exercise both in conditions of normoxia and under hypoxia 12–14 …”

Section: Introductionmentioning

confidence: 99%

“…5 Although altitude-induced arrhythmias have not been observed at rest in healthy subjects, [6][7][8] atrial and ventricular premature beats and more complex arrhythmias have been detected during or soon after exercise in healthy people. [8][9][10][11] Indeed, several findings indicate an enhanced betaadrenergic activation during exercise both in conditions of normoxia and under hypoxia. [12][13][14] Minor rhythm disturbances are not thought to be clinically important in healthy subjects 8 ; however, the susceptibility of healthy myocardium to more dangerous ventricular arrhythmias during exercise at high altitude remains still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Arrhythmic Risk Evaluation during Exercise at High Altitude in Healthy Subjects: Role of Microvolt T‐Wave Alternans

Gibelli

Fantoni

Anzà

et al. 2008

Pacing Clinical Electrophis

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Section: Discussionmentioning

confidence: 99%

Section: Rest Altitudementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Arrhythmic Risk Evaluation during Exercise at High Altitude in Healthy Subjects: Role of Microvolt T‐Wave Alternans

Gibelli

Fantoni

Anzà

et al. 2008

Pacing Clinical Electrophis

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“…Unfortunately, the effect of the sympathetic stimulus seen at altitude has not been formally assessed in those with LQTS. However, the majority of studies that have looked at the effect of altitude upon healthy individuals have shown that QTc does increase and is sustained throughout an individual's stay at altitude [30][31][32][33][34][35][36][37].…”

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

Prolongation of the Corrected QT Complex – A Cause of Sudden Cardiac Death in the Mountain Environment?

et al. 2011

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In the mountain environment sudden cardiac death (SCD) has been shown to be responsible for the deaths of up to 52% of downhill skiers and 30% of hikers. The majority of SCD's are precipitated by a ventricular arrhythmia. Although most are likely to result from structural abnormalities associated with conditions such as ischaemic heart disease, a small but significant number may be due to abnormalities in ion channel activity, commonly known as, "channelopathies". Channelopathies have the potential to lengthen the time between ventricular depolarisation and repolarisation that can result in prolongation of the corrected QT interval (QTc) and episodes of polymorphic ventricular tachycardia (PVT) and eventually, ventricular fibrillation. This review examines the factors that prolong the QTc interval in the mountain environment and outlines a practical framework for preventing the life threatening arrhythmias that are associated with this condition.

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Changes of heart rate and QT interval at high altitude in alpinists: Analysis by holter ambulatory electrocardiogram

Horii

Takasaki

Ohtsuka

et al. 1987

Clinical Cardiology

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Summary:The purpose of this study is to record continuously electrocardiograms of alpinists during different activities practiced in mountaineering, compare heart rate and QT interval at high altitude with those at sea level, and compare alpinists with nonalpinists. Analysis was attempted on 14 alpinists (9 male, 5 female, ages 26-45) to determine changes in heart rate and QT interval using continuous ambulatory electrocardiograms recorded at sea level and high altitude. Between 1983 and 1984,9 of 14 alpinists (6 male, 3 female) were subjected to the study at high altitude, that is, at Mt. Kangchenjunga (Himalaya), Mt. Satopanth (Himalaya), and Mt. Jitudake (Butan), 4400 to 7800 m (mean 5710 m). The following were noted: (1) Heart rate at high altitude was significantly higher both in daytime and nighttime. The circadian rhythm of the heart rate disappeared at extremely high altitude in several alpinists. (2) A high correlation was noted between measured QT interval (QTm) and RR interval (r=0.81, p=0.005). Nighttime QT, at high altitude was prolonged in comparison with that of daytime so far as the RR interval remained the same. (3) At high altitude, the nighttime corrected QT interval (QT,) was also significantly prolonged in spite of shortened RR interval. The mechanism of QTc prolongation is not clear. Many factors may impact on the QT interval during mountaineering.

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Dynamic electrocardiography with strenuous exertion at high altitudes

Cited by 4 publications

References 11 publications

Arrhythmic Risk Evaluation during Exercise at High Altitude in Healthy Subjects: Role of Microvolt T‐Wave Alternans

Arrhythmic Risk Evaluation during Exercise at High Altitude in Healthy Subjects: Role of Microvolt T‐Wave Alternans

Prolongation of the Corrected QT Complex – A Cause of Sudden Cardiac Death in the Mountain Environment?

Changes of heart rate and QT interval at high altitude in alpinists: Analysis by holter ambulatory electrocardiogram

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